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    DLD3 D-lactate dehydrogenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856638, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DLD3
    Official Full Name
    D-lactate dehydrogenase
    Primary source
    SGD:S000000797
    Locus tag
    YEL071W
    See related
    AllianceGenome:SGD:S000000797; FungiDB:YEL071W; VEuPathDB:YEL071W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables (D)-2-hydroxyglutarate-pyruvate transhydrogenase activity; D-lactate dehydrogenase (cytochrome) activity; and FAD binding activity. Involved in filamentous growth and lactate biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 1. Orthologous to human D2HGDH (D-2-hydroxyglutarate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See DLD3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (16355..17845)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rmd6p Neighboring gene mannitol dehydrogenase DSF1 Neighboring gene hexose transporter HXT13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mks1p is required for negative regulation of retrograde gene expression in Saccharomyces cerevisiae but does not affect nitrogen catabolite repression-sensitive gene expression. Tate JJ, et al. J Biol Chem, 2002 Jun 7. PMID 11923302, Free PMC Article
    2. A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase. Hauser M, et al. FEMS Yeast Res, 2007 Jan. PMID 16999827
    3. Kinetic properties of yeast D(-)-lactic cytochrome c reductase. NYGAARD AP. J Biol Chem, 1961 Jul. PMID 13729967
    4. Signalling between mitochondria and the nucleus regulates the expression of a new D-lactate dehydrogenase activity in yeast. Chelstowska A, et al. Yeast, 1999 Sep 30. PMID 10509019
    5. Quantitative Proteomics Combined with Two Genetic Strategies for Screening Substrates of Ubiquitin Ligase Hrt3. Lan Q, et al. J Proteome Res, 2020 Jan 3. PMID 31789040

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dld2 and Dld3, both currently annotated as D-lactate dehydrogenases, efficiently oxidized d-2-hydroxyglutarate to alpha-ketoglutarate.
      Title: Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables (D)-2-hydroxyglutarate-pyruvate transhydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables (D)-2-hydroxyglutarate-pyruvate transhydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables D-lactate dehydrogenase (cytochrome) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-lactate dehydrogenase (cytochrome) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in filamentous growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lactate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    D-lactate dehydrogenase
    NP_010843.1
    • 2-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase; converts D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate in the presence of FAD, with concomitant reduction of pyruvate to D-lactate; minor lactate dehydrogenase activity; component of the retrograde regulon that consists of genes whose expression are stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source; located in the cytoplasm

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      16355..17845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178886.1 → NP_010843.1  TPA: D-lactate dehydrogenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010843.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLI0, P39976
      UniProtKB/TrEMBL
      A6ZQN2, B3LRU9, B5VH67, C7GQ34, C8ZFV1, G2WCG3, N1P7B4
      Conserved Domains (1) summary
      COG0277
      Location:34 → 496
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39976.1

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