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    OLIG1 oligodendrocyte transcription factor 1 [ Homo sapiens (human) ]

    Gene ID: 116448, updated on 2-Nov-2024

    Summary

    Official Symbol
    OLIG1provided by HGNC
    Official Full Name
    oligodendrocyte transcription factor 1provided by HGNC
    Primary source
    HGNC:HGNC:16983
    See related
    Ensembl:ENSG00000184221 MIM:606385; AllianceGenome:HGNC:16983
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BHLHB6; BHLHE21
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Predicted to be involved in axon development; positive regulation of transcription by RNA polymerase II; and sensory organ development. Predicted to act upstream of or within neuron fate commitment. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See OLIG1 in Genome Data Viewer
    Location:
    21q22.11
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (33070141..33072413)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (31438351..31440623)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (34442447..34444719)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:34398072-34398974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:34405338-34406006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:34406007-34406674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:34408273-34408826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:34408827-34409379 Neighboring gene oligodendrocyte transcription factor 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:34414306-34415505 Neighboring gene long intergenic non-protein coding RNA 945 Neighboring gene VISTA enhancer hs1346 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:34477251-34477777 Neighboring gene uncharacterized LOC101928107 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:34487678-34488212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:34524357-34524877 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:34524878-34525397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18367 Neighboring gene long intergenic non-protein coding RNA 1548

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables E-box binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in axon development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oligodendrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    oligodendrocyte transcription factor 1
    Names
    basic domain, helix-loop-helix protein, class B, 6
    class B basic helix-loop-helix protein 6
    class E basic helix-loop-helix protein 21
    oligo1
    oligodendrocyte lineage transcription factor 1
    oligodendrocyte-specific bHLH transcription factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138983.3NP_620450.2  oligodendrocyte transcription factor 1

      See identical proteins and their annotated locations for NP_620450.2

      Status: VALIDATED

      Source sequence(s)
      AL355743, AL834450, AP000289, BC033290
      Consensus CDS
      CCDS42920.2
      UniProtKB/Swiss-Prot
      Q7RTS0, Q8TAK6
      UniProtKB/TrEMBL
      Q59EM0
      Related
      ENSP00000371785.1, ENST00000382348.2
      Conserved Domains (1) summary
      pfam00010
      Location:107164
      HLH; Helix-loop-helix DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      33070141..33072413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      31438351..31440623
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)