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    DHRS11 dehydrogenase/reductase 11 [ Homo sapiens (human) ]

    Gene ID: 79154, updated on 28-Oct-2024

    Summary

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    Official Symbol
    DHRS11provided by HGNC
    Official Full Name
    dehydrogenase/reductase 11provided by HGNC
    Primary source
    HGNC:HGNC:28639
    See related
    Ensembl:ENSG00000278535 MIM:616159; AllianceGenome:HGNC:28639
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARPG836; SDR24C1; spDHRS11
    Summary
    Enables 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in steroid biosynthetic process. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in duodenum (RPKM 115.7), small intestine (RPKM 99.1) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DHRS11 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (36591879..36600804)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (37578223..37587148)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34948309..34957233)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene myosin XIX Neighboring gene phosphatidylinositol glycan anchor biosynthesis class W Neighboring gene gametogenetin binding protein 2 Neighboring gene ribosomal protein S2 pseudogene 50 Neighboring gene uncharacterized LOC107985031 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34983260-34983760 Neighboring gene mitochondrial rRNA methyltransferase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34998295-34999169 Neighboring gene MPRA-validated peak2825 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35010359-35010858 Neighboring gene VISTA enhancer hs362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35013913-35014450 Neighboring gene uncharacterized LOC105371750 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:35018784-35018989 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35021739-35022238 Neighboring gene uncharacterized LOC105371751

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C(19)-steroids. Endo S, et al. J Steroid Biochem Mol Biol, 2020 May. PMID 31926269
    2. Human dehydrogenase/reductase (SDR family) member 11 is a novel type of 17β-hydroxysteroid dehydrogenase. Endo S, et al. Biochem Biophys Res Commun, 2016 Mar 25. PMID 26920053
    3. Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1 complex targets ATXN1 to trigger NF-κB-dependent inflammation response. Lou LQ, et al. J Mol Med (Berl), 2023 Mar. PMID 36629882
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
    5. Panorama of ancient metazoan macromolecular complexes. Wan C, et al. Nature, 2015 Sep 17. PMID 26344197, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C19-steroids.
      Title: Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C(19)-steroids.
    2. The recombinant protein (DHRS11) efficiently catalyzed the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5alpha-androstanes into their 17beta-hydroxyl metabolites with NADPH as a coenzyme.
      Title: Human dehydrogenase/reductase (SDR family) member 11 is a novel type of 17β-hydroxysteroid dehydrogenase.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC4172, FLJ39232

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 17-beta-ketosteroid reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-keto sterol reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in estrogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in steroid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dehydrogenase/reductase SDR family member 11
    Names
    17-beta-hydroxysteroid dehydrogenase
    3-beta-hydroxysteroid 3-dehydrogenase
    dehydrogenase/reductase (SDR family) member 11
    estradiol 17-beta-dehydrogenase
    short-chain dehydrogenase/reductase family 24C member 1
    NP_077284.2
    XP_005257715.1
    XP_011523535.1
    XP_047292688.1
    XP_054173159.1
    XP_054173160.1
    XP_054173161.1
    XP_054185307.1
    XP_054185308.1
    XP_054185309.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024308.4 → NP_077284.2  dehydrogenase/reductase SDR family member 11 precursor

      See identical proteins and their annotated locations for NP_077284.2

      Status: VALIDATED

      Source sequence(s)
      AY358712, BG037061
      Consensus CDS
      CCDS11315.2
      UniProtKB/Swiss-Prot
      A0A0U5BLD0, B2RDZ3, Q6UWP2, Q9BUC7, Q9H674
      Related
      ENSP00000482704.1, ENST00000618403.5
      Conserved Domains (1) summary
      cd05343
      Location:6 → 256
      Mgc4172-like_SDR_c; human Mgc4172-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      36591879..36600804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257658.4 → XP_005257715.1  dehydrogenase/reductase SDR family member 11 isoform X1

      See identical proteins and their annotated locations for XP_005257715.1

      UniProtKB/Swiss-Prot
      Q6UWP2
      Conserved Domains (1) summary
      cd05343
      Location:6 → 225
      Mgc4172-like_SDR_c; human Mgc4172-like, classical (c) SDRs

    2. XM_011525233.3 → XP_011523535.1  dehydrogenase/reductase SDR family member 11 isoform X2

      See identical proteins and their annotated locations for XP_011523535.1

      Conserved Domains (2) summary
      COG4221
      Location:6 → 189
      YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
      cl21454
      Location:6 → 186
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. XM_047436732.1 → XP_047292688.1  dehydrogenase/reductase SDR family member 11 isoform X3

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      827374..836298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329332.1 → XP_054185307.1  dehydrogenase/reductase SDR family member 11 isoform X1

    2. XM_054329333.1 → XP_054185308.1  dehydrogenase/reductase SDR family member 11 isoform X2

    3. XM_054329334.1 → XP_054185309.1  dehydrogenase/reductase SDR family member 11 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      37578223..37587148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317184.1 → XP_054173159.1  dehydrogenase/reductase SDR family member 11 isoform X1

    2. XM_054317185.1 → XP_054173160.1  dehydrogenase/reductase SDR family member 11 isoform X2

    3. XM_054317186.1 → XP_054173161.1  dehydrogenase/reductase SDR family member 11 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UWP2.1 GenPept UniProtKB/Swiss-Prot:Q6UWP2

    Gene LinkOut

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