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    Fbxo6 F-box protein 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192351, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fbxo6provided by RGD
    Official Full Name
    F-box protein 6provided by RGD
    Primary source
    RGD:620418
    See related
    EnsemblRapid:ENSRNOG00000009217 AllianceGenome:RGD:620418
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fbg2; Fbxo6b
    Summary
    Predicted to enable carbohydrate binding activity. Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and glycoprotein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in endoplasmic reticulum quality control compartment. Orthologous to human FBXO6 (F-box protein 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 233.8), Heart (RPKM 218.5) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxo6 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (163859909..163865693, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (158576729..158582520, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (164956285..164962075, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene dorsal inhibitory axon guidance protein Neighboring gene ribosomal protein L35A, pseudogene 7 Neighboring gene mitotic arrest deficient 2 like 2 Neighboring gene F-box protein 44 Neighboring gene F-box protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. Zhang YW, et al. Mol Cell, 2009 Aug 28. PMID 19716789, Free PMC Article
    2. A new subfamily of structurally related human F-box proteins. Ilyin GP, et al. Gene, 2002 Aug 21. PMID 12383498
    3. Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains. Yoshida Y, et al. J Biol Chem, 2003 Oct 31. PMID 12939278
    4. Glycoprotein-specific ubiquitin ligases recognize N-glycans in unfolded substrates. Yoshida Y, et al. EMBO Rep, 2005 Mar. PMID 15723043, Free PMC Article
    5. Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulum-associated degradation steps. Groisman B, et al. J Biol Chem, 2011 Jan 14. PMID 21062743, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycoprotein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glycoprotein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum quality control compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum quality control compartment ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 6
    Names
    F-box only protein 6 b
    F-box only protein 6b
    F-box protein that recognizes sugar chains 2
    F-box/G-domain protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138917.3 → NP_620272.3  F-box only protein 6

      See identical proteins and their annotated locations for NP_620272.3

      Status: PROVISIONAL

      Source sequence(s)
      AF393484
      UniProtKB/Swiss-Prot
      Q6P512, Q923V4
      UniProtKB/TrEMBL
      A6IU51
      Conserved Domains (2) summary
      pfam04300
      Location:70 → 248
      FBA; F-box associated region
      pfam12937
      Location:4 → 51
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      163859909..163865693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239374.5 → XP_006239436.1  F-box only protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006239436.1

      UniProtKB/Swiss-Prot
      Q6P512, Q923V4
      UniProtKB/TrEMBL
      A6IU51
      Related
      ENSRNOP00000012301.4, ENSRNOT00000012301.6
      Conserved Domains (2) summary
      pfam04300
      Location:70 → 248
      FBA; F-box associated region
      pfam12937
      Location:4 → 51
      F-box-like; F-box-like

    2. XM_006239375.5 → XP_006239437.1  F-box only protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006239437.1

      UniProtKB/Swiss-Prot
      Q6P512, Q923V4
      UniProtKB/TrEMBL
      A6IU51
      Conserved Domains (2) summary
      pfam04300
      Location:70 → 248
      FBA; F-box associated region
      pfam12937
      Location:4 → 51
      F-box-like; F-box-like

    3. XM_006239372.5 → XP_006239434.1  F-box only protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006239434.1

      UniProtKB/Swiss-Prot
      Q6P512, Q923V4
      UniProtKB/TrEMBL
      A6IU51
      Conserved Domains (2) summary
      pfam04300
      Location:70 → 248
      FBA; F-box associated region
      pfam12937
      Location:4 → 51
      F-box-like; F-box-like

    4. XM_006239373.5 → XP_006239435.1  F-box only protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006239435.1

      UniProtKB/Swiss-Prot
      Q6P512, Q923V4
      UniProtKB/TrEMBL
      A6IU51
      Conserved Domains (2) summary
      pfam04300
      Location:70 → 248
      FBA; F-box associated region
      pfam12937
      Location:4 → 51
      F-box-like; F-box-like

    5. XM_063287150.1 → XP_063143220.1  F-box only protein 6 isoform X1

      UniProtKB/Swiss-Prot
      Q6P512, Q923V4
      UniProtKB/TrEMBL
      A6IU51
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q923V4.1 GenPept UniProtKB/Swiss-Prot:Q923V4

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