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    MXRA5 matrix remodeling associated 5 [ Homo sapiens (human) ]

    Gene ID: 25878, updated on 28-Oct-2024

    Summary

    Official Symbol
    MXRA5provided by HGNC
    Official Full Name
    matrix remodeling associated 5provided by HGNC
    Primary source
    HGNC:HGNC:7539
    See related
    Ensembl:ENSG00000101825 MIM:300938; AllianceGenome:HGNC:7539
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes one of the matrix-remodelling associated proteins. This protein contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. This gene has a pseudogene on chromosome Y. [provided by RefSeq, Mar 2010]
    Expression
    Ubiquitous expression in skin (RPKM 16.1), urinary bladder (RPKM 11.0) and 22 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MXRA5 in Genome Data Viewer
    Location:
    Xp22.33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (3308565..3346652, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (2922161..2960959, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (3226606..3264693, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S24 pseudogene 21 Neighboring gene MPRA-validated peak7351 silencer Neighboring gene NANOG hESC enhancer GRCh37_chrX:3102859-3103394 Neighboring gene long intergenic non-protein coding RNA 1546 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:3280933-3281483 Neighboring gene argininosuccinate synthetase 1 pseudogene 4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:3445471-3446670 Neighboring gene small nucleolar RNA, H/ACA box 48B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    matrix-remodeling-associated protein 5
    Names
    adhesion protein with leucine-rich repeats and Immunoglobulin domains related to perlecan
    adlican
    matrix-remodelling associated 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021336.1 RefSeqGene

      Range
      4992..43079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_015419.4NP_056234.2  matrix-remodeling-associated protein 5 precursor

      See identical proteins and their annotated locations for NP_056234.2

      Status: REVIEWED

      Source sequence(s)
      AC004616, AF245505, BC064986, CD626974
      Consensus CDS
      CCDS14124.1
      UniProtKB/Swiss-Prot
      Q6P1M7, Q9NR99, Q9Y3Y8
      Related
      ENSP00000217939.5, ENST00000217939.7
      Conserved Domains (10) summary
      cd00096
      Location:27512824
      Ig; Immunoglobulin domain
      smart00408
      Location:19652032
      IGc2; Immunoglobulin C-2 Type
      smart00082
      Location:217263
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:25492633
      IG; Immunoglobulin
      smart00410
      Location:23562435
      IG_like; Immunoglobulin like
      pfam07679
      Location:19582042
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:3855
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:128168
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:102163
      LRR_8; Leucine rich repeat
      cl11960
      Location:23612435
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      3308565..3346652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      2922161..2960959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)