YOR1 ATP-binding cassette transporter YOR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: YOR1
Official Full Name: ATP-binding cassette transporter YOR1
Primary source: SGD:S000003513
Locus tag: YGR281W
See related: AllianceGenome:SGD:S000003513; FungiDB:YGR281W; VEuPathDB:YGR281W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: YRS1
Summary: Enables ABC-type xenobiotic transporter activity. Involved in xenobiotic transport. Located in plasma membrane. Used to study cystic fibrosis. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; allergic bronchopulmonary aspergillosis; bronchial disease (multiple); congenital bilateral absence of vas deferens (multiple); and lung disease (multiple). Orthologous to several human genes including CFTR (CF transmembrane conductance regulator). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YOR1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (1052824..1057257)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data reveal that it is possible to modulate activity of ABC transporters Yor1p by physically replacing dysfunctional domains.
Title: Functional rescue of a misfolded eukaryotic ATP-binding cassette transporter by domain replacement.
Mapping of interdomain interfaces required for the functional architecture of Yor1p, a eukaryotic ATP-binding cassette (ABC) transporter
Title: Mapping of interdomain interfaces required for the functional architecture of Yor1p, a eukaryotic ATP-binding cassette (ABC) transporter.
Yor1p also confers resistance to rhodamine 6G and to doxorubicin.
Title: Functional characterization of the Saccharomyces cerevisiae ABC-transporter Yor1p overexpressed in plasma membranes.
Endoplasmic reticulum quality control checkpoint engages misfolded Yor1p even after it has been stabilized by inhibition of the degradative pathway.
Title: Inhibiting endoplasmic reticulum (ER)-associated degradation of misfolded Yor1p does not permit ER export despite the presence of a diacidic sorting signal.
Strains expressing Yor1p display an energy-dependent efflux of cadmium estimated for the yeasts overexpressing Yor1p to be about 0.02 nmol 109Cd/mg protein/min.
Title: Role of the yeast ABC transporter Yor1p in cadmium detoxification.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ABC-type cadmium transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type glutathione S-conjugate transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ABC-type xenobiotic transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ABC-type xenobiotic transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cadmium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transport	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP-binding cassette transporter YOR1

NP_011797.3

EC 7.2.2.2

EC 7.6.2.3

Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter mediates export of many different organic anions including oligomycin; homolog of human cystic fibrosis transmembrane receptor (CFTR)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

1052824..1057257

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181410.3 → NP_011797.3 TPA: ATP-binding cassette transporter YOR1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011797.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VV58, P53049

UniProtKB/TrEMBL

A6ZUT7, B3LHW4, C7GNF4, C8Z9H4, N1P9Z8

Conserved Domains (1) summary

TIGR00957
Location:92 → 1468

MRP_assoc_pro; multi drug resistance-associated protein (MRP)