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    SGF29 Sgf29p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850347, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SGF29
    Official Full Name
    Sgf29p
    Primary source
    SGD:S000000516
    Locus tag
    YCL010C
    See related
    AllianceGenome:SGD:S000000516; FungiDB:YCL010C; VEuPathDB:YCL010C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables methylated histone binding activity. Involved in several processes, including SAGA complex localization to transcription regulatory region; histone H3 acetylation; and positive regulation of transcription by RNA polymerase II. Part of ADA complex and SAGA complex. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human SGF29 (SAGA complex associated factor 29). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SGF29 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (103571..104350, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene single-stranded telomeric DNA-binding/mRNA-binding protein Neighboring gene acetolactate synthase regulatory subunit Neighboring gene ubiquitin-binding ESCRT-I subunit protein STP22

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sgf29p facilitates the recruitment of TATA box binding protein but does not alter SAGA's global structural integrity in vivo. Shukla A, et al. Biochemistry, 2012 Jan 17. PMID 22224423, Free PMC Article
    2. Cloning, purification, crystallization and preliminary crystallographic analysis of the tandem tudor domain of Sgf29 from Saccharomyces cerevisiae. Li J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Aug 1. PMID 20693663, Free PMC Article
    3. Synthetic protein interactions reveal a functional map of the cell. Berry LK, et al. Elife, 2016 Apr 21. PMID 27098839, Free PMC Article
    4. The Spt7 subunit of the SAGA complex is required for the regulation of lifespan in both dividing and nondividing yeast cells. Lim S, et al. Mech Ageing Dev, 2021 Jun. PMID 33831401
    5. NuA4 and SAGA acetyltransferase complexes cooperate for repair of DNA breaks by homologous recombination. Cheng X, et al. PLoS Genet, 2021 Jul. PMID 34228704, Free PMC Article

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. tandem tudor domain at the C-terminus of Sgf29 was crystallized using the hanging-drop vapour-diffusion method and the crystals diffracted to 1.92 A resolution
      Title: Cloning, purification, crystallization and preliminary crystallographic analysis of the tandem tudor domain of Sgf29 from Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SAGA complex localization to transcription regulatory region IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ADA complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of ADA complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sgf29p
    NP_009917.1
    • Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      103571..104350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178659.1 → NP_009917.1  TPA: Sgf29p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009917.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR02, P25554, P87008
      UniProtKB/TrEMBL
      B3LU65, B5VEU2, N1P677
      Conserved Domains (1) summary
      pfam07039
      Location:127 → 250
      DUF1325; SGF29 tudor-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25554.2

    Gene LinkOut

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