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    Riok3 RIO kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 66878, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Riok3provided by MGI
    Official Full Name
    RIO kinase 3provided by MGI
    Primary source
    MGI:MGI:1914128
    See related
    Ensembl:ENSMUSG00000024404 AllianceGenome:MGI:1914128
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sudd; D18Ertd331e; 1200013N13Rik; E130306C24Rik
    Summary
    Predicted to enable caspase binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to dsDNA; negative regulation of intracellular signal transduction; and positive regulation of interferon-beta production. Predicted to be located in cytoplasm. Predicted to be part of preribosome, small subunit precursor. Predicted to be active in cytosol. Is expressed in ganglia; sensory organ; trigeminal nerve; and vibrissa. Orthologous to human RIOK3 (RIO kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 11.9), CNS E11.5 (RPKM 11.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Riok3 in Genome Data Viewer
    Location:
    18 A1; 18 6.15 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (12259114..12290424)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (12126091..12157367)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 241 Neighboring gene STARR-seq mESC enhancer starr_43825 Neighboring gene STARR-seq mESC enhancer starr_43827 Neighboring gene STARR-seq mESC enhancer starr_43828 Neighboring gene STARR-seq mESC enhancer starr_43830 Neighboring gene STARR-positive B cell enhancer ABC_E4239 Neighboring gene predicted gene, 41667 Neighboring gene STARR-positive B cell enhancer ABC_E3223 Neighboring gene predicted gene, 25289 Neighboring gene predicted gene, 19293 Neighboring gene regulator of MON1-CCZ1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RIOK3 potentially regulates osteogenesis-related pathways in ankylosing spondylitis and the differentiation of bone marrow mesenchymal stem cells. Zong HX, et al. Genomics, 2023 Nov. PMID 37866658
    2. miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1. Zhang L, et al. Genes Dev, 2011 Jan 15. PMID 21196494, Free PMC Article
    3. Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation. Shen Y, et al. Cell Rep, 2021 Jun 22. PMID 34161773, Free PMC Article
    4. Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay. Darakhshan F, et al. Carcinogenesis, 2006 Feb. PMID 16093251
    5. The RIO kinases: an atypical protein kinase family required for ribosome biogenesis and cell cycle progression. LaRonde-LeBlanc N, et al. Biochim Biophys Acta, 2005 Dec 30. PMID 16182620

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RIOK3 potentially regulates osteogenesis-related pathways in ankylosing spondylitis and the differentiation of bone marrow mesenchymal stem cells.
      Title: RIOK3 potentially regulates osteogenesis-related pathways in ankylosing spondylitis and the differentiation of bone marrow mesenchymal stem cells.
    2. Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.
      Title: Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.
    3. down-regulation of miR-191 is essential for erythroid chromatin condensation and enucleation by allowing up-regulation of Riok3 and Mxi1
      Title: miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables caspase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables caspase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to dsDNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to dsDNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to dsRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to dsRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of SSU-rRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of MDA-5 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of MDA-5 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interferon-beta production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, small subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, small subunit precursor IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, small subunit precursor ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase RIO3
    Names
    sudD, suppressor of bimD6 homolog
    NP_077144.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024182.4 → NP_077144.2  serine/threonine-protein kinase RIO3

      See identical proteins and their annotated locations for NP_077144.2

      Status: PROVISIONAL

      Source sequence(s)
      AK147074
      Consensus CDS
      CCDS29062.1
      UniProtKB/Swiss-Prot
      Q3UI51, Q8CIC1, Q9DBU3
      UniProtKB/TrEMBL
      Q3TJT2, Q3UYW1, Q3V2R6
      Related
      ENSMUSP00000025270.7, ENSMUST00000025270.8
      Conserved Domains (2) summary
      COG1718
      Location:214 → 461
      RIO1; Serine/threonine-protein kinase RIO1 [Signal transduction mechanisms]
      cd05146
      Location:253 → 453
      RIO3_euk; Catalytic domain of the atypical protein serine kinase, RIO3 kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      12259114..12290424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001782390.3 RNA Sequence

    2. XR_003952538.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBU3.3 GenPept UniProtKB/Swiss-Prot:Q9DBU3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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