Eif4ebp3 eukaryotic translation initiation factor 4E binding protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif4ebp3provided by MGI
Official Full Name: eukaryotic translation initiation factor 4E binding protein 3provided by MGI
Primary source: MGI:MGI:1270847
See related: Ensembl:ENSMUSG00000090264 AllianceGenome:MGI:1270847
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4e-bp3
Summary: Predicted to enable eukaryotic initiation factor 4E binding activity. Predicted to be involved in negative regulation of translational initiation. Predicted to act upstream of or within negative regulation of translation. Predicted to be active in cytoplasm. Is expressed in gut; male reproductive gland or organ; and metanephros. Orthologous to human EIF4EBP3 (eukaryotic translation initiation factor 4E binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 90.8), liver E18 (RPKM 18.7) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B2; 18 19.46 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (36797113..36799377)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (36664060..36666324)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

there are overlapping reading frames in the mouse and human genes for 4E-BP3 and MASK
Title: Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

General gene information

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Readthrough Maskbp3

Readthrough gene: Maskbp3, Included gene: Ankhd1

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables eukaryotic initiation factor 4E binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translational initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 4E-binding protein 3

Names: eIF4E-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.