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    Rgs3 regulator of G-protein signaling 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54293, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rgs3provided by RGD
    Official Full Name
    regulator of G-protein signaling 3provided by RGD
    Primary source
    RGD:3566
    See related
    EnsemblRapid:ENSRNOG00000024501 AllianceGenome:RGD:3566
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SRB-RGS
    Summary
    Predicted to enable GTPase regulator activity. Predicted to be involved in negative regulation of signal transduction. Predicted to be located in cytoplasm. Predicted to be active in nucleus and plasma membrane. Biomarker of bladder disease and lesion of sciatic nerve. Orthologous to human RGS3 (regulator of G protein signaling 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 61.3), Heart (RPKM 37.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rgs3 in Genome Data Viewer
    Location:
    5q24
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (81037588..81177446)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (76022038..76161895)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (78429017..78567281)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L31-like Neighboring gene similar to human chromosome 9 open reading frame 43 Neighboring gene DNA polymerase epsilon 3, accessory subunit Neighboring gene ubiquitin C-terminal hydrolase L3, pseudogene 2 Neighboring gene uncharacterized LOC120102895 Neighboring gene uncharacterized LOC120102896

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization and identification of a steroid receptor-binding protein, SRB-RGS. Ikeda M, et al. Biol Pharm Bull, 2007 Jun. PMID 17541154
    2. Molecular cloning and characterization of a steroid receptor-binding regulator of G-protein signaling protein cDNA. Ikeda M, et al. Gene, 2001 Aug 8. PMID 11595167
    3. High basal expression and injury-induced down regulation of two regulator of G-protein signaling transcripts, RGS3 and RGS4 in primary sensory neurons. Costigan M, et al. Mol Cell Neurosci, 2003 Sep. PMID 14550772
    4. Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells. Wang Q, et al. J Biol Chem, 2002 Jul 12. PMID 12006602
    5. Natriuretic peptides inhibit G protein activation. Mediation through cross-talk between cyclic GMP-dependent protein kinase and regulators of G protein-signaling proteins. Pedram A, et al. J Biol Chem, 2000 Mar 10. PMID 10702309

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SRB-RGS was characterized and identified as a steroid receptor-binding protein.
      Title: Characterization and identification of a steroid receptor-binding protein, SRB-RGS.
    2. role in regulating mitogen-activated protein kinase activation in rat vascular smooth muscle cells
      Title: Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells.
    3. cell surface expression and regulation of GnRHR bearing a carboxyl-terminus is altered by RGS10, but not by RGS3, proteins
      Title: Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: role of the GnRHR carboxyl-terminus.
    4. RGS3 is expressed at high levels in C-fiber primary sensory neurons in the adult rat dorsal root ganglion (DRG) and sciatic nerve transection results in a downregulation of this transcript.
      Title: High basal expression and injury-induced down regulation of two regulator of G-protein signaling transcripts, RGS3 and RGS4 in primary sensory neurons.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93233

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 3
    Names
    regulator of G-protein signalling 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429681.1 → NP_001416610.1  regulator of G-protein signaling 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5ZT37

    2. NM_019340.2 → NP_062213.2  regulator of G-protein signaling 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6J7W3, G3V9Q2
      Related
      ENSRNOP00000055956.4, ENSRNOT00000059183.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      81037588..81177446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288323.1 → XP_063144393.1  regulator of G-protein signaling 3 isoform X6

      UniProtKB/TrEMBL
      A0A8L2QRC0, A6J7W2
      Related
      ENSRNOP00000055954.4, ENSRNOT00000059181.6

    2. XM_063288324.1 → XP_063144394.1  regulator of G-protein signaling 3 isoform X8

    3. XM_039110674.2 → XP_038966602.1  regulator of G-protein signaling 3 isoform X1

      UniProtKB/Swiss-Prot
      P49797, Q5RKK6, Q920Q9
      UniProtKB/TrEMBL
      A0A0G2K1B5
      Conserved Domains (4) summary
      cd08685
      Location:35 → 154
      C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
      cd08713
      Location:1020 → 1133
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      PHA03307
      Location:578 → 802
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:195 → 268
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    4. XM_063288322.1 → XP_063144392.1  regulator of G-protein signaling 3 isoform X2

    5. XM_017593595.2 → XP_017449084.1  regulator of G-protein signaling 3 isoform X1

      UniProtKB/Swiss-Prot
      P49797, Q5RKK6, Q920Q9
      UniProtKB/TrEMBL
      A0A0G2K1B5
      Related
      ENSRNOP00000071774.1, ENSRNOT00000080744.3
      Conserved Domains (4) summary
      cd08685
      Location:35 → 154
      C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
      cd08713
      Location:1020 → 1133
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      PHA03307
      Location:578 → 802
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:195 → 268
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    6. XM_006238260.5 → XP_006238322.1  regulator of G-protein signaling 3 isoform X3

      Related
      ENSRNOP00000081496.1, ENSRNOT00000107343.2
      Conserved Domains (7) summary
      cd08685
      Location:27 → 146
      C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
      cd08713
      Location:1012 → 1125
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      COG0265
      Location:207 → 262
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:187 → 260
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09786
      Location:581 → 788
      CytochromB561_N; Cytochrome B561, N terminal
      pfam16228
      Location:531 → 706
      DUF4887; Domain of unknown function (DUF4887)
      cl09930
      Location:565 → 627
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

    7. XM_006238264.5 → XP_006238326.1  regulator of G-protein signaling 3 isoform X7

      Conserved Domains (2) summary
      cd08685
      Location:27 → 146
      C2_RGS-like; C2 domain of the Regulator Of G-Protein Signaling (RGS) family
      cd00992
      Location:187 → 260
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    8. XM_017593597.3 → XP_017449086.1  regulator of G-protein signaling 3 isoform X4

      UniProtKB/Swiss-Prot
      P49797, Q5RKK6, Q920Q9

    9. XM_039110676.2 → XP_038966604.1  regulator of G-protein signaling 3 isoform X5

      UniProtKB/Swiss-Prot
      P49797, Q5RKK6, Q920Q9
      Conserved Domains (4) summary
      cd08713
      Location:887 → 1000
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      PHA03307
      Location:445 → 669
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:62 → 135
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl14603
      Location:1 → 21
      C2; C2 domain

    10. XM_006238265.5 → XP_006238327.1  regulator of G-protein signaling 3 isoform X10

      See identical proteins and their annotated locations for XP_006238327.1

      UniProtKB/Swiss-Prot
      P49797
      Conserved Domains (2) summary
      COG0265
      Location:38 → 93
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:17 → 91
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    11. XM_063288325.1 → XP_063144395.1  regulator of G-protein signaling 3 isoform X9

      UniProtKB/TrEMBL
      A6J7W4

    12. XM_008763801.4 → XP_008762023.1  regulator of G-protein signaling 3 isoform X9

      See identical proteins and their annotated locations for XP_008762023.1

      UniProtKB/TrEMBL
      A6J7W4
      Conserved Domains (2) summary
      cd08713
      Location:445 → 558
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      PHA03307
      Location:3 → 227
      PHA03307; transcriptional regulator ICP4; Provisional

    13. XM_008763802.4 → XP_008762024.1  regulator of G-protein signaling 3 isoform X9

      See identical proteins and their annotated locations for XP_008762024.1

      UniProtKB/TrEMBL
      A6J7W4
      Conserved Domains (2) summary
      cd08713
      Location:445 → 558
      RGS_RGS3; Regulator of G protein signaling (RGS) domain found in the RGS3 protein
      PHA03307
      Location:3 → 227
      PHA03307; transcriptional regulator ICP4; Provisional

    14. XM_063288326.1 → XP_063144396.1  regulator of G-protein signaling 3 isoform X9

      UniProtKB/TrEMBL
      A6J7W4

    15. XM_063288327.1 → XP_063144397.1  regulator of G-protein signaling 3 isoform X11

      UniProtKB/TrEMBL
      A0A8I6AJG0
      Related
      ENSRNOP00000093735.1, ENSRNOT00000099793.2

    16. XM_063288328.1 → XP_063144398.1  regulator of G-protein signaling 3 isoform X12

      UniProtKB/TrEMBL
      A6J7W5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49797.2 GenPept UniProtKB/Swiss-Prot:P49797

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