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    GRAP2 GRB2 related adaptor protein 2 [ Homo sapiens (human) ]

    Gene ID: 9402, updated on 2-Nov-2024

    Summary

    Official Symbol
    GRAP2provided by HGNC
    Official Full Name
    GRB2 related adaptor protein 2provided by HGNC
    Primary source
    HGNC:HGNC:4563
    See related
    Ensembl:ENSG00000100351 MIM:604518; AllianceGenome:HGNC:4563
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P38; GADS; GRID; GRPL; GrbX; Mona; GRB2L; GRBLG; Grf40; GRAP-2
    Summary
    This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
    Expression
    Broad expression in lymph node (RPKM 6.7), spleen (RPKM 4.1) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
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    Genomic context

    See GRAP2 in Genome Data Viewer
    Location:
    22q13.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (39893820..39973721)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (40364806..40444710)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (40297088..40369725)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ENTH domain containing 1 Neighboring gene RN7SK pseudogene 210 Neighboring gene ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19075 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr22:40328916-40329580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:40335123-40335875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19076 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:40355047-40355548 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:40361232-40361409 Neighboring gene uncharacterized LOC124905155 Neighboring gene translation machinery associated 7 homolog B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:40390673-40391306 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:40393419-40394024 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:40394025-40394630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:40401347-40401848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:40401849-40402348 Neighboring gene family with sequence similarity 83 member F Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:40418684-40419184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:40419185-40419685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19079 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:40426725-40427244 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:40439529-40440176 Neighboring gene TNRC6B divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    GRB2-related adapter protein 2
    Names
    GRB-2-like protein
    GRB2-related protein with insert domain
    SH3-SH2-SH3 adapter Mona
    SH3-SH2-SH3 adaptor molecule
    adapter protein GRID
    grf-40
    grf40 adapter protein
    growth factor receptor-binding protein
    growth factor receptor-bound protein 2-related adaptor protein 2
    hematopoietic cell-associated adapter protein GrpL
    hematopoietic cell-associated adaptor protein GRPL

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291824.2NP_001278753.1  GRB2-related adapter protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001278753.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 2 and 3 encode the same isoform.
      Source sequence(s)
      AK312830, DC409651, KF457461, Z82206
      Consensus CDS
      CCDS13999.1
      UniProtKB/Swiss-Prot
      B7Z8I3, O43726, O75791, Q9NRB7
      UniProtKB/TrEMBL
      Q6FHA6, Q6FI14
      Conserved Domains (3) summary
      cd09941
      Location:54147
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11947
      Location:253
      SH3_GRAP2_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein 2
      cd11950
      Location:275327
      SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
    2. NM_001291825.1NP_001278754.1  GRB2-related adapter protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001278754.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform 1.
      Source sequence(s)
      AF236120, Z82206
      Consensus CDS
      CCDS13999.1
      UniProtKB/Swiss-Prot
      B7Z8I3, O43726, O75791, Q9NRB7
      UniProtKB/TrEMBL
      Q6FHA6, Q6FI14
      Related
      ENSP00000385607.3, ENST00000407075.3
      Conserved Domains (3) summary
      cd09941
      Location:54147
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11947
      Location:253
      SH3_GRAP2_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein 2
      cd11950
      Location:275327
      SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
    3. NM_001291826.2NP_001278755.1  GRB2-related adapter protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001278755.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an internal exon, which results in a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK303280, DC409651, KF457461, Z82206
      UniProtKB/TrEMBL
      B7Z8E3, B7Z8J2
      Conserved Domains (2) summary
      cd09941
      Location:375
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11950
      Location:203255
      SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
    4. NM_001291828.2NP_001278757.1  GRB2-related adapter protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001278757.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks three internal exons, which results in an alternate downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK303470, HY091328, KF457461, Z82206
      UniProtKB/Swiss-Prot
      O75791
      Conserved Domains (1) summary
      cd11950
      Location:162214
      SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
    5. NM_004810.4NP_004801.1  GRB2-related adapter protein 2 isoform 1

      See identical proteins and their annotated locations for NP_004801.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform 1.
      Source sequence(s)
      AY069959, KF457461, Z82206
      Consensus CDS
      CCDS13999.1
      UniProtKB/Swiss-Prot
      B7Z8I3, O43726, O75791, Q9NRB7
      UniProtKB/TrEMBL
      Q6FHA6, Q6FI14
      Related
      ENSP00000339186.4, ENST00000344138.9
      Conserved Domains (3) summary
      cd09941
      Location:54147
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11947
      Location:253
      SH3_GRAP2_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein 2
      cd11950
      Location:275327
      SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      39893820..39973721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441607.1XP_047297563.1  GRB2-related adapter protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B7Z8I3, O43726, O75791, Q9NRB7
      UniProtKB/TrEMBL
      Q6FI14
    2. XM_047441608.1XP_047297564.1  GRB2-related adapter protein 2 isoform X2

      UniProtKB/TrEMBL
      B7Z8F8

    RNA

    1. XR_007067995.1 RNA Sequence

    2. XR_007067996.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      40364806..40444710
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326139.1XP_054182114.1  GRB2-related adapter protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B7Z8I3, O43726, O75791, Q9NRB7
      UniProtKB/TrEMBL
      Q6FI14
    2. XM_054326140.1XP_054182115.1  GRB2-related adapter protein 2 isoform X2

      UniProtKB/TrEMBL
      B7Z8F8

    RNA

    1. XR_008485437.1 RNA Sequence

    2. XR_008485438.1 RNA Sequence