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    ITGB7 integrin subunit beta 7 [ Homo sapiens (human) ]

    Gene ID: 3695, updated on 28-Oct-2024

    Summary

    Official Symbol
    ITGB7provided by HGNC
    Official Full Name
    integrin subunit beta 7provided by HGNC
    Primary source
    HGNC:HGNC:6162
    See related
    Ensembl:ENSG00000139626 MIM:147559; AllianceGenome:HGNC:6162
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
    Expression
    Broad expression in spleen (RPKM 15.4), lymph node (RPKM 15.4) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ITGB7 in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (53191323..53207251, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (53156921..53172850, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53585107..53601035, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53552337-53552837 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53553211-53553838 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:53559172-53559335 Neighboring gene cysteine sulfinic acid decarboxylase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53565297-53565796 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr12:53568663-53569598 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:53573975-53574533 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4496 Neighboring gene Sharpr-MPRA regulatory region 11900 Neighboring gene zinc finger protein 740 Neighboring gene Sharpr-MPRA regulatory region 11320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53609063-53609836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53610051-53610664 Neighboring gene Sharpr-MPRA regulatory region 13987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4497 Neighboring gene retinoic acid receptor gamma Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4498 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4499 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4500 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4501 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53635595-53636507 Neighboring gene uncharacterized LOC122455340

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infected patients exhibit an upregulation of ITGA4/ITGB7 positive lymphocytes in peripheral blood of immunological nonresponder clinical samples PubMed
    Knockdown of integrin, beta 7 (ITGB7) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 Env (gp120) V2/V3 loops bind to ITGA4 and ITGB7 (a4b7), which can be inhibited by anti-V2 peptide or integrin or anti-V3 antibodies PubMed
    env HIV-1 Env gp120 amino acids from position 158 to 192 bind alpha-4/beta-7 integrin (ITGA4/ITGB7) PubMed
    env HIV-1 Env gp120 with P/SDI/V-ITGA4/ITGB7 binding motifs interact more with ITGA4/ITGB7 PubMed
    env HIV-1 Env gp120/41 (JRFL Env in the contaxt of HIV-Gag-GFP VLP) binds to ITGB7 on the surface of basophils PubMed
    env Increased integrin alpha4beta7 affinity is mediated by sequences encoded in gp120 V1/V2 and also influenced by N-linked glycosylation sites located in gp120 C3/V4 PubMed
    env Little or no integrin alpha4beta7 binding is detected with multiple HIV-1 gp120s and gp140s, including gp120s from transmitted/founder strains, or when gp120 is produced in CHO, 293T, and 293S/GnT1(-/-) cells PubMed
    env The peptide segment at positions 166-178 of the V2 loop of HIV-1 gp120 appears to harbor a cryptic determinant of integrin alpha4beta7 binding on primary human T cells PubMed
    env Integrin alpha4beta 7 mediates HIV-1 gp120 binding to natural killer cells. The residues 182-184 in the V2 loop of gp120 is required for the binding between gp120 and integrin alpha4beta7 PubMed
    env Treatment of B cells with HIV-1 gp120 upregulates the expression of FCRL4 and limits the proliferative expansion of B cells in an integrin alpha 4/beta 7-dependent manner PubMed
    env HIV-1 gp120 binds to human B cells through integrin alpha 4/beta 7 PubMed
    env HIV-1 gp120/41 Envelope proteins form a complex with integrin alpha4beta7 and chemokine receptor CCR5 on the CD4-negative gamma-delta T cell membrane, which leads to activation of the p38-caspase pathway and induces the death of gamma-delta cells PubMed
    env The gp120-integrin alpha4beta7 complex mediates LFA-1 activation on T cells and increases the efficiency of infection by promoting synapse formation PubMed
    Envelope surface glycoprotein gp160, precursor env Little or no integrin alpha4beta7 binding is detected with multiple HIV-1140s in human cells PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp120/41 Envelope proteins form a complex with integrin alpha4beta7 and chemokine receptor CCR5 on the CD4-negative gamma-delta T cell membrane, which leads to activation of the p38-caspase pathway and induces the death of gamma-delta cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in T cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell-matrix adhesion involved in ameboidal cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heterotypic cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immune response in gut-associated lymphoid tissue NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in leukocyte migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in leukocyte tethering or rolling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in receptor clustering IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of integrin alpha4-beta7 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of integrin alpha4-beta7 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane HDA PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    integrin beta-7
    Names
    gut homing receptor beta subunit
    integrin beta 7 subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000889.3NP_000880.1  integrin beta-7 isoform a precursor

      See identical proteins and their annotated locations for NP_000880.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 3-8 all encode the same isoform (a).
      Source sequence(s)
      DC296007, S80335
      Consensus CDS
      CCDS8849.1
      UniProtKB/Swiss-Prot
      P26010, Q9UCP7, Q9UCS7
      Related
      ENSP00000267082.4, ENST00000267082.10
      Conserved Domains (5) summary
      smart00187
      Location:50476
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:645717
      Integrin_B_tail; Integrin beta tail domain
      pfam07974
      Location:607635
      EGF_2; EGF-like domain
      pfam08725
      Location:750791
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      pfam12785
      Location:537645
      VESA1_N; Variant erythrocyte surface antigen-1
    2. NM_001414156.1NP_001401085.1  integrin beta-7 isoform a precursor

      Status: REVIEWED

      Source sequence(s)
      AC073573
      UniProtKB/Swiss-Prot
      P26010, Q9UCP7, Q9UCS7
    3. NM_001414157.1NP_001401086.1  integrin beta-7 isoform a precursor

      Status: REVIEWED

      Source sequence(s)
      AC073573
      UniProtKB/Swiss-Prot
      P26010, Q9UCP7, Q9UCS7
    4. NM_001414158.1NP_001401087.1  integrin beta-7 isoform a precursor

      Status: REVIEWED

      Source sequence(s)
      AC073573
      UniProtKB/Swiss-Prot
      P26010, Q9UCP7, Q9UCS7
      Related
      ENSP00000408741.3, ENST00000422257.7
    5. NM_001414159.1NP_001401088.1  integrin beta-7 isoform a precursor

      Status: REVIEWED

      Source sequence(s)
      AC073573
      UniProtKB/Swiss-Prot
      P26010, Q9UCP7, Q9UCS7
    6. NM_001414160.1NP_001401089.1  integrin beta-7 isoform a precursor

      Status: REVIEWED

      Source sequence(s)
      AC073573
      UniProtKB/Swiss-Prot
      P26010, Q9UCP7, Q9UCS7
    7. NM_001414161.1NP_001401090.1  integrin beta-7 isoform a precursor

      Status: REVIEWED

      Source sequence(s)
      AC073573
      UniProtKB/Swiss-Prot
      P26010, Q9UCP7, Q9UCS7
    8. NM_001414162.1NP_001401091.1  integrin beta-7 isoform b precursor

      Status: REVIEWED

      Source sequence(s)
      AC073573
    9. NM_001414163.1NP_001401092.1  integrin beta-7 isoform b precursor

      Status: REVIEWED

      Source sequence(s)
      AC073573
    10. NM_001414164.1NP_001401093.1  integrin beta-7 isoform b precursor

      Status: REVIEWED

      Source sequence(s)
      AC073573
    11. NM_001414165.1NP_001401094.1  integrin beta-7 isoform c precursor

      Status: REVIEWED

      Source sequence(s)
      AC073573
    12. NM_001414166.1NP_001401095.1  integrin beta-7 isoform c precursor

      Status: REVIEWED

      Source sequence(s)
      AC073573
    13. NM_001414167.1NP_001401096.1  integrin beta-7 isoform c precursor

      Status: REVIEWED

      Source sequence(s)
      AC073573
    14. NM_001414169.1NP_001401098.1  integrin beta-7 isoform d precursor

      Status: REVIEWED

      Source sequence(s)
      AC073573
    15. NM_001414170.1NP_001401099.1  integrin beta-7 isoform d precursor

      Status: REVIEWED

      Source sequence(s)
      AC073573
    16. NM_001414171.1NP_001401100.1  integrin beta-7 isoform d precursor

      Status: REVIEWED

      Source sequence(s)
      AC073573
    17. NM_001414172.1NP_001401101.1  integrin beta-7 isoform d precursor

      Status: REVIEWED

      Source sequence(s)
      AC073573
      Related
      ENSP00000455374.2, ENST00000550743.6
    18. NM_001414173.1NP_001401102.1  integrin beta-7 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC073573

    RNA

    1. NR_104181.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks one alternate 5' exon and three alternate 3' exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC073573, AI804573, AK300960
      Related
      ENST00000542497.5
    2. NR_182253.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC073573
    3. NR_182254.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC073573

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      53191323..53207251 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      53156921..53172850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)