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    STOML1 stomatin like 1 [ Homo sapiens (human) ]

    Gene ID: 9399, updated on 14-Nov-2024

    Summary

    Official Symbol
    STOML1provided by HGNC
    Official Full Name
    stomatin like 1provided by HGNC
    Primary source
    HGNC:HGNC:14560
    See related
    Ensembl:ENSG00000067221 MIM:608326; AllianceGenome:HGNC:14560
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLP-1; STORP; hUNC-24
    Summary
    Predicted to enable ion channel inhibitor activity. Predicted to be involved in lipid transport. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cytoplasmic vesicle. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 7.6), thyroid (RPKM 3.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See STOML1 in Genome Data Viewer
    Location:
    15q24.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (73978926..73994622, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (71796271..71811967, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (74271267..74286963, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74173695-74174256 Neighboring gene TBC1 domain family member 21 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:74179454-74179712 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74194653-74195154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74214297-74215284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74215285-74216270 Neighboring gene LOXL1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74219309-74220142 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74220143-74220976 Neighboring gene Sharpr-MPRA regulatory region 13651 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74229856-74230455 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74232882-74233777 Neighboring gene lysyl oxidase like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74244872-74245555 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:74249081-74250280 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9732 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:74280304-74281503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9737 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6644 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9738 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74289929-74290431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9739 Neighboring gene PML nuclear body scaffold Neighboring gene ReSE screen-validated silencer GRCh37_chr15:74311530-74311700 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74329432-74330313 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:74333577-74334149 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:74338704-74338895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:74357879-74358380 Neighboring gene dynamin 1 pseudogene 33

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    General gene information

    Clone Names

    • FLJ36370

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in lipid transport  
    Component Evidence Code Pubs
    located_in late endosome membrane  
    located_in membrane raft  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    stomatin-like protein 1
    Names
    EPB72-like 1
    EPB72-like protein 1
    protein unc-24 homolog
    stomatin (EBP72)-like 1
    stomatin (EPB72)-like 1
    stomatin-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256672.2NP_001243601.1  stomatin-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001243601.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC108137, AF156557, AK222665, AK302051, AL109665
      UniProtKB/TrEMBL
      Q53HB6
      Conserved Domains (3) summary
      smart00244
      Location:77217
      PHB; prohibitin homologues
      cd13436
      Location:94224
      SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      pfam02036
      Location:303394
      SCP2; SCP-2 sterol transfer family
    2. NM_001256673.1NP_001243602.1  stomatin-like protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001243602.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AF156557, AK302051
      Consensus CDS
      CCDS58384.1
      UniProtKB/TrEMBL
      Q53HB6
      Related
      ENSP00000319384.6, ENST00000316911.10
      Conserved Domains (3) summary
      smart00244
      Location:83167
      PHB; prohibitin homologues
      pfam02036
      Location:254345
      SCP2; SCP-2 sterol transfer family
      cl19107
      Location:79174
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    3. NM_001256674.2NP_001243603.1  stomatin-like protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC108137, AF156557, AK302051, AL109664
      Consensus CDS
      CCDS58383.1
      UniProtKB/TrEMBL
      Q53HB6
      Related
      ENSP00000456343.1, ENST00000564777.5
      Conserved Domains (3) summary
      smart00244
      Location:83167
      PHB; prohibitin homologues
      pfam02036
      Location:253344
      SCP2; SCP-2 sterol transfer family
      cl19107
      Location:79174
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    4. NM_001256675.2NP_001243604.1  stomatin-like protein 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AC108137, AF156557, AK302051, DQ064605
      Consensus CDS
      CCDS58385.1
      UniProtKB/TrEMBL
      Q53HB6
      Related
      ENSP00000352788.4, ENST00000359750.8
      Conserved Domains (3) summary
      smart00244
      Location:77217
      PHB; prohibitin homologues
      cd13436
      Location:94224
      SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      pfam02036
      Location:264324
      SCP2; SCP-2 sterol transfer family
    5. NM_001256676.1NP_001243605.1  stomatin-like protein 1 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, initiates translation at a downstream, in-frame start codon and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.
      Source sequence(s)
      AK302051, AL109665, AL533460, BX464941
      Consensus CDS
      CCDS58381.1
      UniProtKB/TrEMBL
      H3BST3
      Related
      ENSP00000456853.1, ENST00000561656.5
      Conserved Domains (4) summary
      smart00244
      Location:1130
      PHB; prohibitin homologues
      cd13436
      Location:7137
      SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      pfam02036
      Location:216307
      SCP2; SCP-2 sterol transfer family
      cl21455
      Location:179251
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    6. NM_001256677.1NP_001243606.1  stomatin-like protein 1 isoform 7

      See identical proteins and their annotated locations for NP_001243606.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) contains an alternate exon in the 5' region, initiates translation at an alternate start codon and uses an alternate in-frame splice site in the coding region, compared to variant 1. the encoded isoform (7) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AF156557, AK300799, AK302051, AL109665
      Consensus CDS
      CCDS58382.1
      UniProtKB/TrEMBL
      Q53HB6
      Related
      ENSP00000319323.6, ENST00000316900.9
      Conserved Domains (4) summary
      smart00244
      Location:35175
      PHB; prohibitin homologues
      cd13436
      Location:52182
      SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      pfam02036
      Location:261352
      SCP2; SCP-2 sterol transfer family
      cl21455
      Location:224296
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    7. NM_001324226.1NP_001311155.1  stomatin-like protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC108137
      Conserved Domains (3) summary
      pfam02036
      Location:147238
      SCP2; SCP-2 sterol transfer family
      cl19107
      Location:168
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      cl21455
      Location:110182
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    8. NM_001324227.1NP_001311156.1  stomatin-like protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC108137
      Conserved Domains (4) summary
      smart00244
      Location:1130
      PHB; prohibitin homologues
      cd13436
      Location:7137
      SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      pfam02036
      Location:217308
      SCP2; SCP-2 sterol transfer family
      cl21455
      Location:180252
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    9. NM_001324228.2NP_001311157.1  stomatin-like protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC108137
      Conserved Domains (4) summary
      smart00244
      Location:1130
      PHB; prohibitin homologues
      cd13436
      Location:7137
      SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      pfam02036
      Location:217308
      SCP2; SCP-2 sterol transfer family
      cl21455
      Location:180252
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    10. NM_001324229.2NP_001311158.1  stomatin-like protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC108137
      Conserved Domains (2) summary
      pfam02036
      Location:148239
      SCP2; SCP-2 sterol transfer family
      cl19107
      Location:168
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    11. NM_001324230.2NP_001311159.1  stomatin-like protein 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC108137
      UniProtKB/TrEMBL
      Q53HB6
      Conserved Domains (4) summary
      smart00244
      Location:35175
      PHB; prohibitin homologues
      cd13436
      Location:52182
      SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      pfam02036
      Location:262353
      SCP2; SCP-2 sterol transfer family
      cl21455
      Location:225297
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    12. NM_004809.5NP_004800.2  stomatin-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_004800.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC108137, AF156557, AK302051
      Consensus CDS
      CCDS10254.1
      UniProtKB/Swiss-Prot
      B3KQN0, B4DUU5, B4DXM9, E7ESC0, H3BRP3, O95675, Q4PNR4, Q6FGL8, Q8WYI7, Q9UBI4, Q9UMB9, Q9UMC0, Q9Y6H9
      UniProtKB/TrEMBL
      Q53HB6
      Related
      ENSP00000442478.2, ENST00000541638.6
      Conserved Domains (3) summary
      smart00244
      Location:77217
      PHB; prohibitin homologues
      cd13436
      Location:94224
      SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      pfam02036
      Location:304395
      SCP2; SCP-2 sterol transfer family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      73978926..73994622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      71796271..71811967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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