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    ARC19 Arc19p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853856, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ARC19
    Official Full Name
    Arc19p
    Primary source
    SGD:S000001496
    Locus tag
    YKL013C
    See related
    AllianceGenome:SGD:S000001496; FungiDB:YKL013C; VEuPathDB:YKL013C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables molecular adaptor activity. Involved in actin cortical patch organization. Part of Arp2/3 protein complex. Used to study cancer. Orthologous to several human genes including ARPC4-TTLL3 (ARPC4-TTLL3 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ARC19 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (417508..418023, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Put3p Neighboring gene Urb1p Neighboring gene Prp40p Neighboring gene cruciform cutting endonuclease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Affinity filtration coupled with capillary-based affinity purification for the isolation of protein complexes. Qureshi MS, et al. Anal Biochem, 2013 Aug 1. PMID 23583819
    2. Purification of Arp2/3 complex from Saccharomyces cerevisiae. Doolittle LK, et al. Methods Mol Biol, 2013. PMID 23868593, Free PMC Article
    3. Functional surfaces on the p35/ARPC2 subunit of Arp2/3 complex required for cell growth, actin nucleation, and endocytosis. Daugherty KM, et al. J Biol Chem, 2008 Jun 13. PMID 18381280, Free PMC Article
    4. Mechanism of filament nucleation and branch stability revealed by the structure of the Arp2/3 complex at actin branch junctions. Egile C, et al. PLoS Biol, 2005 Nov. PMID 16262445, Free PMC Article
    5. Cofilin, but not profilin, is required for myosin-I-induced actin polymerization and the endocytic uptake in yeast. Idrissi FZ, et al. Mol Biol Cell, 2002 Nov. PMID 12429847, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin cortical patch organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Arp2/3 protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Arp2/3 protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Arc19p
    NP_012912.1
    • Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; mutation is functionally complemented by human ARPC4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      417508..418023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179579.1 → NP_012912.1  TPA: Arc19p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012912.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXS3, P33204
      UniProtKB/TrEMBL
      A6ZZV2, B3LR71, C7GRH2, C8ZCF4, G2WI18, N1NZB9
      Conserved Domains (1) summary
      pfam05856
      Location:1 → 166
      ARPC4; ARP2/3 complex 20 kDa subunit (ARPC4)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33204.2

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