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    RFPL4B ret finger protein like 4B [ Homo sapiens (human) ]

    Gene ID: 442247, updated on 14-Nov-2024

    Summary

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    Official Symbol
    RFPL4Bprovided by HGNC
    Official Full Name
    ret finger protein like 4Bprovided by HGNC
    Primary source
    HGNC:HGNC:33264
    See related
    Ensembl:ENSG00000251258 AllianceGenome:HGNC:33264
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF211
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and regulation of gene expression. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See RFPL4B in Genome Data Viewer
    Location:
    6q21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (112347330..112351294)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (113493205..113534708)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (112668532..112672496)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene LAMA4 antisense RNA 1 Neighboring gene uncharacterized LOC107986632 Neighboring gene PIN2 (TERF1) interacting telomerase inhibitor 1 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:112649857-112650442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:112683751-112684250 Neighboring gene ribosomal protein SA pseudogene 45 Neighboring gene keratin 18 pseudogene 65

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ret finger protein-like 4B
    Names
    RING finger protein 211

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013734.3 → NP_001013756.2  ret finger protein-like 4B

      See identical proteins and their annotated locations for NP_001013756.2

      Status: VALIDATED

      Source sequence(s)
      AK122906, AL365214, BC132796
      Consensus CDS
      CCDS34515.1
      UniProtKB/Swiss-Prot
      A2RU91, Q6ZWI9
      Related
      ENSP00000423391.1, ENST00000441065.3
      Conserved Domains (2) summary
      cd16564
      Location:10 → 53
      RING-HC_RNF222; RING finger, HC subclass, found in RING finger protein 222 (RNF222) and similar proteins
      cl02614
      Location:93 → 262
      SPRY; SPRY domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      112347330..112351294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      113493205..113534708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355519.1 → XP_054211494.1  ret finger protein-like 4B isoform X1

      UniProtKB/Swiss-Prot
      A2RU91, Q6ZWI9

    2. XM_054355518.1 → XP_054211493.1  ret finger protein-like 4B isoform X1

      UniProtKB/Swiss-Prot
      A2RU91, Q6ZWI9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZWI9.2 GenPept UniProtKB/Swiss-Prot:Q6ZWI9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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