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    Taok2 TAO kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 381921, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Taok2provided by MGI
    Official Full Name
    TAO kinase 2provided by MGI
    Primary source
    MGI:MGI:1915919
    See related
    Ensembl:ENSMUSG00000059981 AllianceGenome:MGI:1915919
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PSK; PSK1; TAO1; TAO2; MAP3K17; mKIAA0881; B230344N16; 1110033K02Rik
    Summary
    Enables neuropilin binding activity. Involved in neuron projection morphogenesis; positive regulation of JNK cascade; and regulation of actin cytoskeleton organization. Located in axonal growth cone and dendritic growth cone. Colocalizes with actin cytoskeleton. Is expressed in central nervous system and retina. Orthologous to human TAOK2 (TAO kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 32.8), ovary adult (RPKM 27.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Taok2 in Genome Data Viewer
    Location:
    7 F3; 7 69.25 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126464848..126485468, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126865674..126886296, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene double C2, alpha Neighboring gene INO80 complex subunit E Neighboring gene STARR-positive B cell enhancer ABC_E8843 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134005673-134005856 Neighboring gene HIRA interacting protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E2849 Neighboring gene transmembrane protein 219 Neighboring gene predicted gene, 23445 Neighboring gene STARR-positive B cell enhancer ABC_E10477 Neighboring gene potassium channel tetramerisation domain containing 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model. Scharrenberg R, et al. Mol Psychiatry, 2022 Nov. PMID 36123424, Free PMC Article
    2. Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling. Richter M, et al. Mol Psychiatry, 2019 Sep. PMID 29467497, Free PMC Article
    3. The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation. Henis M, et al. Sci Adv, 2024 Apr 12. PMID 38608030, Free PMC Article
    4. Taok2 controls behavioral response to ethanol in mice. Kapfhamer D, et al. Genes Brain Behav, 2013 Feb. PMID 22883308, Free PMC Article
    5. Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex. de Anda FC, et al. Nat Neurosci, 2012 Jun 10. PMID 22683681, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model.
      Title: TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model.
    2. disruption of the Taok2 gene alters behavioral response to ethanol.
      Title: Taok2 controls behavioral response to ethanol in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation
    • Transgenic (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0881

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MAP kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neuropilin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables neuropilin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in axonogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in basal dendrite arborization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in basal dendrite arborization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in basal dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in basal dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in focal adhesion assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress-activated MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic membrane adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress-activated MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase TAO2
    Names
    TAO kinase 2TAO kinase 2
    thousand and one amino acid protein 2
    NP_001157246.1
    NP_001157247.1
    XP_030098581.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163774.2 → NP_001157246.1  serine/threonine-protein kinase TAO2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 2. The resulting isoform (1) has a shorter and distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AC122863, AC124505
      Consensus CDS
      CCDS52404.1
      UniProtKB/Swiss-Prot
      Q6ZQ29
      Related
      ENSMUSP00000071246.5, ENSMUST00000071268.11
      Conserved Domains (2) summary
      COG0419
      Location:481 → 920
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06634
      Location:12 → 319
      STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2

    2. NM_001163775.2 → NP_001157247.1  serine/threonine-protein kinase TAO2 isoform 2

      See identical proteins and their annotated locations for NP_001157247.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AC122863, AC124505
      Consensus CDS
      CCDS52403.1
      UniProtKB/Swiss-Prot
      Q6ZQ29, Q7TSS8
      Related
      ENSMUSP00000112963.2, ENSMUST00000117394.2
      Conserved Domains (2) summary
      smart00220
      Location:28 → 281
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06634
      Location:12 → 319
      STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126464848..126485468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242721.2 → XP_030098581.1  serine/threonine-protein kinase TAO2 isoform X1

      Conserved Domains (2) summary
      COG0419
      Location:481 → 920
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06634
      Location:12 → 319
      STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2

    RNA

    1. XR_001785578.3 RNA Sequence

    2. XR_003946498.1 RNA Sequence

    3. XR_001785580.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZQ29.3 GenPept UniProtKB/Swiss-Prot:Q6ZQ29

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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