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    MGR3 Mgr3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855142, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MGR3
    Official Full Name
    Mgr3p
    Primary source
    SGD:S000004721
    Locus tag
    YMR115W
    See related
    AllianceGenome:SGD:S000004721; FungiDB:YMR115W; VEuPathDB:YMR115W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FMP24
    Summary
    Enables misfolded protein binding activity. Involved in protein quality control for misfolded or incompletely synthesized proteins. Located in mitochondrial inner membrane. Part of i-AAA complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MGR3 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (497704..499209)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene dihydrofolate synthase Neighboring gene putative peptide hydrolase Neighboring gene ribosomal 40S subunit protein ASC1 Neighboring gene ncRNA Neighboring gene kinetochore-associated Ndc80 complex subunit SPC24

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial inner-membrane protease Yme1 degrades outer-membrane proteins Tom22 and Om45. Wu X, et al. J Cell Biol, 2018 Jan 2. PMID 29138251, Free PMC Article
    2. Translocation and assembly of mitochondrially coded Saccharomyces cerevisiae cytochrome c oxidase subunit Cox2 by Oxa1 and Yme1 in the absence of Cox18. Fiumera HL, et al. Genetics, 2009 Jun. PMID 19307606, Free PMC Article
    3. Mgr3p and Mgr1p are adaptors for the mitochondrial i-AAA protease complex. Dunn CD, et al. Mol Biol Cell, 2008 Dec. PMID 18843051, Free PMC Article
    4. Insertion Defects of Mitochondrially Encoded Proteins Burden the Mitochondrial Quality Control System. Vargas Möller-Hergt B, et al. Cells, 2018 Oct 17. PMID 30336542, Free PMC Article
    5. Barth syndrome mutations that cause tafazzin complex lability. Claypool SM, et al. J Cell Biol, 2011 Feb 7. PMID 21300850, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables misfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein quality control for misfolded or incompletely synthesized proteins IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of i-AAA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of i-AAA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mgr3p
    NP_013833.1
    • Subunit of the mitochondrial (mt) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      497704..499209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182615.1 → NP_013833.1  TPA: Mgr3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013833.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZT8, Q04472
      UniProtKB/TrEMBL
      G2WKG5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04472.1

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