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    Trio triple functional domain (PTPRF interacting) [ Mus musculus (house mouse) ]

    Gene ID: 223435, updated on 14-Nov-2024

    Summary

    Official Symbol
    Trioprovided by MGI
    Official Full Name
    triple functional domain (PTPRF interacting)provided by MGI
    Primary source
    MGI:MGI:1927230
    See related
    Ensembl:ENSMUSG00000022263 AllianceGenome:MGI:1927230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Solo; 6720464I07Rik
    Summary
    Predicted to enable enzyme binding activity and guanyl-nucleotide exchange factor activity. Involved in negative regulation of fat cell differentiation. Predicted to be located in cell projection and early endosome. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic active zone. Predicted to be extrinsic component of membrane. Is expressed in central nervous system and dorsal root ganglion. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and autosomal dominant intellectual developmental disorder 44. Orthologous to human TRIO (trio Rho guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 17.6), CNS E18 (RPKM 15.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Trio in Genome Data Viewer
    Location:
    15 B1; 15 10.4 cM
    Exon count:
    62
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (27730735..28025954, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (27730649..28025848, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46506 Neighboring gene STARR-seq mESC enhancer starr_38229 Neighboring gene OTU deubiquitinase with linear linkage specificity like Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:27725815-27725968 Neighboring gene STARR-positive B cell enhancer ABC_E11588 Neighboring gene STARR-seq mESC enhancer starr_38230 Neighboring gene STARR-seq mESC enhancer starr_38231 Neighboring gene STARR-seq mESC enhancer starr_38233 Neighboring gene STARR-positive B cell enhancer ABC_E5471 Neighboring gene STARR-seq mESC enhancer starr_38236 Neighboring gene STARR-seq mESC enhancer starr_38238 Neighboring gene STARR-seq mESC enhancer starr_38239 Neighboring gene STARR-seq mESC enhancer starr_38240 Neighboring gene STARR-seq mESC enhancer starr_38241 Neighboring gene predicted gene, 29975 Neighboring gene STARR-seq mESC enhancer starr_38243 Neighboring gene STARR-seq mESC enhancer starr_38244 Neighboring gene predicted gene, 19883 Neighboring gene predicted gene, 31458

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (7)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in postsynaptic modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in postsynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extrinsic component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    triple functional domain protein
    NP_001074771.1
    XP_006520113.1
    XP_006520114.1
    XP_006520115.1
    XP_006520116.1
    XP_006520117.1
    XP_030104327.1
    XP_036015215.1
    XP_036015216.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081302.1NP_001074771.1  triple functional domain protein

      Status: VALIDATED

      Source sequence(s)
      AB106872, BC051169, BC060724, BY727751, CF539743
      Consensus CDS
      CCDS49587.1
      UniProtKB/Swiss-Prot
      Q0KL02, Q3U522, Q6P9K6, Q80W23
      Related
      ENSMUSP00000087714.6, ENSMUST00000090247.7
      Conserved Domains (14) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16591718
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:25592617
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00220
      Location:28003054
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00516
      Location:69204
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:19702143
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:567783
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam07679
      Location:26892780
      I-set; Immunoglobulin I-set domain
      cd13240
      Location:14721594
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21482286
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14113
      Location:27923054
      STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
      pfam00169
      Location:21752271
      PH; PH domain
      pfam16609
      Location:17151972
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cl11960
      Location:27032780
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      27730735..28025954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520051.5XP_006520114.1  triple functional domain protein isoform X2

      UniProtKB/Swiss-Prot
      Q0KL02, Q3U522, Q6P9K6, Q80W23
      Conserved Domains (11) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16591718
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:25592617
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:69204
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:19702143
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:567783
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14721594
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21482286
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14113
      Location:27883050
      STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
      pfam07679
      Location:26852776
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17161963
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    2. XM_036159323.1XP_036015216.1  triple functional domain protein isoform X7

      UniProtKB/Swiss-Prot
      Q0KL02, Q3U522, Q6P9K6, Q80W23
      Conserved Domains (12) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16591718
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:25592617
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:69204
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:19702143
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:567783
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14721594
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21482286
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam07679
      Location:26892780
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17151972
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:26972700
      Ig; Ig strand A' [structural motif]
      cl21453
      Location:27922875
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006520053.5XP_006520116.1  triple functional domain protein isoform X5

      UniProtKB/Swiss-Prot
      Q0KL02, Q3U522, Q6P9K6, Q80W23
      Conserved Domains (11) summary
      smart00150
      Location:11041204
      SPEC; Spectrin repeats
      cd11852
      Location:16201679
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:25202578
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:30165
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:19312104
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:528744
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14331555
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21092247
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14113
      Location:27533015
      STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
      pfam07679
      Location:26502741
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:16771924
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    4. XM_036159322.1XP_036015215.1  triple functional domain protein isoform X4

      UniProtKB/Swiss-Prot
      Q0KL02, Q3U522, Q6P9K6, Q80W23
      Conserved Domains (12) summary
      smart00150
      Location:11111211
      SPEC; Spectrin repeats
      cd11852
      Location:16271686
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:25272585
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:37172
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:19382111
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:535751
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14401562
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21162254
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14113
      Location:27603022
      STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
      pfam07679
      Location:26572748
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:16831940
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      cd00096
      Location:26652668
      Ig; Ig strand A' [structural motif]
    5. XM_030248467.1XP_030104327.1  triple functional domain protein isoform X6

      UniProtKB/Swiss-Prot
      Q0KL02, Q3U522, Q6P9K6, Q80W23
      Conserved Domains (11) summary
      smart00150
      Location:10841184
      SPEC; Spectrin repeats
      cd11852
      Location:16001659
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:25002558
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:10145
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:19112084
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:508724
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14131535
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:20892227
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14113
      Location:27332995
      STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
      pfam07679
      Location:26302721
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:16571904
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    6. XM_006520052.4XP_006520115.1  triple functional domain protein isoform X3

      UniProtKB/Swiss-Prot
      Q0KL02, Q3U522, Q6P9K6, Q80W23
      Conserved Domains (11) summary
      smart00150
      Location:11181218
      SPEC; Spectrin repeats
      cd11852
      Location:16341693
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:25342592
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:44179
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:19452118
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:542758
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14471569
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21232261
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14113
      Location:27673029
      STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
      pfam07679
      Location:26642755
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:16911938
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    7. XM_006520050.5XP_006520113.1  triple functional domain protein isoform X1

      UniProtKB/Swiss-Prot
      Q0KL02, Q3U522, Q6P9K6, Q80W23
      Conserved Domains (11) summary
      smart00150
      Location:11421242
      SPEC; Spectrin repeats
      cd11852
      Location:16581717
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:25582616
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:68203
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:19692142
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:566782
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14711593
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21472285
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14113
      Location:27913053
      STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
      pfam07679
      Location:26882779
      I-set; Immunoglobulin I-set domain
      pfam16609
      Location:17151962
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    8. XM_006520054.5XP_006520117.1  triple functional domain protein isoform X8

      UniProtKB/TrEMBL
      A0A2I3BRP6
      Related
      ENSMUSP00000154653.2, ENSMUST00000227337.2
      Conserved Domains (7) summary
      smart00150
      Location:11431243
      SPEC; Spectrin repeats
      cd11852
      Location:16591718
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:69204
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:12951465
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:567783
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14721594
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      pfam16609
      Location:17161889
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    RNA

    1. XR_004938814.1 RNA Sequence

    2. XR_004938815.1 RNA Sequence

    3. XR_001781509.3 RNA Sequence

    4. XR_001781508.3 RNA Sequence