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    C53D5.5 Gamma-glutamyltranspeptidase 1 [ Caenorhabditis elegans ]

    Gene ID: 171619, updated on 2-Nov-2024

    Summary

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    Official Symbol
    C53D5.5
    Official Full Name
    Gamma-glutamyltranspeptidase 1
    Primary source
    WormBase:WBGene00016906
    Locus tag
    CELE_C53D5.5
    See related
    AllianceGenome:WB:WBGene00016906
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutathione hydrolase activity. Predicted to be involved in glutathione catabolic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to several human genes including GGT1 (gamma-glutamyltransferase 1) and GGT2P (gamma-glutamyltransferase 2, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See C53D5.5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (305811..310790, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RING-CH-type domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene FAM69 protein-kinase domain-containing protein Neighboring gene Importin N-terminal domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    2. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Gamma-glutamyltranspeptidase 1
    NP_001364826.1
    • Confirmed by transcript evidence
    NP_490714.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      305811..310790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058313.7 → NP_490714.1  Gamma-glutamyltranspeptidase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490714.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N5V4
      Conserved Domains (1) summary
      pfam01019
      Location:119 → 633
      G_glu_transpept; Gamma-glutamyltranspeptidase

    2. NM_001377821.2 → NP_001364826.1  Gamma-glutamyltranspeptidase 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLP9
      Conserved Domains (1) summary
      pfam01019
      Location:72 → 587
      G_glu_transpept; Gamma-glutamyltranspeptidase
    Nucleotide Protein
    Heading Accession and Version

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