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    LAMA3 laminin subunit alpha 3 [ Homo sapiens (human) ]

    Gene ID: 3909, updated on 28-Oct-2024

    Summary

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    Official Symbol
    LAMA3provided by HGNC
    Official Full Name
    laminin subunit alpha 3provided by HGNC
    Primary source
    HGNC:HGNC:6483
    See related
    Ensembl:ENSG00000053747 MIM:600805; AllianceGenome:HGNC:6483
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    E170; LOCS; BM600; JEB2A; JEB2B; JEB2C; LAMNA
    Summary
    The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014]
    Expression
    Broad expression in lung (RPKM 10.8), stomach (RPKM 10.0) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LAMA3 in Genome Data Viewer
    Location:
    18q11.2
    Exon count:
    79
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (23689453..23955066)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (23883722..24149324)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (21269417..21535030)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 29 Neighboring gene Sharpr-MPRA regulatory region 8852 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:21268776-21269325 Neighboring gene ribosomal protein S10 pseudogene 27 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:21299932-21300432 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:21300433-21300933 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:21305921-21306891 Neighboring gene ribosomal protein L23a pseudogene 77 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13164 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:21427116-21427961 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13165 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:21452354-21453553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:21531393-21532253 Neighboring gene MPRA-validated peak3071 silencer Neighboring gene long intergenic non-protein coding RNA 2958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9361 Neighboring gene TTC39C antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9363 Neighboring gene tetratricopeptide repeat domain 39C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Aberrant promoter methylation and silencing of laminin-5-encoding genes in breast carcinoma. Sathyanarayana UG, et al. Clin Cancer Res, 2003 Dec 15. PMID 14695139
    2. Association of variation in the LAMA3 gene, encoding the alpha-chain of laminin 5, with atopic dermatitis in a German case-control cohort. Stemmler S, et al. BMC Dermatol, 2014 Nov 3. PMID 25363238, Free PMC Article
    3. Lung-specific loss of α3 laminin worsens bleomycin-induced pulmonary fibrosis. Morales-Nebreda LI, et al. Am J Respir Cell Mol Biol, 2015 Apr. PMID 25188360, Free PMC Article
    4. Biological network inferences for a protection mechanism against familial Creutzfeldt-Jakob disease with E200K pathogenic mutation. Lee SM, et al. BMC Med Genomics, 2014 Aug 22. PMID 25149502, Free PMC Article
    5. A new homozygous nonsense mutation in LAMA3A underlying laryngo-onycho-cutaneous syndrome. Barzegar M, et al. Br J Dermatol, 2013 Dec. PMID 23869449

    See all (134) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [Clinical and bioinformatics analysis of the relationship between LAMA3 DNA methylation expression and platinum resistance and prognosis in epithelial ovarian cancer].
      Title: [Clinical and bioinformatics analysis of the relationship between LAMA3 DNA methylation expression and platinum resistance and prognosis in epithelial ovarian cancer].
    2. Correlation of laminin subunit alpha 3 expression in pancreatic ductal adenocarcinoma with tumor liver metastasis and survival.
      Title: Correlation of laminin subunit alpha 3 expression in pancreatic ductal adenocarcinoma with tumor liver metastasis and survival.
    3. Lentiviral expression of wild-type LAMA3A restores cell adhesion in airway basal cells from children with epidermolysis bullosa.
      Title: Lentiviral expression of wild-type LAMA3A restores cell adhesion in airway basal cells from children with epidermolysis bullosa.
    4. LAMA3 Promotes Tumorigenesis of Oral Squamous Cell Carcinoma by METTL3-Mediated N6-Methyladenosine Modification.
      Title: LAMA3 Promotes Tumorigenesis of Oral Squamous Cell Carcinoma by METTL3-Mediated N6-Methyladenosine Modification.
    5. Phenotypic variability in LAMA3-associated amelogenesis imperfecta.
      Title: Phenotypic variability in LAMA3-associated amelogenesis imperfecta.
    6. LINC00936/microRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA3.
      Title: LINC00936/microRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA3.
    7. Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five Chinese families.
      Title: Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five Chinese families.
    8. Gene expression profiling of laminin alpha3-blocked keratinocytes reveals an immune-independent mechanism of blistering.
      Title: Gene expression profiling of laminin α3-blocked keratinocytes reveals an immune-independent mechanism of blistering.
    9. High expression of LAMA3/AC245041.2 gene pair associated with KRAS mutation and poor survival in pancreatic adenocarcinoma: a comprehensive TCGA analysis.
      Title: High expression of LAMA3/AC245041.2 gene pair associated with KRAS mutation and poor survival in pancreatic adenocarcinoma: a comprehensive TCGA analysis.
    10. LAMA3 DNA methylation and transcriptome changes associated with chemotherapy resistance in ovarian cancer.
      Title: LAMA3 DNA methylation and transcriptome changes associated with chemotherapy resistance in ovarian cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (66)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
    EBI GWAS Catalog
    Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 inhibits CD3-triggered T cell co-stimulation by the extracellular matrix (ECM) proteins, which includes laminins PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 inhibits CD3-triggered T cell co-stimulation by the extracellular matrix (ECM) proteins, which includes laminins PubMed
    Tat tat Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution PubMed
    tat HIV-1 Tat enhances adhesion of human U937 monocyte-like cells to proteins of the extracellular matrix, such as collagen IV, laminin, and ECM1 PubMed
    tat HIV-1 Tat upregulates the expression of extracellular matrix proteins, including the major basement membrane protein laminin PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endodermal cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in epidermis development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in hemidesmosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basement membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in hemidesmosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of laminin-3 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of laminin-5 complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    laminin subunit alpha-3
    Names
    BM600 150kD subunit
    LAM3, alpha-3 subunit
    epiligrin 170 kda subunit
    epiligrin alpha 3 subunit
    kalinin 165kD subunit
    kalinin subunit alpha
    laminin 5, alpha-3 subunit
    laminin A3
    laminin, alpha 3 (nicein (150kD), kalinin (165kD), BM600 (150kD), epilegrin)
    laminin-5 alpha 3 chain
    laminin-5 subunit alpha
    laminin-6 subunit alpha
    laminin-7 subunit alpha
    nicein 150kD subunit
    nicein subunit alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007853.2 RefSeqGene

      Range
      4856..270469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000227.6 → NP_000218.3  laminin subunit alpha-3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_000218.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a distinct 5' UTR, lacks exons in the 5' coding region, and uses an alternate start codon compared to variant 1. The encoded isoform (2, also known as alpha3a) has a distinct and shorter N-terminus than isoform 1. Variants 2 and 4 encode "a" isoforms.
      Source sequence(s)
      AA001432, AC010754, AY327115, DA862923, KF456351, L34155
      Consensus CDS
      CCDS11880.1
      UniProtKB/TrEMBL
      A0A0A6YYF2, Q59HA6
      Related
      ENSP00000269217.5, ENST00000269217.11
      Conserved Domains (7) summary
      COG0840
      Location:399 → 779
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      cd00055
      Location:77 → 123
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:1549 → 1700
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:125 → 175
      Laminin_EGF; Laminin EGF domain
      pfam06008
      Location:236 → 495
      Laminin_I; Laminin Domain I
      pfam06009
      Location:679 → 807
      Laminin_II; Laminin Domain II
      cl21509
      Location:483 → 647
      ApoLp-III_like; Apolipophorin-III and similar insect proteins

    2. NM_001127717.4 → NP_001121189.2  laminin subunit alpha-3 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also called b2) lacks an in-frame exon in the coding region compared to variant 1. It encodes isoform 3 (also known as alpha3b2), which is shorter than isoform 1. Variants 1 and 3 encode "b" isoforms.
      Source sequence(s)
      AA001432, AC010754, AK096422, AY327116, KF456351
      Consensus CDS
      CCDS45838.1
      UniProtKB/TrEMBL
      A0A0A0MSA0, B0YJ32
      Related
      ENSP00000382432.2, ENST00000399516.7
      Conserved Domains (9) summary
      smart00136
      Location:46 → 297
      LamNT; Laminin N-terminal domain (domain VI)
      smart00281
      Location:1514 → 1641
      LamB; Laminin B domain
      smart00282
      Location:2379 → 2514
      LamG; Laminin G domain
      cd00055
      Location:535 → 577
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:3102 → 3253
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:1266 → 1314
      Laminin_EGF; Laminin EGF domain
      pfam06008
      Location:1845 → 2048
      Laminin_I; Laminin Domain I
      pfam06009
      Location:2232 → 2360
      Laminin_II; Laminin Domain II
      cl21509
      Location:2036 → 2200
      ApoLp-III_like; Apolipophorin-III and similar insect proteins

    3. NM_001127718.4 → NP_001121190.2  laminin subunit alpha-3 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001121190.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has a distinct 5' UTR, lacks exons in the 5' coding region, lacks an internal in-frame exon, and uses an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variants 2 and 4 encode "a" isoforms.
      Source sequence(s)
      AA001432, AC010754, AY327114, DA862923, KF456351
      Consensus CDS
      CCDS59307.1
      UniProtKB/TrEMBL
      A0A0A0MTS5, Q59HA6
      Related
      ENSP00000466557.1, ENST00000587184.5
      Conserved Domains (6) summary
      cd00055
      Location:77 → 123
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:1493 → 1644
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:125 → 175
      Laminin_EGF; Laminin EGF domain
      pfam06008
      Location:236 → 439
      Laminin_I; Laminin Domain I
      pfam06009
      Location:623 → 751
      Laminin_II; Laminin Domain II
      cl21509
      Location:427 → 591
      ApoLp-III_like; Apolipophorin-III and similar insect proteins

    4. NM_001302996.2 → NP_001289925.1  laminin subunit alpha-3 isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as LN1) lacks a large portion of the 3' coding region and has a distinct 3' coding region and 3' UTR compared to variant 1. The encoded isoform (5, also known as LaNt alpha31) has a distinct and shorter C-terminus than isoform 1. This variant is supported by experimental data in PMID:19773554.
      Source sequence(s)
      AC067796, AI125611, AK096422, AY327115
      UniProtKB/Swiss-Prot
      Q16787
      Conserved Domains (3) summary
      smart00136
      Location:46 → 297
      LamNT; Laminin N-terminal domain (domain VI)
      cd00055
      Location:299 → 344
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:356 → 423
      Laminin_EGF; Laminin EGF domain

    5. NM_198129.4 → NP_937762.2  laminin subunit alpha-3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_937762.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as b1, represents the longest transcript and encodes the longest isoform (1, also known as alpha3B1). Variants 1 and 3 encode "b" isoforms.
      Source sequence(s)
      AB107369, AC010754, AC067796
      Consensus CDS
      CCDS42419.1
      UniProtKB/Swiss-Prot
      B0YJ33, Q13679, Q13680, Q16787, Q6VU67, Q6VU68, Q6VU69, Q76E14, Q96TG0
      UniProtKB/TrEMBL
      B0YJ32
      Related
      ENSP00000324532.8, ENST00000313654.14
      Conserved Domains (9) summary
      smart00136
      Location:46 → 297
      LamNT; Laminin N-terminal domain (domain VI)
      smart00281
      Location:1514 → 1641
      LamB; Laminin B domain
      smart00282
      Location:2435 → 2570
      LamG; Laminin G domain
      cd00055
      Location:535 → 577
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:3158 → 3309
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:1266 → 1314
      Laminin_EGF; Laminin EGF domain
      pfam06008
      Location:1845 → 2104
      Laminin_I; Laminin Domain I
      pfam06009
      Location:2288 → 2416
      Laminin_II; Laminin Domain II
      cl21509
      Location:2092 → 2256
      ApoLp-III_like; Apolipophorin-III and similar insect proteins

    RNA

    1. NR_130106.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks multiple 3' exons and uses an alternate 3' terminal exon compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translation start codon results in an open reading frame without a stop codon and renders the transcript a candidate for non-stop decay.
      Source sequence(s)
      AK096422, BC033663, BC093406
      Related
      ENST00000585600.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      23689453..23955066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525978.3 → XP_011524280.1  laminin subunit alpha-3 isoform X1

      UniProtKB/TrEMBL
      B0YJ32
      Conserved Domains (9) summary
      smart00136
      Location:46 → 297
      LamNT; Laminin N-terminal domain (domain VI)
      smart00281
      Location:1523 → 1650
      LamB; Laminin B domain
      smart00282
      Location:2444 → 2579
      LamG; Laminin G domain
      cd00055
      Location:535 → 577
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:3167 → 3318
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:1275 → 1323
      Laminin_EGF; Laminin EGF domain
      pfam06008
      Location:1854 → 2113
      Laminin_I; Laminin Domain I
      pfam06009
      Location:2297 → 2425
      Laminin_II; Laminin Domain II
      cl21509
      Location:2101 → 2265
      ApoLp-III_like; Apolipophorin-III and similar insect proteins

    2. XM_011525982.3 → XP_011524284.1  laminin subunit alpha-3 isoform X8

      UniProtKB/TrEMBL
      B0YJ32
      Conserved Domains (9) summary
      smart00136
      Location:46 → 297
      LamNT; Laminin N-terminal domain (domain VI)
      smart00281
      Location:1523 → 1650
      LamB; Laminin B domain
      smart00282
      Location:2345 → 2480
      LamG; Laminin G domain
      cd00055
      Location:535 → 577
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:3068 → 3219
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:1275 → 1323
      Laminin_EGF; Laminin EGF domain
      pfam06008
      Location:1854 → 2113
      Laminin_I; Laminin Domain I
      pfam06009
      Location:2217 → 2326
      Laminin_II; Laminin Domain II
      cl21509
      Location:2066 → 2196
      ApoLp-III_like; Apolipophorin-III and similar insect proteins

    3. XM_011525980.3 → XP_011524282.1  laminin subunit alpha-3 isoform X3

      UniProtKB/TrEMBL
      B0YJ32
      Conserved Domains (9) summary
      smart00136
      Location:46 → 297
      LamNT; Laminin N-terminal domain (domain VI)
      smart00281
      Location:1517 → 1644
      LamB; Laminin B domain
      smart00282
      Location:2438 → 2573
      LamG; Laminin G domain
      cd00055
      Location:535 → 577
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:3161 → 3312
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:1269 → 1317
      Laminin_EGF; Laminin EGF domain
      pfam06008
      Location:1848 → 2107
      Laminin_I; Laminin Domain I
      pfam06009
      Location:2291 → 2419
      Laminin_II; Laminin Domain II
      cl21509
      Location:2095 → 2259
      ApoLp-III_like; Apolipophorin-III and similar insect proteins

    4. XM_011525979.3 → XP_011524281.1  laminin subunit alpha-3 isoform X2

      UniProtKB/TrEMBL
      B0YJ32
      Conserved Domains (9) summary
      smart00136
      Location:46 → 297
      LamNT; Laminin N-terminal domain (domain VI)
      smart00281
      Location:1520 → 1647
      LamB; Laminin B domain
      smart00282
      Location:2441 → 2576
      LamG; Laminin G domain
      cd00055
      Location:535 → 577
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:3164 → 3315
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:1272 → 1320
      Laminin_EGF; Laminin EGF domain
      pfam06008
      Location:1851 → 2110
      Laminin_I; Laminin Domain I
      pfam06009
      Location:2294 → 2422
      Laminin_II; Laminin Domain II
      cl21509
      Location:2098 → 2262
      ApoLp-III_like; Apolipophorin-III and similar insect proteins

    5. XM_047437506.1 → XP_047293462.1  laminin subunit alpha-3 isoform X9

    6. XM_011525981.3 → XP_011524283.1  laminin subunit alpha-3 isoform X4

      UniProtKB/TrEMBL
      B0YJ32
      Conserved Domains (9) summary
      smart00136
      Location:46 → 297
      LamNT; Laminin N-terminal domain (domain VI)
      smart00281
      Location:1479 → 1606
      LamB; Laminin B domain
      smart00282
      Location:2400 → 2535
      LamG; Laminin G domain
      cd00055
      Location:491 → 533
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:3123 → 3274
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:1231 → 1279
      Laminin_EGF; Laminin EGF domain
      pfam06008
      Location:1810 → 2069
      Laminin_I; Laminin Domain I
      pfam06009
      Location:2253 → 2381
      Laminin_II; Laminin Domain II
      cl21509
      Location:2057 → 2221
      ApoLp-III_like; Apolipophorin-III and similar insect proteins

    7. XM_047437503.1 → XP_047293459.1  laminin subunit alpha-3 isoform X5

    8. XM_047437504.1 → XP_047293460.1  laminin subunit alpha-3 isoform X6

    9. XM_047437505.1 → XP_047293461.1  laminin subunit alpha-3 isoform X7

    10. XM_017025743.1 → XP_016881232.1  laminin subunit alpha-3 isoform X10

      UniProtKB/TrEMBL
      A0A3B3ITG1
      Related
      ENSP00000497885.1, ENST00000649721.1

    11. XM_017025744.2 → XP_016881233.1  laminin subunit alpha-3 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      23883722..24149324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318609.1 → XP_054174584.1  laminin subunit alpha-3 isoform X1

    2. XM_054318616.1 → XP_054174591.1  laminin subunit alpha-3 isoform X8

    3. XM_054318611.1 → XP_054174586.1  laminin subunit alpha-3 isoform X3

    4. XM_054318610.1 → XP_054174585.1  laminin subunit alpha-3 isoform X2

    5. XM_054318617.1 → XP_054174592.1  laminin subunit alpha-3 isoform X9

    6. XM_054318612.1 → XP_054174587.1  laminin subunit alpha-3 isoform X4

    7. XM_054318613.1 → XP_054174588.1  laminin subunit alpha-3 isoform X5

    8. XM_054318614.1 → XP_054174589.1  laminin subunit alpha-3 isoform X6

    9. XM_054318615.1 → XP_054174590.1  laminin subunit alpha-3 isoform X7

    10. XM_054318618.1 → XP_054174593.1  laminin subunit alpha-3 isoform X10

    11. XM_054318619.1 → XP_054174594.1  laminin subunit alpha-3 isoform X11

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16787.3 GenPept UniProtKB/Swiss-Prot:Q16787

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