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    CWH41 mannosyl-oligosaccharide glucosidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852857, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CWH41
    Official Full Name
    mannosyl-oligosaccharide glucosidase
    Primary source
    SGD:S000002995
    Locus tag
    YGL027C
    See related
    AllianceGenome:SGD:S000002995; FungiDB:YGL027C; VEuPathDB:YGL027C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DER7; GLS1
    Summary
    Enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity. Involved in fungal-type cell wall beta-glucan biosynthetic process and protein N-linked glycosylation. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIb. Orthologous to human MOGS (mannosyl-oligosaccharide glucosidase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CWH41 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (443642..446143, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-Phe Neighboring gene putative glucan endo-1,3-beta-D-glucosidase Neighboring gene tryptophan synthase TRP5 Neighboring gene Pgd1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Specificity of Processing α-glucosidase I is guided by the substrate conformation: crystallographic and in silico studies. Barker MK, et al. J Biol Chem, 2013 May 10. PMID 23536181, Free PMC Article
    2. Cellular zwitterionic metabolite analogs simultaneously enhance reaction rate, thermostability, salt tolerance, and substrate specificity of α-glucosidase. Deguchi E, et al. Bioorg Med Chem, 2011 May 15. PMID 21524914
    3. Truncations and functional carboxylic acid residues of yeast processing alpha-glucosidase I. Faridmoayer A, et al. Glycoconj J, 2007 Nov. PMID 17458696
    4. Binding residues and catalytic domain of soluble Saccharomyces cerevisiae processing alpha-glucosidase I. Faridmoayer A, et al. Glycobiology, 2005 Dec. PMID 16014748
    5. An improved purification procedure for soluble processing alpha-glucosidase I from Saccharomyces cerevisiae overexpressing CWH41. Faridmoayer A, et al. Protein Expr Purif, 2004 Jan. PMID 14680956

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The first structural model of eukaryotic GluI from Saccharomyces cereveisiae determined by X-ray crystallography.
      Title: Specificity of Processing α-glucosidase I is guided by the substrate conformation: crystallographic and in silico studies.
    2. These findings indicate that the active conformation of the enzyme is not dependent on protein glycosylation and suggest that the M1-I28 region of Cwh41p carries an ER-targeting signal sequence.
      Title: Truncations and functional carboxylic acid residues of yeast processing alpha-glucosidase I.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fungal-type cell wall beta-glucan biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in fungal-type cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oligosaccharide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mannosyl-oligosaccharide glucosidase
    NP_011488.1
    • Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      443642..446143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180892.1 → NP_011488.1  TPA: mannosyl-oligosaccharide glucosidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011488.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUB1, P53008
      UniProtKB/TrEMBL
      B3LIP0, B5VIT4, N1P3P4
      Conserved Domains (2) summary
      pfam03200
      Location:319 → 832
      Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain
      pfam16923
      Location:45 → 266
      Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53008.1

    Gene LinkOut

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