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    Fam193b family with sequence similarity 193, member B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498703, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fam193bprovided by RGD
    Official Full Name
    family with sequence similarity 193, member Bprovided by RGD
    Primary source
    RGD:1562335
    See related
    EnsemblRapid:ENSRNOG00000039807 AllianceGenome:RGD:1562335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562335
    Summary
    Predicted to be located in nuclear speck and nucleolus. Predicted to be active in cytoplasm and nucleus. Orthologous to human FAM193B (family with sequence similarity 193 member B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 85.2), Lung (RPKM 73.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fam193b in Genome Data Viewer
    Location:
    17p14
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (9071974..9104659)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9066818..9099511)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9595742..9628414)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene beta-1,4-galactosyltransferase 7 Neighboring gene transmembrane p24 trafficking protein 9 Neighboring gene uncharacterized LOC108348505 Neighboring gene DEAD-box helicase 41 Neighboring gene microRNA 3542 Neighboring gene docking protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. IRIZIO: a novel gene cooperating with PAX3-FOXO1 in alveolar rhabdomyosarcoma (ARMS). Picchione F, et al. Carcinogenesis, 2011 Apr. PMID 21177767, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM193B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170408.1 → NP_001163879.1  protein FAM193B

      See identical proteins and their annotated locations for NP_001163879.1

      Status: VALIDATED

      Source sequence(s)
      BC166819, CB717749, CB719022, DN936834
      UniProtKB/TrEMBL
      A0A8I6G5I0, D3ZDR1
      Related
      ENSRNOP00000017350.5, ENSRNOT00000017349.8
      Conserved Domains (3) summary
      PHA03247
      Location:128 → 192
      PHA03247; large tegument protein UL36; Provisional
      cl30717
      Location:567 → 701
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
      pfam15914
      Location:722 → 771
      FAM193_C; FAM193 family C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      9071974..9104659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096002.2 → XP_038951930.1  protein FAM193B isoform X7

      Conserved Domains (3) summary
      PTZ00449
      Location:242 → 472
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl30717
      Location:372 → 506
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
      pfam15914
      Location:527 → 576
      FAM193_C; FAM193 family C-terminal

    2. XM_039096003.2 → XP_038951931.1  protein FAM193B isoform X8

      Conserved Domains (1) summary
      PHA03247
      Location:241 → 305
      PHA03247; large tegument protein UL36; Provisional

    3. XM_006253646.4 → XP_006253708.1  protein FAM193B isoform X1

      UniProtKB/TrEMBL
      A0A8I6A731, A0A8I6AF06
      Related
      ENSRNOP00000088708.1, ENSRNOT00000117137.2
      Conserved Domains (3) summary
      PHA03247
      Location:241 → 305
      PHA03247; large tegument protein UL36; Provisional
      cl30717
      Location:680 → 814
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
      pfam15914
      Location:835 → 884
      FAM193_C; FAM193 family C-terminal

    4. XM_039095995.2 → XP_038951923.1  protein FAM193B isoform X3

      UniProtKB/TrEMBL
      A0A8I6AF06, A0A8I6B4R3
      Related
      ENSRNOP00000096762.1, ENSRNOT00000100699.2
      Conserved Domains (3) summary
      PHA03247
      Location:160 → 224
      PHA03247; large tegument protein UL36; Provisional
      cl30717
      Location:599 → 733
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
      pfam15914
      Location:754 → 803
      FAM193_C; FAM193 family C-terminal

    5. XM_039096004.2 → XP_038951932.1  protein FAM193B isoform X9

      UniProtKB/TrEMBL
      B2RYL2
      Related
      ENSRNOP00000068724.1, ENSRNOT00000089990.3
      Conserved Domains (2) summary
      cl30717
      Location:251 → 385
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
      pfam15914
      Location:406 → 455
      FAM193_C; FAM193 family C-terminal

    6. XM_017600642.3 → XP_017456131.1  protein FAM193B isoform X2

      UniProtKB/TrEMBL
      A0A8I6ATD9, A0A8I6G5I0
      Conserved Domains (1) summary
      pfam15914
      Location:769 → 818
      FAM193_C; FAM193 family C-terminal

    7. XM_039096000.1 → XP_038951928.1  protein FAM193B isoform X5

      UniProtKB/TrEMBL
      A0A8I6G5I0
      Conserved Domains (3) summary
      PHA03247
      Location:96 → 160
      PHA03247; large tegument protein UL36; Provisional
      cl30717
      Location:535 → 669
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
      pfam15914
      Location:690 → 739
      FAM193_C; FAM193 family C-terminal

    8. XM_039096001.2 → XP_038951929.1  protein FAM193B isoform X5

      UniProtKB/TrEMBL
      A0A8I6G5I0
      Conserved Domains (3) summary
      PHA03247
      Location:96 → 160
      PHA03247; large tegument protein UL36; Provisional
      cl30717
      Location:535 → 669
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
      pfam15914
      Location:690 → 739
      FAM193_C; FAM193 family C-terminal

    9. XM_039095996.2 → XP_038951924.1  protein FAM193B isoform X4

      UniProtKB/TrEMBL
      A0A8I6G5I0, D3ZDR1
      Conserved Domains (3) summary
      PHA03247
      Location:128 → 192
      PHA03247; large tegument protein UL36; Provisional
      cl30717
      Location:567 → 701
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
      pfam15914
      Location:722 → 771
      FAM193_C; FAM193 family C-terminal

    10. XM_006253651.5 → XP_006253713.1  protein FAM193B isoform X5

      UniProtKB/TrEMBL
      A0A8I6G5I0
      Conserved Domains (3) summary
      PHA03247
      Location:96 → 160
      PHA03247; large tegument protein UL36; Provisional
      cl30717
      Location:535 → 669
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
      pfam15914
      Location:690 → 739
      FAM193_C; FAM193 family C-terminal

    11. XM_063276686.1 → XP_063132756.1  protein FAM193B isoform X6

      UniProtKB/TrEMBL
      A6KAR0

    12. XM_039095998.2 → XP_038951926.1  protein FAM193B isoform X4

      UniProtKB/TrEMBL
      A0A8I6G5I0, D3ZDR1
      Conserved Domains (3) summary
      PHA03247
      Location:128 → 192
      PHA03247; large tegument protein UL36; Provisional
      cl30717
      Location:567 → 701
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
      pfam15914
      Location:722 → 771
      FAM193_C; FAM193 family C-terminal

    13. XM_039095999.2 → XP_038951927.1  protein FAM193B isoform X4

      UniProtKB/TrEMBL
      A0A8I6G5I0, D3ZDR1
      Conserved Domains (3) summary
      PHA03247
      Location:128 → 192
      PHA03247; large tegument protein UL36; Provisional
      cl30717
      Location:567 → 701
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
      pfam15914
      Location:722 → 771
      FAM193_C; FAM193 family C-terminal

    RNA

    1. XR_005495313.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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