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    LETMD1 LETM1 domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 25875, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LETMD1provided by HGNC
    Official Full Name
    LETM1 domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:24241
    See related
    Ensembl:ENSG00000050426 MIM:619070; AllianceGenome:HGNC:24241
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCCR; HCCR1; HCCR2; HCCR-1; HCCR-2; HCRR-2; SLC55A3; 1110019O13Rik
    Summary
    This gene encodes a mitochondrial outer membrane protein. It has a potential role in tumorigenesis, which may result from negative regulation of the p53 tumor suppressor gene. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 15.5), fat (RPKM 12.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LETMD1 in Genome Data Viewer
    Location:
    12q13.12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (51048220..51068958)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (51011103..51031877)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (51442003..51462741)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 11 member 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51419127-51419740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51419741-51420352 Neighboring gene RNA, U6 small nuclear 87, pseudogene Neighboring gene RNA, U6 small nuclear 1273, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6367 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51441816-51442354 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51442355-51442893 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51463214-51463714 Neighboring gene cysteine and serine rich nuclear protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:51477804-51478430 Neighboring gene transcription factor CP2 Neighboring gene ribosomal protein L35a pseudogene 29 Neighboring gene PHB1 pseudogene 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Clinical implication of elevated human cervical cancer oncogene-1 expression in esophageal squamous cell carcinoma. Liu Y, et al. J Histochem Cytochem, 2012 Jul. PMID 22511601, Free PMC Article
    2. Silencing HCCR2 expression inhibits the proliferation of leukemia cells by inducing apoptosis and promoting cell cycle arrest. Qiao SK, et al. Int J Mol Med, 2013 Dec. PMID 24126909
    3. Transdifferentiation-inducing HCCR-1 oncogene. Ha SA, et al. BMC Cell Biol, 2010 Jun 30. PMID 20591135, Free PMC Article
    4. Quantitative detection of the human cervical cancer oncogene for monitoring the minimal residual disease in acute leukemia. Qiao SK, et al. Exp Biol Med (Maywood), 2015 Jan. PMID 25034723, Free PMC Article
    5. HCCR-1, a novel oncogene, encodes a mitochondrial outer membrane protein and suppresses the UVC-induced apoptosis. Cho GW, et al. BMC Cell Biol, 2007 Nov 28. PMID 18045496, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LETMD1, a target of KLF4, hinders endothelial inflammation and pyroptosis: A protective mechanism in the pathogenesis of atherosclerosis.
      Title: LETMD1, a target of KLF4, hinders endothelial inflammation and pyroptosis: A protective mechanism in the pathogenesis of atherosclerosis.
    2. MiR-494 Inhibits the Proliferation, Migration and Invasion of Cervical Cancer Cells by Regulating LETMD1.
      Title: MiR-494 Inhibits the Proliferation, Migration and Invasion of Cervical Cancer Cells by Regulating LETMD1.
    3. The regulating role of miR-494 on HCCR1 in cervical cancer cells.
      Title: The regulating role of miR-494 on HCCR1 in cervical cancer cells.
    4. Knockdown of SNHG1 inhibits cervical cancer growth through sponging miR-194 to regulate HCCR.
      Title: Knockdown of SNHG1 inhibits cervical cancer growth through sponging miR-194 to regulate HCCR.
    5. LETMD1 Regulates Phagocytosis and Inflammatory Responses to Lipopolysaccharide via Reactive Oxygen Species Generation and NF-kappaB Activation in Macrophages.
      Title: LETMD1 Regulates Phagocytosis and Inflammatory Responses to Lipopolysaccharide via Reactive Oxygen Species Generation and NF-κB Activation in Macrophages.
    6. HCCR-1 siRNA transfection causes significant increase in the apoptosis and decreases in the proliferation of MCF-7 cellsThese effects are related to the upregulation of the Bax expression in the MCF-7 cells.
      Title: Interaction of HCCR-1 and Bax in breast cancer.
    7. Data show that the activation of STAT3 protein upregulated human cervical cancer oncogene (HCCR) expression in gastric cancer cells.
      Title: Targeting HCCR expression resensitizes gastric cancer cells to chemotherapy via down-regulating the activation of STAT3.
    8. Demonstrate that HBx-HCCR-E-cadherin regulation pathway might play an important role in HBV-induced hepatocarcinogenesis.
      Title: Up-regulation of human cervical cancer proto-oncogene contributes to hepatitis B virus-induced malignant transformation of hepatocyte by down-regulating E-cadherin.
    9. These findings suggest that HCCR gene is over-expressed in acute leukemia patients and may be a useful biomarker for monitoring minimal residual disease.
      Title: Quantitative detection of the human cervical cancer oncogene for monitoring the minimal residual disease in acute leukemia.
    10. HCCR2 gene plays an important role in the tumorigenesis of leukemia.
      Title: Silencing HCCR2 expression inhibits the proliferation of leukemia cells by inducing apoptosis and promoting cell cycle arrest.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp586A011

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LETM1 domain-containing protein 1
    Names
    cervical cancer 1 proto-oncogene protein p40
    cervical cancer proto-oncogene 2 protein
    epididymis secretory sperm binding protein
    human cervical cancer oncogene
    regulator of TP53

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029858.3 RefSeqGene

      Range
      5109..17206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001243689.2 → NP_001230618.1  LETM1 domain-containing protein 1 isoform b

      See identical proteins and their annotated locations for NP_001230618.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame donor splice site at an internal exon in the 5' coding region compared to variant 1. This results in a longer isoform (b, also known as 3) containing a 13 aa protein segment not found in isoform 1.
      Source sequence(s)
      AC087884
      Consensus CDS
      CCDS58231.1
      UniProtKB/TrEMBL
      B2RCH7
      Related
      ENSP00000389903.2, ENST00000418425.6
      Conserved Domains (1) summary
      pfam07766
      Location:80 → 351
      LETM1; LETM1-like protein

    2. NM_001300765.2 → NP_001287694.1  LETM1 domain-containing protein 1 isoform c

      See identical proteins and their annotated locations for NP_001287694.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks three alternate in-frame exons in the central coding region, compared to variant 1. The encoded isoform (c, also known as 7) is shorter than isoform 1.
      Source sequence(s)
      AC087884
      Consensus CDS
      CCDS73469.1
      UniProtKB/TrEMBL
      F8W1Z2
      Related
      ENSP00000447419.1, ENST00000547008.5
      Conserved Domains (1) summary
      pfam07766
      Location:79 → 221
      LETM1; LETM1-like protein

    3. NM_001351312.2 → NP_001338241.1  LETM1 domain-containing protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variant 12, encodes isoform d.
      Source sequence(s)
      AC087884
      Consensus CDS
      CCDS44883.1
      UniProtKB/TrEMBL
      B7Z7F8
      Related
      ENSP00000450163.1, ENST00000550929.5
      Conserved Domains (1) summary
      pfam07766
      Location:23 → 289
      LETM1; LETM1-like protein

    4. NM_001351313.2 → NP_001338242.1  LETM1 domain-containing protein 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 25-27, encodes isoform e.
      Source sequence(s)
      AC087884
      Conserved Domains (1) summary
      pfam07766
      Location:1 → 188
      LETM1; LETM1-like protein

    5. NM_001351315.2 → NP_001338244.1  LETM1 domain-containing protein 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC087884
      UniProtKB/TrEMBL
      B2RCH7
      Conserved Domains (1) summary
      pfam07766
      Location:86 → 352
      LETM1; LETM1-like protein

    6. NM_001351316.2 → NP_001338245.1  LETM1 domain-containing protein 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC087884
      UniProtKB/TrEMBL
      B2RCH7
      Conserved Domains (1) summary
      pfam07766
      Location:86 → 312
      LETM1; LETM1-like protein

    7. NM_001351317.2 → NP_001338246.1  LETM1 domain-containing protein 1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC087884
      UniProtKB/TrEMBL
      B2RCH7
      Conserved Domains (1) summary
      pfam07766
      Location:79 → 305
      LETM1; LETM1-like protein

    8. NM_001351319.2 → NP_001338248.1  LETM1 domain-containing protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variant 2, encodes isoform d.
      Source sequence(s)
      AC087884
      Consensus CDS
      CCDS44883.1
      UniProtKB/TrEMBL
      B7Z7F8
      Conserved Domains (1) summary
      pfam07766
      Location:23 → 289
      LETM1; LETM1-like protein

    9. NM_001351320.2 → NP_001338249.1  LETM1 domain-containing protein 1 isoform k

      Status: REVIEWED

      Source sequence(s)
      AC087884
      UniProtKB/TrEMBL
      F8VZA2
      Conserved Domains (1) summary
      pfam07766
      Location:23 → 249
      LETM1; LETM1-like protein

    10. NM_001351321.2 → NP_001338250.1  LETM1 domain-containing protein 1 isoform l

      Status: REVIEWED

      Source sequence(s)
      AC087884
      Conserved Domains (1) summary
      pfam07766
      Location:79 → 255
      LETM1; LETM1-like protein

    11. NM_001351322.2 → NP_001338251.1  LETM1 domain-containing protein 1 isoform m

      Status: REVIEWED

      Source sequence(s)
      AC087884
      UniProtKB/TrEMBL
      B7Z7F8
      Conserved Domains (1) summary
      pfam07766
      Location:1 → 251
      LETM1; LETM1-like protein

    12. NM_001351323.2 → NP_001338252.1  LETM1 domain-containing protein 1 isoform m

      Status: REVIEWED

      Source sequence(s)
      AC087884
      UniProtKB/TrEMBL
      B7Z7F8
      Conserved Domains (1) summary
      pfam07766
      Location:1 → 251
      LETM1; LETM1-like protein

    13. NM_001351324.2 → NP_001338253.1  LETM1 domain-containing protein 1 isoform m

      Status: REVIEWED

      Source sequence(s)
      AC087884
      UniProtKB/TrEMBL
      B7Z7F8
      Conserved Domains (1) summary
      pfam07766
      Location:1 → 251
      LETM1; LETM1-like protein

    14. NM_001351325.2 → NP_001338254.1  LETM1 domain-containing protein 1 isoform n

      Status: REVIEWED

      Source sequence(s)
      AC087884
      Conserved Domains (1) summary
      pfam07766
      Location:116 → 244
      LETM1; LETM1-like protein

    15. NM_001351326.2 → NP_001338255.1  LETM1 domain-containing protein 1 isoform o

      Status: REVIEWED

      Source sequence(s)
      AC087884
      UniProtKB/TrEMBL
      B7Z7F8
      Conserved Domains (1) summary
      pfam07766
      Location:37 → 239
      LETM1; LETM1-like protein

    16. NM_001351327.2 → NP_001338256.1  LETM1 domain-containing protein 1 isoform o

      Status: REVIEWED

      Source sequence(s)
      AC087884
      UniProtKB/TrEMBL
      B7Z7F8
      Conserved Domains (1) summary
      pfam07766
      Location:37 → 239
      LETM1; LETM1-like protein

    17. NM_001351328.2 → NP_001338257.1  LETM1 domain-containing protein 1 isoform p

      Status: REVIEWED

      Source sequence(s)
      AC087884
      Conserved Domains (1) summary
      pfam07766
      Location:86 → 228
      LETM1; LETM1-like protein

    18. NM_001351330.2 → NP_001338259.1  LETM1 domain-containing protein 1 isoform t

      Status: REVIEWED

      Source sequence(s)
      AC087884
      Consensus CDS
      CCDS86301.1
      UniProtKB/TrEMBL
      F8VP71
      Related
      ENSP00000450333.1, ENST00000552739.5
      Conserved Domains (1) summary
      pfam07766
      Location:42 → 228
      LETM1; LETM1-like protein

    19. NM_001351332.2 → NP_001338261.1  LETM1 domain-containing protein 1 isoform u

      Status: REVIEWED

      Source sequence(s)
      AC087884
      Conserved Domains (1) summary
      pfam07766
      Location:93 → 228
      LETM1; LETM1-like protein

    20. NM_001351333.2 → NP_001338262.1  LETM1 domain-containing protein 1 isoform q

      Status: REVIEWED

      Source sequence(s)
      AC087884
      Conserved Domains (1) summary
      pfam07766
      Location:79 → 181
      LETM1; LETM1-like protein

    21. NM_001351334.2 → NP_001338263.1  LETM1 domain-containing protein 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variants 4, 26, and 27, encodes isoform e (also called isoform r).
      Source sequence(s)
      AC087884
      Conserved Domains (1) summary
      pfam07766
      Location:1 → 188
      LETM1; LETM1-like protein

    22. NM_001351335.2 → NP_001338264.1  LETM1 domain-containing protein 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26), as well as variants 4, 25, and 27, encodes isoform e (also called isoform r).
      Source sequence(s)
      AC087884
      Conserved Domains (1) summary
      pfam07766
      Location:1 → 188
      LETM1; LETM1-like protein

    23. NM_001351336.2 → NP_001338265.1  LETM1 domain-containing protein 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27), as well as variants 4, 25, and 26, encodes isoform e (also called isoform r).
      Source sequence(s)
      AC087884
      Conserved Domains (1) summary
      pfam07766
      Location:1 → 188
      LETM1; LETM1-like protein

    24. NM_001351337.2 → NP_001338266.1  LETM1 domain-containing protein 1 isoform s

      Status: REVIEWED

      Source sequence(s)
      AC087884, KF455649
      Conserved Domains (1) summary
      pfam07766
      Location:79 → 181
      LETM1; LETM1-like protein

    25. NM_015416.5 → NP_056231.3  LETM1 domain-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_056231.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant protein-coding transcript, and encodes isoform a (also known as HCCR-1 or 1).
      Source sequence(s)
      AC087884
      Consensus CDS
      CCDS8806.1
      UniProtKB/Swiss-Prot
      A6NER7, B3KXK7, Q6P1Q0, Q6X2E4, Q6X2E5, Q7L2G9, Q7L690, Q8WXW6, Q96PK7, Q9BY59, Q9Y3X3
      UniProtKB/TrEMBL
      A0A384P5D7, B2RCH7
      Related
      ENSP00000262055.4, ENST00000262055.9
      Conserved Domains (1) summary
      pfam07766
      Location:79 → 345
      LETM1; LETM1-like protein

    RNA

    1. NR_045019.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two consecutive exons compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with the translation of the longest ORF; translation of the upstream ORF renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC087884
      Related
      ENST00000547318.5

    2. NR_045020.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884, KF455649

    3. NR_147098.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884, BU688852

    4. NR_147099.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    5. NR_147100.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    6. NR_147101.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    7. NR_147102.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    8. NR_147103.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    9. NR_147104.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    10. NR_147105.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    11. NR_147106.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    12. NR_147107.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    13. NR_147108.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    14. NR_147109.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    15. NR_147110.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    16. NR_147111.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    17. NR_147112.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884
      Related
      ENST00000550100.5

    18. NR_147113.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884
      Related
      ENST00000547555.5

    19. NR_147114.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    20. NR_147115.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884
      Related
      ENST00000380135.7

    21. NR_147116.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    22. NR_147117.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    23. NR_147118.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    24. NR_147119.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    25. NR_147120.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      51048220..51068958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428688.1 → XP_047284644.1  LETM1 domain-containing protein 1 isoform X2

    2. XM_047428687.1 → XP_047284643.1  LETM1 domain-containing protein 1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      51011103..51031877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371706.1 → XP_054227681.1  LETM1 domain-containing protein 1 isoform X2

    2. XM_054371705.1 → XP_054227680.1  LETM1 domain-containing protein 1 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024668.1: Suppressed sequence

      Description
      NM_001024668.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_001024669.1: Suppressed sequence

      Description
      NM_001024669.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    3. NM_001024670.1: Suppressed sequence

      Description
      NM_001024670.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    4. NM_001024671.1: Suppressed sequence

      Description
      NM_001024671.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P1Q0.1 GenPept UniProtKB/Swiss-Prot:Q6P1Q0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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