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    MET32 Met32p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851840, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MET32
    Official Full Name
    Met32p
    Primary source
    SGD:S000002661
    Locus tag
    YDR253C
    See related
    AllianceGenome:SGD:S000002661; FungiDB:YDR253C; VEuPathDB:YDR253C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of mitotic cell cycle; regulation of sulfur amino acid metabolic process; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MET32 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (963990..964565, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Pam1p Neighboring gene CCR4-NOT core subunit BTT1 Neighboring gene Chl4p Neighboring gene ubiquitin-protein ligase RMD5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Microarrays and cell cycle transcription in yeast. Futcher B. Curr Opin Cell Biol, 2000 Dec. PMID 11063936
    2. The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction. Craig KL, et al. Prog Biophys Mol Biol, 1999. PMID 10581972
    3. Met31p and Met32p, two related zinc finger proteins, are involved in transcriptional regulation of yeast sulfur amino acid metabolism. Blaiseau PL, et al. Mol Cell Biol, 1997 Jul. PMID 9199298, Free PMC Article
    4. Impairment of MET transcriptional activators, MET4 and MET31 induced lipid accumulation in Saccharomyces cerevisiae. Rajakumar S, et al. FEMS Yeast Res, 2020 Aug 1. PMID 32648914
    5. Exposure of Saccharomyces cerevisiae to acetaldehyde induces sulfur amino acid metabolism and polyamine transporter genes, which depend on Met4p and Haa1p transcription factors, respectively. Aranda A, et al. Appl Environ Microbiol, 2004 Apr. PMID 15066780, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Met32 has a regulatory role as part of the Cbf1-Met4 complex as shown by the met30 cell cycle defect
      Title: A dominant suppressor mutation of the met30 cell cycle defect suggests regulation of the Saccharomyces cerevisiae Met4-Cbf1 transcription complex by Met32.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of sulfur amino acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of sulfur amino acid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of sulfur amino acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Met32p
    NP_010539.1
    • Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; feedforward loop exists in the regulation of genes controlled by Met4p and Met32p; lack of such a loop for MET31 may account for the differential actions of Met32p and Met31p; MET32 has a paralog, MET31, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      963990..964565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180561.1 → NP_010539.1  TPA: Met32p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010539.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSN3, Q12041
      UniProtKB/TrEMBL
      A6ZYK5, B3LG37, B5VGD7, C7GTI8, C8Z5G5, G2WAZ6, N1P531
      Conserved Domains (2) summary
      COG5048
      Location:41 → 191
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:100 → 120
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12041.1

    Gene LinkOut

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