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    Bphl biphenyl hydrolase like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361239, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Bphlprovided by RGD
    Official Full Name
    biphenyl hydrolase likeprovided by RGD
    Primary source
    RGD:1307572
    See related
    EnsemblRapid:ENSRNOG00000017577 AllianceGenome:RGD:1307572
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable alpha-amino-acid esterase activity and poly(ADP-ribose) glycohydrolase activity. Predicted to be involved in ATP generation from poly-ADP-D-ribose. Predicted to be located in cytosol; mitochondrion; and nuclear body. Orthologous to human BPHL (biphenyl hydrolase like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 355.4), Liver (RPKM 179.6) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bphl in Genome Data Viewer
    Location:
    17p12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (31006283..31042631, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (30800939..30837277, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (31498877..31535172, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene tubulin, beta 2A class IIa like 1 Neighboring gene tubulin, beta 2A class IIa Neighboring gene receptor interacting serine/threonine kinase 1 Neighboring gene serpin family B member 6A Neighboring gene N-ribosyldihydronicotinamide:quinone dehydrogenase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A nonradiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): application to inhibitor identification and evaluation. Putt KS, et al. Anal Biochem, 2004 Oct 15. PMID 15450800
    2. Analysis of poly(ADP-ribose) glycohydrolase activity in nuclear extracts from mammalian cells. Bernardi R, et al. Biochim Biophys Acta, 1997 Mar 7. PMID 9074616
    3. ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling. Wright RH, et al. Science, 2016 Jun 3. PMID 27257257
    4. Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases. Rosenthal F, et al. Nat Struct Mol Biol, 2013 Apr. PMID 23474714
    5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125077

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-amino-acid esterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(ADP-ribose) glycohydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP generation from poly-ADP-D-ribose ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    valacyclovir hydrolase
    Names
    biphenyl hydrolase-like (serine hydrolase)
    biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037206.1 → NP_001032283.1  valacyclovir hydrolase

      See identical proteins and their annotated locations for NP_001032283.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105908
      UniProtKB/TrEMBL
      F7FBS0, Q3B8N9
      Related
      ENSRNOP00000023914.6, ENSRNOT00000023914.8
      Conserved Domains (1) summary
      COG0596
      Location:44 → 291
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      31006283..31042631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276588.1 → XP_063132658.1  valacyclovir hydrolase isoform X4

    2. XM_063276586.1 → XP_063132656.1  valacyclovir hydrolase isoform X1

    3. XM_039095883.1 → XP_038951811.1  valacyclovir hydrolase isoform X3

      UniProtKB/TrEMBL
      A6J7G9
      Conserved Domains (1) summary
      COG0596
      Location:25 → 189
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    4. XM_063276587.1 → XP_063132657.1  valacyclovir hydrolase isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.