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    CMTM5 CKLF like MARVEL transmembrane domain containing 5 [ Homo sapiens (human) ]

    Gene ID: 116173, updated on 2-Nov-2024

    Summary

    Official Symbol
    CMTM5provided by HGNC
    Official Full Name
    CKLF like MARVEL transmembrane domain containing 5provided by HGNC
    Primary source
    HGNC:HGNC:19176
    See related
    Ensembl:ENSG00000166091 MIM:607888; AllianceGenome:HGNC:19176
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CKLFSF5
    Summary
    This gene encodes a member of the chemokine-like factor superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. The encoded protein may exhibit tumor suppressor activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
    Expression
    Biased expression in brain (RPKM 15.6), bone marrow (RPKM 1.3) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CMTM5 in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (23376771..23379772)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (17577688..17580788)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23846255..23848981)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23832478-23832978 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23832979-23833479 Neighboring gene embryonal Fyn-associated substrate Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8171 Neighboring gene interleukin 25 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:23854904-23856103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23858153-23858756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23858757-23859360 Neighboring gene myosin heavy chain 6 Neighboring gene microRNA 208a Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23871133-23871675 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23871676-23872217 Neighboring gene VISTA enhancer hs2155 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:23884455-23885654 Neighboring gene myosin heavy chain 7 Neighboring gene myosin heavy chain associated RNA transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • FLJ37521

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in chemotaxis  
    involved_in negative regulation of myoblast differentiation  
    involved_in signal transduction  
    Component Evidence Code Pubs
    located_in extracellular space  
    is_active_in membrane  

    General protein information

    Preferred Names
    CKLF-like MARVEL transmembrane domain-containing protein 5
    Names
    chemokine-like factor super family 5
    chemokine-like factor superfamily member 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037288.2NP_001032365.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform c

      See identical proteins and their annotated locations for NP_001032365.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
      Source sequence(s)
      AF479262, AY820135, BC013109
      Consensus CDS
      CCDS32050.1
      UniProtKB/Swiss-Prot
      Q96DZ9
      Related
      ENSP00000372259.2, ENST00000382809.2
      Conserved Domains (1) summary
      cl04571
      Location:29105
      MARVEL; Membrane-associating domain
    2. NM_001288744.2NP_001275673.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform d

      See identical proteins and their annotated locations for NP_001275673.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (d) is shorter, compared to isoform a.
      Source sequence(s)
      AF527949
      Consensus CDS
      CCDS73618.1
      UniProtKB/TrEMBL
      C9JAI6
      Related
      ENSP00000380404.3, ENST00000397227.7
    3. NM_001288745.2NP_001275674.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform e

      See identical proteins and their annotated locations for NP_001275674.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.
      Source sequence(s)
      AF527948
      Consensus CDS
      CCDS73619.1
      UniProtKB/Swiss-Prot
      Q96DZ9
      Related
      ENSP00000344160.4, ENST00000342473.8
    4. NM_001288746.2NP_001275675.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform f

      See identical proteins and their annotated locations for NP_001275675.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) includes an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (f) is longer, compared to isoform a.
      Source sequence(s)
      AF527413
      Consensus CDS
      CCDS73617.1
      UniProtKB/Swiss-Prot
      E9PH91, Q5PY48, Q96DZ9
      Related
      ENSP00000344819.4, ENST00000339180.9
      Conserved Domains (1) summary
      pfam01284
      Location:29152
      MARVEL; Membrane-associating domain
    5. NM_138460.3NP_612469.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform a

      See identical proteins and their annotated locations for NP_612469.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AL049829
      Consensus CDS
      CCDS9598.1
      UniProtKB/Swiss-Prot
      Q96DZ9
      Related
      ENSP00000352270.3, ENST00000359320.7
      Conserved Domains (1) summary
      pfam01284
      Location:29139
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      23376771..23379772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430907.1XP_047286863.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform X1

    2. XM_047430906.1XP_047286862.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform X1

      Related
      ENSP00000497215.1, ENST00000649278.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      17577688..17580788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375326.1XP_054231301.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform X1

    2. XM_054375327.1XP_054231302.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform X1

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