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    SYG1 Syg1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854764, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SYG1
    Official Full Name
    Syg1p
    Primary source
    SGD:S000001309
    Locus tag
    YIL047C
    See related
    AllianceGenome:SGD:S000001309; FungiDB:YIL047C; VEuPathDB:YIL047C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable inositol hexakisphosphate binding activity and phosphate ion transmembrane transporter activity. Involved in signal transduction. Located in plasma membrane. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human XPR1 (xenotropic and polytropic retrovirus receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SYG1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (265115..267823, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene putative polyprenol reductase Neighboring gene putative aminophospholipid-translocating P4-type ATPase NEO1 Neighboring gene uncharacterized protein Neighboring gene ubiquitin-binding SDF ubiquitin ligase complex subunit MET30

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Truncated forms of a novel yeast protein suppress the lethality of a G protein alpha subunit deficiency by interacting with the beta subunit. Spain BH, et al. J Biol Chem, 1995 Oct 27. PMID 7592711
    2. The role of the Parkinson's disease gene PARK9 in essential cellular pathways and the manganese homeostasis network in yeast. Chesi A, et al. PLoS One, 2012. PMID 22457822, Free PMC Article
    3. Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis. Huber A, et al. Genes Dev, 2009 Aug 15. PMID 19684113, Free PMC Article
    4. Secretory pathway genes assessed by high-throughput microscopy and synthetic genetic array analysis. Bircham PW, et al. Mol Biosyst, 2011 Sep. PMID 21731954
    5. Transfer of the Septin Ring to Cytokinetic Remnants in ER Stress Directs Age-Sensitive Cell-Cycle Re-entry. Chao JT, et al. Dev Cell, 2019 Oct 21. PMID 31564614, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables inositol hexakisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to phosphate starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Syg1p
    NP_012217.3
    • Plasma membrane hypothetical protein; targeted to vacuole via AP-3 pathway; truncation and overexpression suppresses lethality of G-alpha protein deficiency

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      265115..267823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179397.3 → NP_012217.3  TPA: Syg1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012217.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVN4, P40528, P40964
      UniProtKB/TrEMBL
      A6ZVM2
      Conserved Domains (2) summary
      COG5408
      Location:1 → 310
      COG5408; SPX domain-containing protein [Signal transduction mechanisms]
      COG5409
      Location:402 → 803
      COG5409; EXS domain-containing protein [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40528.1

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