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    SPS1 putative serine/threonine protein kinase SPS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852135, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SPS1
    Official Full Name
    putative serine/threonine protein kinase SPS1
    Primary source
    SGD:S000002931
    Locus tag
    YDR523C
    See related
    AllianceGenome:SGD:S000002931; FungiDB:YDR523C; VEuPathDB:YDR523C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein kinase activity. Involved in several processes, including ascospore wall assembly; meiotic spindle disassembly; and negative regulation of protein localization to nucleolus. Located in cytoplasm; nucleus; and prospore membrane. Orthologous to several human genes including STK26 (serine/threonine kinase 26). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SPS1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1485566..1487038, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Urc2p Neighboring gene Sps2p Neighboring gene GTPase-activating protein AGE1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutation of the SPS1-encoded protein kinase of Saccharomyces cerevisiae leads to defects in transcription and morphology during spore formation. Friesen H, et al. Genes Dev, 1994 Sep 15. PMID 7958886
    2. Characterization and mutational analysis of a cluster of three genes expressed preferentially during sporulation of Saccharomyces cerevisiae. Percival-Smith A, et al. Mol Cell Biol, 1986 Jul. PMID 3023934, Free PMC Article
    3. Meiosis II spindle disassembly requires two distinct pathways. Seitz BC, et al. Mol Biol Cell, 2023 Sep 1. PMID 37436806, Free PMC Article
    4. The GCKIII kinase Sps1 and the 14-3-3 isoforms, Bmh1 and Bmh2, cooperate to ensure proper sporulation in Saccharomyces cerevisiae. Slubowski CJ, et al. PLoS One, 2014. PMID 25409301, Free PMC Article
    5. Role of IME1 expression in regulation of meiosis in Saccharomyces cerevisiae. Smith HE, et al. Mol Cell Biol, 1990 Dec. PMID 2247050, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Noncanonical Hippo Pathway Regulates Spindle Disassembly and Cytokinesis During Meiosis in Saccharomyces cerevisiae.
      Title: A Noncanonical Hippo Pathway Regulates Spindle Disassembly and Cytokinesis During Meiosis in Saccharomyces cerevisiae.
    2. Genetic dissection of prospore membrane closure finds SPS1 and SPO77 act in parallel to a previously described pathway of prospore membrane closure that involves AMA1, an activator of the meiotic anaphase promoting complex.
      Title: Timely Closure of the Prospore Membrane Requires SPS1 and SPO77 in Saccharomyces cerevisiae.
    3. Data suggest that Sps1p promotes sporulation, in part, by regulating the intracellular movement of proteins required for spore wall formation.
      Title: Saccharomyces cerevisiae Sps1p regulates trafficking of enzymes required for spore wall synthesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ascospore formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ascospore wall assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic spindle disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to nucleolus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ascospore-type prospore membrane formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in prospore membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative serine/threonine protein kinase SPS1
    NP_010811.1
    • STE20-family GCKIII protein kinase; required for prospore membrane closure, efficient spore packaging, and localization of enzymes involved in spore wall synthesis; component of a non-canonical Hippo pathway with Cdc15p involved in spindle disassembly and sustained release of Cdc14p during anaphase II; forms a complex with Cdc15p; phosphorylation requires Cdc15p; required for Ssp1p phosphorylation and turnover; interacts with 14-3-3 proteins; expressed in late meiosis; nuclear and cytoplasmic

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1485566..1487038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180831.1 → NP_010811.1  TPA: putative serine/threonine protein kinase SPS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010811.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTE3, P08458
      UniProtKB/TrEMBL
      A6ZZA9, C7GKV4, C8Z679, G2WBP9, N1P7R6
      Conserved Domains (1) summary
      cd06609
      Location:16 → 291
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08458.2

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