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    NEK2 NIMA related kinase 2 [ Homo sapiens (human) ]

    Gene ID: 4751, updated on 2-Nov-2024

    Summary

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    Official Symbol
    NEK2provided by HGNC
    Official Full Name
    NIMA related kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:7745
    See related
    Ensembl:ENSG00000117650 MIM:604043; AllianceGenome:HGNC:7745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NLK1; RP67; NEK2A; HsPK21; PPP1R111
    Summary
    This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011]
    Expression
    Biased expression in testis (RPKM 28.1), bone marrow (RPKM 3.8) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NEK2 in Genome Data Viewer
    Location:
    1q32.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (211658256..211675621, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (210904362..210921749, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (211831598..211848963, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372903 Neighboring gene Sharpr-MPRA regulatory region 10274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:211794336-211794836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:211805695-211806270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:211815933-211816768 Neighboring gene Sharpr-MPRA regulatory region 10021 Neighboring gene non-coding transcript regulating alternative splicing Neighboring gene farnesyl diphosphate synthase pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2489 Neighboring gene Sharpr-MPRA regulatory region 55 Neighboring gene NEK2 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:211868601-211869100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1791 Neighboring gene NANOG hESC enhancer GRCh37_chr1:211877490-211877991 Neighboring gene uncharacterized LOC105372904

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Integrative Bioinformatics Analysis Identifies NEK2 as a Potential Biomarker in Head and Neck Squamous Cell Carcinoma. Liu S, et al. J Comput Biol, 2020 Jan. PMID 31460782
    2. Nek2 as a novel molecular target for the treatment of breast carcinoma. Tsunoda N, et al. Cancer Sci, 2009 Jan. PMID 19038001, Free PMC Article
    3. NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma. Hao M, et al. Leukemia, 2017 Jul. PMID 28400617, Free PMC Article
    4. Effect of NIMA-related kinase 2B on the sensitivity of breast cancer to paclitaxel in vitro and vivo. Wang Y, et al. Tumour Biol, 2017 May. PMID 28475000
    5. Clinical significance and prognostic value of Nek2 protein expression in colon cancer. Lu L, et al. Int J Clin Exp Pathol, 2015. PMID 26823916, Free PMC Article

    See all (202) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Function of NEK2 in clear cell renal cell carcinoma and its effect on the tumor microenvironment.
      Title: Function of NEK2 in clear cell renal cell carcinoma and its effect on the tumor microenvironment.
    2. NEK2 promotes TP53 ubiquitination to enhance the proliferation and migration of TP53 wild-type glioblastoma cells.
      Title: NEK2 promotes TP53 ubiquitination to enhance the proliferation and migration of TP53 wild-type glioblastoma cells.
    3. Abnormal methylation mediated upregulation of LINC00857 boosts malignant progression of lung adenocarcinoma by modulating the miR-486-5p/NEK2 axis.
      Title: Abnormal methylation mediated upregulation of LINC00857 boosts malignant progression of lung adenocarcinoma by modulating the miR-486-5p/NEK2 axis.
    4. NEK2 promotes the development of ovarian endometriosis and impairs decidualization by phosphorylating FOXO1.
      Title: NEK2 promotes the development of ovarian endometriosis and impairs decidualization by phosphorylating FOXO1.
    5. [Expression and clinical significance of NEK2 and EMT related molecules in oral squamous cell carcinoma].
      Title: [Expression and clinical significance of NEK2 and EMT related molecules in oral squamous cell carcinoma].
    6. Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction.
      Title: Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction.
    7. Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers.
      Title: Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers.
    8. Molecular characteristics, oncogenic roles, and relevant immune and pharmacogenomic features of NEK2 in gastric cancer.
      Title: Molecular characteristics, oncogenic roles, and relevant immune and pharmacogenomic features of NEK2 in gastric cancer.
    9. NEK2 is associated with poor prognosis of clear cell renal cell carcinoma and promotes tumor cell growth and metastasis.
      Title: NEK2 is associated with poor prognosis of clear cell renal cell carcinoma and promotes tumor cell growth and metastasis.
    10. NEK2 inactivates the Hippo pathway to advance the proliferation of cervical cancer cells by cooperating with STRIPAK complexes.
      Title: NEK2 inactivates the Hippo pathway to advance the proliferation of cervical cancer cells by cooperating with STRIPAK complexes.
    Submit: New GeneRIF Correction See all GeneRIFs (128)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Retinitis pigmentosa 67
    MedGen: C3809954 OMIM: 615565 GeneReviews: Not available
    		not available

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with NEK2 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blastocyst development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome separation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of centriole-centriole cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic centrosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic centrosome separation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic nuclear division TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in spindle assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed nuclear chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    colocalizes_with kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek2
    Names
    NIMA (never in mitosis gene a)-related kinase 2
    nimA-like protein kinase 1
    nimA-related protein kinase 2
    protein phosphatase 1, regulatory subunit 111
    NP_001191111.1
    NP_001191112.1
    NP_002488.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029112.1 RefSeqGene

      Range
      5010..17859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001204182.2 → NP_001191111.1  serine/threonine-protein kinase Nek2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK225522, BT019729, DC407297
      Consensus CDS
      CCDS73024.1
      UniProtKB/TrEMBL
      B4DZU0, F6U4U2
      Related
      ENSP00000440237.2, ENST00000540251.5
      Conserved Domains (2) summary
      smart00220
      Location:8 → 271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08217
      Location:7 → 271
      STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2

    2. NM_001204183.2 → NP_001191112.1  serine/threonine-protein kinase Nek2 isoform 2

      See identical proteins and their annotated locations for NP_001191112.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs at the 3' end compared to variant 1. This results in a frame-shift and a shorter isoform (2, also known as NEK2B) with a distinct C-terminus compared to isoform 1. Isoforms 1 and 2 have been reported to exhibit distinct pattern of expression during mitosis (PMID:11742531).
      Source sequence(s)
      AC096637, AY045701, BT019729, BU517064, DC407297
      Consensus CDS
      CCDS55682.1
      UniProtKB/TrEMBL
      B4DZU0
      Related
      ENSP00000355965.3, ENST00000366998.4
      Conserved Domains (2) summary
      smart00220
      Location:8 → 271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08217
      Location:7 → 271
      STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2

    3. NM_002497.4 → NP_002488.1  serine/threonine-protein kinase Nek2 isoform 1

      See identical proteins and their annotated locations for NP_002488.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longest isoform (1, also known as NEK2A). The C-terminus (aa 399-445) of this isoform was shown to be responsible for its nucleolar localization (PMID:15161910). Isoforms 1 and 2 (which differ at the C-terminus) have also been reported to exhibit distinct pattern of expression during mitosis (PMID:11742531).
      Source sequence(s)
      AK223353, BC043502, BT019729, DC407297
      Consensus CDS
      CCDS1500.1
      UniProtKB/Swiss-Prot
      P51955, Q53FD6, Q5I1Z9, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9
      UniProtKB/TrEMBL
      B4DZU0
      Related
      ENSP00000355966.4, ENST00000366999.9
      Conserved Domains (1) summary
      cd08217
      Location:7 → 271
      STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      211658256..211675621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      210904362..210921749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51955.1 GenPept UniProtKB/Swiss-Prot:P51955

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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