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    MAPK15 mitogen-activated protein kinase 15 [ Homo sapiens (human) ]

    Gene ID: 225689, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MAPK15provided by HGNC
    Official Full Name
    mitogen-activated protein kinase 15provided by HGNC
    Primary source
    HGNC:HGNC:24667
    See related
    Ensembl:ENSG00000181085 MIM:618616; AllianceGenome:HGNC:24667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERK7; ERK8
    Summary
    Enables MAP kinase activity and chromatin binding activity. Involved in several processes, including dopamine uptake; protein localization to ciliary transition zone; and regulation of organelle organization. Located in several cellular components, including Golgi apparatus; autophagosome; and microtubule organizing center. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in lung (RPKM 5.3), testis (RPKM 4.6) and 9 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MAPK15 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (143716349..143722458)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (144872787..144878895)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144798519..144804628)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144781964-144782464 Neighboring gene long intergenic non-protein coding RNA 2878 Neighboring gene uncharacterized LOC101928160 Neighboring gene coiled-coil domain containing 166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144805293-144805794 Neighboring gene family with sequence similarity 83 member H Neighboring gene Sharpr-MPRA regulatory region 4007 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144819935-144820800 Neighboring gene microRNA 4664 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144822529-144823392 Neighboring gene IQ motif and ankyrin repeat containing 1 Neighboring gene SREBF pathway regulator in golgi 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Mitogen-Activated Protein Kinase 15 Is a New Predictive Biomarker and Potential Therapeutic Target for Ovarian Cancer. Zhong QH, et al. Int J Mol Sci, 2023 Dec 20. PMID 38203280, Free PMC Article
    2. Characterization of the reversible phosphorylation and activation of ERK8. Klevernic IV, et al. Biochem J, 2006 Feb 15. PMID 16336213, Free PMC Article
    3. MAPK15 protects from oxidative stress-dependent cellular senescence by inducing the mitophagic process. Franci L, et al. Aging Cell, 2022 Jul. PMID 35642724, Free PMC Article
    4. Structure prediction and validation of the ERK8 kinase domain. Strambi A, et al. PLoS One, 2013. PMID 23326322, Free PMC Article
    5. MAPK15 upregulation promotes cell proliferation and prevents DNA damage in male germ cell tumors. Rossi M, et al. Oncotarget, 2016 Apr 12. PMID 26988910, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAPK15 controls cellular responses to oxidative stress by regulating NRF2 activity and expression of its downstream target genes.
      Title: MAPK15 controls cellular responses to oxidative stress by regulating NRF2 activity and expression of its downstream target genes.
    2. Mitogen-Activated Protein Kinase 15 Is a New Predictive Biomarker and Potential Therapeutic Target for Ovarian Cancer.
      Title: Mitogen-Activated Protein Kinase 15 Is a New Predictive Biomarker and Potential Therapeutic Target for Ovarian Cancer.
    3. MAPK15 protects from oxidative stress-dependent cellular senescence by inducing the mitophagic process.
      Title: MAPK15 protects from oxidative stress-dependent cellular senescence by inducing the mitophagic process.
    4. MAPK15-ULK1 signaling regulates mitophagy of airway epithelial cell in chronic obstructive pulmonary disease.
      Title: MAPK15-ULK1 signaling regulates mitophagy of airway epithelial cell in chronic obstructive pulmonary disease.
    5. As multiple roles of MAPK15 were observed among these studies, therefore, it remains unclear whether MAPK15 acts as a proto-oncogene or tumor suppressor. Here, the recent literature on human MAPK15 and the resulting functions will be discussed.
      Title: Regulation of human mitogen-activated protein kinase 15 (extracellular signal-regulated kinase 7/8) and its functions: A recent update.
    6. MAPK15 stimulates ULK1, is part of the ULK complex, colocalizes in autophagosomes, and is involved in autophagosome biogenesis.
      Title: MAPK15 is part of the ULK complex and controls its activity to regulate early phases of the autophagic process.
    7. Our results describe a primary cilia-related role for this poorly studied member of the MAPK family in vivo, and indicate a broad requirement for MAPK15 in the formation of multiple ciliary classes across species.
      Title: Primary Cilium Formation and Ciliary Protein Trafficking Is Regulated by the Atypical MAP Kinase MAPK15 in Caenorhabditis elegans and Human Cells.
    8. High MAPK15 expression is associated with male germ cell tumors.
      Title: MAPK15 upregulation promotes cell proliferation and prevents DNA damage in male germ cell tumors.
    9. In HeLa cells, phosphorylation of HuR by ERK8 prevents it from binding to PDCD4 mRNA and allows miR-21-mediated degradation of PDCD4.
      Title: ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism.
    10. depletion of endogenous MAPK15 expression inhibited BCR-ABL1-dependent cell proliferation, in vitro
      Title: MAPK15 mediates BCR-ABL1-induced autophagy and regulates oncogene-dependent cell proliferation and tumor formation.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR) PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SH3 domain binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dopamine uptake IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of metaphase/anaphase transition of meiosis I IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of spindle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of positive regulation of telomere maintenance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to ciliary transition zone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of COPII vesicle coating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in meiotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitogen-activated protein kinase 15
    Names
    ERK-7
    ERK-8
    MAP kinase 15
    MAPK 15
    extracellular regulated kinase 8 delta
    extracellular signal-regulated kinase 7
    extracellular signal-regulated kinase 8
    NP_620590.2
    XP_011515227.1
    XP_011515228.1
    XP_011515229.1
    XP_011515230.1
    XP_047277522.1
    XP_047277523.1
    XP_047277524.1
    XP_054184724.1
    XP_054184725.1
    XP_054184726.1
    XP_054184727.1
    XP_054184728.1
    XP_054184729.1
    XP_054184730.1
    XP_054216067.1
    XP_054216068.1
    XP_054216069.1
    XP_054216070.1
    XP_054216071.1
    XP_054216072.1
    XP_054216073.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139021.3 → NP_620590.2  mitogen-activated protein kinase 15

      See identical proteins and their annotated locations for NP_620590.2

      Status: VALIDATED

      Source sequence(s)
      AY065978, BP357805
      Consensus CDS
      CCDS6409.2
      UniProtKB/Swiss-Prot
      Q2TCF9, Q8N362, Q8TD08
      Related
      ENSP00000337691.4, ENST00000338033.9
      Conserved Domains (2) summary
      smart00220
      Location:13 → 304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07852
      Location:5 → 343
      STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      143716349..143722458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516926.3 → XP_011515228.1  mitogen-activated protein kinase 15 isoform X2

      See identical proteins and their annotated locations for XP_011515228.1

      Conserved Domains (2) summary
      smart00220
      Location:13 → 323
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07852
      Location:5 → 362
      STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

    2. XM_047421567.1 → XP_047277523.1  mitogen-activated protein kinase 15 isoform X5

    3. XM_047421568.1 → XP_047277524.1  mitogen-activated protein kinase 15 isoform X6

    4. XM_011516925.3 → XP_011515227.1  mitogen-activated protein kinase 15 isoform X1

      See identical proteins and their annotated locations for XP_011515227.1

      Conserved Domains (2) summary
      smart00220
      Location:25 → 325
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07852
      Location:25 → 364
      STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

    5. XM_047421566.1 → XP_047277522.1  mitogen-activated protein kinase 15 isoform X4

    6. XM_011516927.3 → XP_011515229.1  mitogen-activated protein kinase 15 isoform X3

      See identical proteins and their annotated locations for XP_011515229.1

      Conserved Domains (2) summary
      smart00220
      Location:25 → 306
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07852
      Location:25 → 345
      STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

    7. XM_011516928.3 → XP_011515230.1  mitogen-activated protein kinase 15 isoform X7

      See identical proteins and their annotated locations for XP_011515230.1

      Conserved Domains (2) summary
      smart00220
      Location:25 → 325
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07852
      Location:25 → 327
      STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

    RNA

    1. XR_001745494.2 RNA Sequence

    2. XR_001745493.2 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187571.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      193396..199505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328750.1 → XP_054184725.1  mitogen-activated protein kinase 15 isoform X2

    2. XM_054328753.1 → XP_054184728.1  mitogen-activated protein kinase 15 isoform X5

    3. XM_054328754.1 → XP_054184729.1  mitogen-activated protein kinase 15 isoform X6

    4. XM_054328749.1 → XP_054184724.1  mitogen-activated protein kinase 15 isoform X1

    5. XM_054328752.1 → XP_054184727.1  mitogen-activated protein kinase 15 isoform X4

    6. XM_054328751.1 → XP_054184726.1  mitogen-activated protein kinase 15 isoform X3

    7. XM_054328755.1 → XP_054184730.1  mitogen-activated protein kinase 15 isoform X7

    RNA

    1. XR_008485613.1 RNA Sequence

    2. XR_008485612.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      144872787..144878895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360093.1 → XP_054216068.1  mitogen-activated protein kinase 15 isoform X2

    2. XM_054360096.1 → XP_054216071.1  mitogen-activated protein kinase 15 isoform X5

    3. XM_054360097.1 → XP_054216072.1  mitogen-activated protein kinase 15 isoform X6

    4. XM_054360092.1 → XP_054216067.1  mitogen-activated protein kinase 15 isoform X1

    5. XM_054360095.1 → XP_054216070.1  mitogen-activated protein kinase 15 isoform X4

    6. XM_054360094.1 → XP_054216069.1  mitogen-activated protein kinase 15 isoform X3

    7. XM_054360098.1 → XP_054216073.1  mitogen-activated protein kinase 15 isoform X7

    RNA

    1. XR_008487821.1 RNA Sequence

    2. XR_008487820.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TD08.1 GenPept UniProtKB/Swiss-Prot:Q8TD08

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