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    ARPP19 cAMP regulated phosphoprotein 19 [ Homo sapiens (human) ]

    Gene ID: 10776, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ARPP19provided by HGNC
    Official Full Name
    cAMP regulated phosphoprotein 19provided by HGNC
    Primary source
    HGNC:HGNC:16967
    See related
    Ensembl:ENSG00000128989 MIM:605487; AllianceGenome:HGNC:16967
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ENSAL; ARPP16; ARPP-16; ARPP-19
    Summary
    The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011]
    Expression
    Ubiquitous expression in brain (RPKM 79.8), thyroid (RPKM 29.3) and 24 other tissues See more
    Orthologs
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    Genomic context

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    See ARPP19 in Genome Data Viewer
    Location:
    15q21.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (52547045..52569446, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (50355343..50377746, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (52839242..52861643, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene myosin VC Neighboring gene uncharacterized LOC105370819 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9426 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:52630438-52631014 Neighboring gene myosin VA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9429 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:52684277-52684953 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:52751737-52752632 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:52757960-52758715 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:52769819-52770320 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:52770321-52770820 Neighboring gene negCOR silencer S8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6447 Neighboring gene eukaryotic translation elongation factor 1 beta 2 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:52838153-52838654 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:52860078-52860826 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:52860827-52861573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9432 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:52904295-52904794 Neighboring gene atos homolog A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9434 Neighboring gene NANOG hESC enhancer GRCh37_chr15:52963789-52964290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9436 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6450 Neighboring gene uncharacterized LOC105370821 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:52979459-52979959 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9437 Neighboring gene Sharpr-MPRA regulatory region 217 Neighboring gene one cut homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease. Kim SH, et al. J Neural Transm Suppl, 2001. PMID 11771749
    2. Increased ARPP-19 expression is associated with hepatocellular carcinoma. Song H, et al. Int J Mol Sci, 2014 Dec 24. PMID 25547487, Free PMC Article
    3. ARPP-19 promotes proliferation and metastasis of human glioma. Jiang T, et al. Neuroreport, 2016 Sep 7. PMID 27380244
    4. Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. Padi SKR, et al. Nature, 2024 Jan. PMID 38123684, Free PMC Article
    5. Purification and cDNA cloning of ARPP-16, a cAMP-regulated phosphoprotein enriched in basal ganglia, and of a related phosphoprotein, ARPP-19. Horiuchi A, et al. J Biol Chem, 1990 Jun 5. PMID 2160982

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long Noncoding RNA DLX6-AS1 Promotes the Progression in Cervical Cancer by Targeting miR-16-5p/ARPP19 Axis.
      Title: Long Noncoding RNA DLX6-AS1 Promotes the Progression in Cervical Cancer by Targeting miR-16-5p/ARPP19 Axis.
    2. The cAMP-regulated phosphoprotein 19 (ARPP19) was a direct target of miR-802 and could reverse the inhibitory function of miR-802. These data suggest that the IGFL2-AS1/miR-802/ARPP19 axis plays a critical role in the progression and metastasis of gastric cancer.
      Title: LncRNA IGFL2-AS1 functions as a ceRNA in regulating ARPP19 through competitive binding to miR-802 in gastric cancer.
    3. Together, the results suggest a complex antagonistic interplay between the control of ARPP-16 by MAST3 and PKA that creates a mechanism whereby cAMP mediates PP2A disinhibition.
      Title: Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition.
    4. Study showed that ARPP-19 promoted both proliferation and metastasis of human glioma cells and the expression of ARPP-19 and CD147 in high-grade glioma was significantly higher than that in the low-grade glioma.
      Title: ARPP-19 promotes proliferation and metastasis of human glioma.
    5. Data show that micrRNA miR-320a directly targets cAMP-regulated phosphoprotein 19 (ARPP-19) and estrogen-related receptor gamma protein (ERRgamma) in breast cancer cell lines.
      Title: MicroRNA-320a sensitizes tamoxifen-resistant breast cancer cells to tamoxifen by targeting ARPP-19 and ERRγ.
    6. ARPP-19 may play a role in HCC pathogenesis through regulating cell proliferation.
      Title: Increased ARPP-19 expression is associated with hepatocellular carcinoma.
    7. ARPP19 gene expression is decreased in follicular variant of papillary thyroid carcinoma.
      Title: Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.
    8. Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease.
      Title: Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ41622

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase 2A binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein phosphatase 2A binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase 2A binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein phosphatase 2A binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein phosphatase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of D-glucose import NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of gluconeogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    cAMP-regulated phosphoprotein 19
    Names
    cAMP-regulated phosphoprotein 19kDa
    cyclic AMP phosphoprotein, 19 kD

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306191.2 → NP_001293120.1  cAMP-regulated phosphoprotein 19 isoform 1

      See identical proteins and their annotated locations for NP_001293120.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode isoform 1.
      Source sequence(s)
      AC025917
      Consensus CDS
      CCDS76757.1
      UniProtKB/TrEMBL
      H3BMD8
      Related
      ENSP00000454341.1, ENST00000561971.1
      Conserved Domains (1) summary
      pfam04667
      Location:47 → 122
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    2. NM_001306195.1 → NP_001293124.1  cAMP-regulated phosphoprotein 19 isoform 2

      See identical proteins and their annotated locations for NP_001293124.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame exon in the CDS. The encoded isoform (2) is shorter than isoform 1. Both variants 3 and 4 encode isoform 2.
      Source sequence(s)
      AC025917, AL833077, DA647638
      Consensus CDS
      CCDS32242.1
      UniProtKB/Swiss-Prot
      B2R497, P56211, Q6IAM2, Q86TA6, Q9UD70
      Related
      ENSP00000455625.1, ENST00000566423.5
      Conserved Domains (1) summary
      pfam04667
      Location:28 → 103
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    3. NM_001306196.2 → NP_001293125.1  cAMP-regulated phosphoprotein 19 isoform 1

      See identical proteins and their annotated locations for NP_001293125.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC025917
      Consensus CDS
      CCDS76757.1
      UniProtKB/TrEMBL
      H3BMD8
      Related
      ENSP00000454612.1, ENST00000564163.5
      Conserved Domains (1) summary
      pfam04667
      Location:47 → 122
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    4. NM_001330309.2 → NP_001317238.1  cAMP-regulated phosphoprotein 19 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' structure, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC025917
      Consensus CDS
      CCDS81883.1
      UniProtKB/Swiss-Prot
      P56211
      Related
      ENSP00000454234.1, ENST00000561650.5
      Conserved Domains (1) summary
      pfam04667
      Location:12 → 87
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    5. NM_006628.6 → NP_006619.1  cAMP-regulated phosphoprotein 19 isoform 2

      See identical proteins and their annotated locations for NP_006619.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the CDS. The encoded isoform (2) is shorter than isoform 1. Both variants 3 and 4 encode isoform 2.
      Source sequence(s)
      AC025917
      Consensus CDS
      CCDS32242.1
      UniProtKB/Swiss-Prot
      B2R497, P56211, Q6IAM2, Q86TA6, Q9UD70
      Related
      ENSP00000249822.4, ENST00000249822.9
      Conserved Domains (1) summary
      pfam04667
      Location:28 → 103
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      52547045..52569446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021870.3 → XP_016877359.1  cAMP-regulated phosphoprotein 19 isoform X4

      UniProtKB/Swiss-Prot
      P56211
      Related
      ENSP00000455986.1, ENST00000563277.5
      Conserved Domains (1) summary
      pfam04667
      Location:12 → 87
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    2. XM_047432112.1 → XP_047288068.1  cAMP-regulated phosphoprotein 19 isoform X2

      UniProtKB/Swiss-Prot
      B2R497, P56211, Q6IAM2, Q86TA6, Q9UD70
      Related
      ENSP00000455151.1, ENST00000567669.5

    3. XM_047432111.1 → XP_047288067.1  cAMP-regulated phosphoprotein 19 isoform X1

      UniProtKB/TrEMBL
      H3BMD8

    4. XM_047432113.1 → XP_047288069.1  cAMP-regulated phosphoprotein 19 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      50355343..50377746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377215.1 → XP_054233190.1  cAMP-regulated phosphoprotein 19 isoform X4

    2. XM_054377213.1 → XP_054233188.1  cAMP-regulated phosphoprotein 19 isoform X2

      UniProtKB/Swiss-Prot
      B2R497, P56211, Q6IAM2, Q86TA6, Q9UD70

    3. XM_054377212.1 → XP_054233187.1  cAMP-regulated phosphoprotein 19 isoform X1

      UniProtKB/TrEMBL
      H3BMD8

    4. XM_054377214.1 → XP_054233189.1  cAMP-regulated phosphoprotein 19 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56211.2 GenPept UniProtKB/Swiss-Prot:P56211

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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