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    Ube2d2 ubiquitin-conjugating enzyme E2D 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 641452, updated on 2-May-2024

    Summary

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    Official Symbol
    Ube2d2provided by RGD
    Official Full Name
    ubiquitin-conjugating enzyme E2D 2provided by RGD
    Primary source
    RGD:1591897
    See related
    Ensembl:ENSRNOG00000069286 AllianceGenome:RGD:1591897
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ubc2e; E217kB
    Summary
    Enables ubiquitin-protein transferase activity. Predicted to be involved in protein K11-linked ubiquitination; protein K48-linked ubiquitination; and protein autoubiquitination. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human UBE2D2 (ubiquitin conjugating enzyme E2 D2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 387.1), Thymus (RPKM 315.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ube2d2 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (27638399..27680386)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (27364325..27406322)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (28561957..28603335)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098144 Neighboring gene stimulator of interferon response cGAMP interactor 1 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene CXXC finger protein 5 Neighboring gene uncharacterized LOC134482928 Neighboring gene ribosomal protein S16, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. UBE2D2 is not involved in MuRF1-dependent muscle wasting during hindlimb suspension. Polge C, et al. Int J Biochem Cell Biol, 2016 Oct. PMID 27378730
    2. A novel rat homolog of the Saccharomyces cerevisiae ubiquitin-conjugating enzymes UBC4 and UBC5 with distinct biochemical features is induced during spermatogenesis. Wing SS, et al. Mol Cell Biol, 1996 Aug. PMID 8754804, Free PMC Article
    3. Molecular cloning, expression and characterization of a ubiquitin conjugation enzyme (E2(17)kB) highly expressed in rat testis. Wing SS, et al. Biochem J, 1995 Jan 1. PMID 7826319, Free PMC Article
    4. Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation. Chiang MH, et al. Biol Reprod, 2008 Nov. PMID 18703417
    5. Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor. Grou CP, et al. J Biol Chem, 2008 May 23. PMID 18359941

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UBE2D2 is not the cognate ubiquitinating enzyme for MuRF1
      Title: UBE2D2 is not involved in MuRF1-dependent muscle wasting during hindlimb suspension.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 D2
    Names
    (E3-independent) E2 ubiquitin-conjugating enzyme D2
    E2 ubiquitin-conjugating enzyme D2
    E2(17)KB 2
    ubc2e ubiquitin conjugating enzyme
    ubiquitin carrier protein D2
    ubiquitin-conjugating enzyme E2(17)KB 2
    ubiquitin-conjugating enzyme E2-17 kDa 2
    ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
    ubiquitin-protein ligase D2
    NP_001380701.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393772.1 → NP_001380701.1  ubiquitin-conjugating enzyme E2 D2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      P62839
      UniProtKB/TrEMBL
      A0A0G2K739, A6J2Z6
      Related
      ENSRNOP00000088484.1, ENSRNOT00000095794.1
      Conserved Domains (1) summary
      cl00154
      Location:1 → 146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      27638399..27680386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037292.1: Suppressed sequence

      Description
      NM_001037292.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62839.1 GenPept UniProtKB/Swiss-Prot:P62839

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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