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    RPN12 proteasome regulatory particle lid subunit RPN12 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850613, updated on 18-Sep-2024

    Summary

    Official Symbol
    RPN12
    Official Full Name
    proteasome regulatory particle lid subunit RPN12
    Primary source
    SGD:S000001948
    Locus tag
    YFR052W
    See related
    AllianceGenome:SGD:S000001948; FungiDB:YFR052W; VEuPathDB:YFR052W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NIN1
    Summary
    Involved in ubiquitin-dependent protein catabolic process. Located in proteasome storage granule. Part of proteasome regulatory particle, lid subcomplex. Orthologous to human PSMD8 (proteasome 26S subunit, non-ATPase 8). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See RPN12 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (252505..253329)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene proteasome core particle subunit beta 7 Neighboring gene coatomer subunit delta Neighboring gene hexokinase 1 Neighboring gene uncharacterized protein

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome regulatory particle IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome regulatory particle, lid subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome regulatory particle, lid subcomplex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in proteasome storage granule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    proteasome regulatory particle lid subunit RPN12
    NP_116710.1
    • Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      252505..253329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180017.1NP_116710.1  TPA: proteasome regulatory particle lid subunit RPN12 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116710.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTT5, P32496
      UniProtKB/TrEMBL
      A7A292, B3LUR3, B5VI77, C7GYF5, C8Z7Y7, G2WDJ3, N1PA14
      Conserved Domains (1) summary
      cl24019
      Location:122226
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family