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    GPR132 G protein-coupled receptor 132 [ Homo sapiens (human) ]

    Gene ID: 29933, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GPR132provided by HGNC
    Official Full Name
    G protein-coupled receptor 132provided by HGNC
    Primary source
    HGNC:HGNC:17482
    See related
    Ensembl:ENSG00000183484 MIM:606167; AllianceGenome:HGNC:17482
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G2A
    Summary
    This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
    Expression
    Broad expression in appendix (RPKM 4.0), lymph node (RPKM 3.6) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR132 in Genome Data Viewer
    Location:
    14q32.33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (105049395..105065430, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (99293953..99309986, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105515732..105531767, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6209 Neighboring gene clathrin binding box of aftiphilin containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105485485-105486145 Neighboring gene H3K27ac hESC enhancers GRCh37_chr14:105486597-105487112 and GRCh37_chr14:105487627-105488140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9128 Neighboring gene Sharpr-MPRA regulatory region 5751 Neighboring gene cell division cycle associated 4 Neighboring gene uncharacterized LOC124903398 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105499947-105500448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105521947-105522722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9134 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105532273-105532790 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9138 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:105536095-105537294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105544057-105544557 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:105544918-105545868 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6215 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6216 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6217 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6218 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105560015-105560637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9140 Neighboring gene long intergenic non-protein coding RNA 2298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105585919-105586418 Neighboring gene jagged canonical Notch ligand 2 Neighboring gene microRNA 6765

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis. Lin P, et al. J Biol Chem, 2003 Apr 18. PMID 12586833
    2. G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine. Murakami N, et al. J Biol Chem, 2004 Oct 8. PMID 15280385
    3. Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A. Obinata H, et al. J Biol Chem, 2005 Dec 9. PMID 16236715
    4. Therapeutic options for transfusion related acute lung injury; the potential of the G2A receptor. Ellison MA, et al. Curr Pharm Des, 2012. PMID 22621271, Free PMC Article
    5. Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A. Frasch SC, et al. J Immunol, 2007 May 15. PMID 17475884

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia.
      Title: Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia.
    2. Lipid Receptor G2A-Mediated Signal Pathway Plays a Critical Role in Inflammatory Response by Promoting Classical Macrophage Activation.
      Title: Lipid Receptor G2A-Mediated Signal Pathway Plays a Critical Role in Inflammatory Response by Promoting Classical Macrophage Activation.
    3. Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors.
      Title: Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors.
    4. G protein-coupled receptor 132 (Gpr132) functions as a key macrophage sensor of the rising lactate in the acidic tumor milieu to mediate the reciprocal interaction between cancer cells and macrophages during breast cancer metastasis. Lactate activates macrophage Gpr132 to promote the alternatively activated macrophage (M2)-like phenotype, which, in turn, facilitates cancer cell adhesion, migration, and invasion.
      Title: Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis.
    5. High GPR132 expression is associated with acute lymphoblastic leukemia.
      Title: Direct interaction of Ikaros and Foxp1 modulates expression of the G protein-coupled receptor G2A in B-lymphocytes and acute lymphoblastic leukemia.
    6. coexpression of OGR1- and G2A-enhanced proton sensitivity and proton-induced calcium signals. This alteration is attributed to oligomerization of OGR1 and G2A. The oligomeric potential locates receptors at a specific site, which leads to enhanced
      Title: Heteromerization of G2A and OGR1 enhances proton sensitivity and proton-induced calcium signals.
    7. Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator)
      Title: Integrative predictive model of coronary artery calcification in atherosclerosis.
    8. we found an additional novel G2A variant (G2A-b) that is the major transcript with functional response to ligand stimulation as well as G2A-a, and succeeded in discriminating proton-sensing and oxidized fatty acid-sensing activities of G2A.
      Title: Identification and analysis of two splice variants of human G2A generated by alternative splicing.
    9. 9-HODE-G2A signaling plays proinflammatory roles in skin under oxidative conditions
      Title: G2A plays proinflammatory roles in human keratinocytes under oxidative stress as a receptor for 9-hydroxyoctadecadienoic acid.
    10. the G-protein-coupled receptor G2A, unlike its relative GPR4, is involved in the chemotaxis of monocytic cells.
      Title: Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    General gene information

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    Markers

    Potential readthrough

    Included gene: CDCA4

    Homology

    Clone Names

    • MGC99642

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 132
    Names
    G2 accumulation protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278694.2 → NP_001265623.1  probable G-protein coupled receptor 132 isoform 1

      See identical proteins and their annotated locations for NP_001265623.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK292142, BC084546
      Consensus CDS
      CCDS9997.1
      UniProtKB/Swiss-Prot
      A8K7X7, B4E144, Q9BSU2, Q9UNW8
      UniProtKB/TrEMBL
      B2LM89
      Related
      ENSP00000438094.2, ENST00000539291.6
      Conserved Domains (1) summary
      cd15364
      Location:43 → 319
      7tmA_GPR132_G2A; proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001278695.2 → NP_001265624.1  probable G-protein coupled receptor 132 isoform 2

      See identical proteins and their annotated locations for NP_001265624.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA714520, AB465600
      Consensus CDS
      CCDS61567.1
      UniProtKB/TrEMBL
      B2LM89
      Related
      ENSP00000376364.2, ENST00000392585.2
      Conserved Domains (1) summary
      pfam00001
      Location:85 → 299
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. NM_001278696.2 → NP_001265625.1  probable G-protein coupled receptor 132 isoform 3

      See identical proteins and their annotated locations for NP_001265625.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      BC084546, DB137292
      UniProtKB/Swiss-Prot
      Q9UNW8
      Conserved Domains (1) summary
      pfam00001
      Location:16 → 120
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    4. NM_013345.4 → NP_037477.1  probable G-protein coupled receptor 132 isoform 1

      See identical proteins and their annotated locations for NP_037477.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AA714520, AB465599
      Consensus CDS
      CCDS9997.1
      UniProtKB/Swiss-Prot
      A8K7X7, B4E144, Q9BSU2, Q9UNW8
      UniProtKB/TrEMBL
      B2LM89
      Related
      ENSP00000328818.3, ENST00000329797.8
      Conserved Domains (1) summary
      cd15364
      Location:43 → 319
      7tmA_GPR132_G2A; proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      105049395..105065430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      99293953..99309986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UNW8.1 GenPept UniProtKB/Swiss-Prot:Q9UNW8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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