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    SPDYA speedy/RINGO cell cycle regulator family member A [ Homo sapiens (human) ]

    Gene ID: 245711, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SPDYAprovided by HGNC
    Official Full Name
    speedy/RINGO cell cycle regulator family member Aprovided by HGNC
    Primary source
    HGNC:HGNC:30613
    See related
    Ensembl:ENSG00000163806 MIM:614029; AllianceGenome:HGNC:30613
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPY1; SPDY1; RINGO3; RINGOA
    Summary
    Enables protein kinase activator activity and protein kinase binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of cell population proliferation; and positive regulation of protein kinase activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis (RPKM 22.5), duodenum (RPKM 1.7) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SPDYA in Genome Data Viewer
    Location:
    2p23.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (28810834..28850610)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (28854444..28894219)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (29033700..29073476)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100505774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:28945848-28946348 Neighboring gene MPRA-validated peak3641 silencer Neighboring gene PPP1CB divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11311 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:28974622-28975266 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:28978040-28978253 Neighboring gene protein phosphatase 1 catalytic subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11314 Neighboring gene tRNA methyltransferase 61B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:29091169-29091684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:29091685-29092199 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:29092829-29093353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15527 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:29105260-29105423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11315 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:29117677-29118300 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:29118301-29118922 Neighboring gene WD repeat domain 43 Neighboring gene small nucleolar RNA, C/D box 92 Neighboring gene small nucleolar RNA, C/D box 53

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Salicylidene acylhydrazides attenuate survival of SH-SY5Y neuroblastoma cells through affecting mitotic regulator Speedy/RINGO and ERK/MAPK-PI3K/AKT signaling. Arziman S, et al. Med Oncol, 2020 Jul 20. PMID 32691165
    2. Expression and prognostic role of Spy1 as a novel cell cycle protein in hepatocellular carcinoma. Ke Q, et al. Exp Mol Pathol, 2009 Dec. PMID 19686732
    3. Spy1 is frequently overexpressed in malignant gliomas and critically regulates the proliferation of glioma cells. Zhang L, et al. J Mol Neurosci, 2012 Jul. PMID 22447439
    4. Cell adhesion to fibronectin down-regulates the expression of Spy1 and contributes to drug resistance in multiple myeloma cells. Fei M, et al. Int J Hematol, 2013 Oct. PMID 24037419
    5. The cyclin-like protein Spy1 regulates growth and division characteristics of the CD133+ population in human glioma. Lubanska D, et al. Cancer Cell, 2014 Jan 13. PMID 24434210

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Salicylidene acylhydrazides attenuate survival of SH-SY5Y neuroblastoma cells through affecting mitotic regulator Speedy/RINGO and ERK/MAPK-PI3K/AKT signaling.
      Title: Salicylidene acylhydrazides attenuate survival of SH-SY5Y neuroblastoma cells through affecting mitotic regulator Speedy/RINGO and ERK/MAPK-PI3K/AKT signaling.
    2. The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
      Title: The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
    3. Speedy/RINGO protein interacts with ERK/MAPK and PI3K/AKT pathways in SH-SY5Y neuroblastoma cells.
      Title: Speedy/RINGO protein interacts with ERK/MAPK and PI3K/AKT pathways in SH-SY5Y neuroblastoma cells.
    4. This mouse model demonstrates for the first time that degradation of the cyclin-like protein Spy1 is an essential component of p53-mediated tumour suppression. Targeting cyclin-like protein activity may therefore represent a mechanism of re-sensitizing cells to important cell cycle checkpoints in a therapeutic setting.
      Title: The atypical cyclin-like protein Spy1 overrides p53-mediated tumour suppression and promotes susceptibility to breast tumourigenesis.
    5. Authors demonstrate that mammalian Spy1-mediated ERK activation increases ligand-independent phosphorylation and activation of estrogen receptor alpha, correlating with a decrease in tamoxifen sensitivity.
      Title: The cyclin-like protein, SPY1, regulates the ERα and ERK1/2 pathways promoting tamoxifen resistance.
    6. The authors find that Spy1 confers structural changes to Cdk2 that obviate the requirement of Cdk activation loop phosphorylation.
      Title: Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins.
    7. CRMP1 interacted with Spy1 which would disturb the association of CRMP1 with actin and was involved in the collapse of growth cones induced by Sema3A and regeneration after sciatic nerve crush.
      Title: CRMP1 Interacted with Spy1 During the Collapse of Growth Cones Induced by Sema3A and Acted on Regeneration After Sciatic Nerve Crush.
    8. Spy1 participates in the proliferation and apoptosis of epithelial ovarian cancer.
      Title: Spy1 participates in the proliferation and apoptosis of epithelial ovarian cancer.
    9. A novel Spy1-CLIPR-59 interplay was identified in glioblastoma resistance to TNF-alpha.
      Title: Spy1 induces de-ubiquitinating of RIP1 arrest and confers glioblastoma's resistance to tumor necrosis factor (TNF-α)-induced apoptosis through suppressing the association of CLIPR-59 and CYLD.
    10. Cell adhesion to fibronectin down-regulates the expression of Spy1 and contributes to drug resistance in multiple myeloma cells.
      Title: Cell adhesion to fibronectin down-regulates the expression of Spy1 and contributes to drug resistance in multiple myeloma cells.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: PPP1CB

    Homology

    Clone Names

    • MGC57218, MGC110856

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in establishment of protein localization to telomere IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male meiotic nuclear division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in meiotic attachment of telomere to nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in XY body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    speedy protein A
    Names
    RINGO A
    epididymis secretory sperm binding protein
    hSpy/Ringo A
    rapid inducer of G2/M progression in oocytes A
    speedy homolog A
    speedy-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008779.1 → NP_001008779.1  speedy protein A isoform 2

      See identical proteins and their annotated locations for NP_001008779.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks some 5' UTR sequence and uses a different splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AA625975, AY820303, BC047224
      UniProtKB/Swiss-Prot
      Q5MJ70
      Conserved Domains (1) summary
      pfam11357
      Location:69 → 199
      Spy1; Cell cycle regulatory protein

    2. NM_001142634.2 → NP_001136106.1  speedy protein A isoform 1

      See identical proteins and their annotated locations for NP_001136106.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1 and 3 both encode the longer protein (isoform 1).
      Source sequence(s)
      AY820304, BC047224, BC093005
      Consensus CDS
      CCDS1767.2
      UniProtKB/Swiss-Prot
      Q53R05, Q5MJ69, Q5MJ70
      UniProtKB/TrEMBL
      A0A384MTT5
      Related
      ENSP00000368898.4, ENST00000379579.8
      Conserved Domains (1) summary
      pfam11357
      Location:69 → 199
      Spy1; Cell cycle regulatory protein

    3. NM_182756.4 → NP_877433.2  speedy protein A isoform 1

      See identical proteins and their annotated locations for NP_877433.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks a segment in the 5' UTR, compared to variant 3. Variants 1 and 3 both encode the longer protein (isoform 1).
      Source sequence(s)
      AY820304, BC047224, BC093005
      Consensus CDS
      CCDS1767.2
      UniProtKB/Swiss-Prot
      Q53R05, Q5MJ69, Q5MJ70
      UniProtKB/TrEMBL
      A0A384MTT5
      Related
      ENSP00000335628.5, ENST00000334056.10
      Conserved Domains (1) summary
      pfam11357
      Location:69 → 199
      Spy1; Cell cycle regulatory protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      28810834..28850610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      28854444..28894219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5MJ70.2 GenPept UniProtKB/Swiss-Prot:Q5MJ70

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools