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    NOC3 Noc3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850688, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NOC3
    Official Full Name
    Noc3p
    Primary source
    SGD:S000003992
    Locus tag
    YLR002C
    See related
    AllianceGenome:SGD:S000003992; FungiDB:YLR002C; VEuPathDB:YLR002C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables chromatin binding activity. Involved in DNA-dependent DNA replication and ribosome biogenesis. Located in nucleolus and nucleoplasm. Part of Noc2p-Noc3p complex and nuclear pre-replicative complex. Orthologous to human NOC3L (NOC3 like DNA replication regulator). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NOC3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (154343..156334, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene dynamin-related GTPase DNM1 Neighboring gene uncharacterized protein Neighboring gene Cms1p Neighboring gene Thi73p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. Milkereit P, et al. Cell, 2001 May 18. PMID 11371346
    2. The Noc proteins involved in ribosome synthesis and export contain divergent HEAT repeats. Dlakić M, et al. RNA, 2004 Mar. PMID 14970380, Free PMC Article
    3. Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast. Zhang Y, et al. Cell, 2002 Jun 28. PMID 12110182
    4. The nucle(ol)ar Tif6p and Efl1p are required for a late cytoplasmic step of ribosome synthesis. Senger B, et al. Mol Cell, 2001 Dec. PMID 11779510
    5. Eukaryotic nuclear structure explains the evolutionary rate difference of ribosome export factors. Ohyanagi H, et al. Gene, 2008 Sep 15. PMID 18588954

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An essential Noc3p dimerization cycle mediates ORC double-hexamer formation in replication licensing.
      Title: An essential Noc3p dimerization cycle mediates ORC double-hexamer formation in replication licensing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pre-replicative complex assembly involved in nuclear cell cycle DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Noc2p-Noc3p complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pre-replicative complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Noc3p
    NP_013102.1
    • Subunit of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      154343..156334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181889.1 → NP_013102.1  TPA: Noc3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013102.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY04, Q07896, Q92280
      UniProtKB/TrEMBL
      A7A0Q7, B3LTG7, B5VMU3, C7GPF6, C8ZCX4
      Conserved Domains (1) summary
      COG5117
      Location:1 → 660
      NOC3; Protein involved in the nuclear export of pre-ribosomes [Translation, ribosomal structure and biogenesis / Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07896.1

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