Fdft1 farnesyl diphosphate farnesyl transferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fdft1provided by RGD
Official Full Name: farnesyl diphosphate farnesyl transferase 1provided by RGD
Primary source: RGD:61834
See related: EnsemblRapid:ENSRNOG00000021314 AllianceGenome:RGD:61834
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables squalene synthase [NAD(P)H] activity. Involved in cholesterol biosynthetic process and farnesyl diphosphate metabolic process. Located in endoplasmic reticulum membrane. Used to study cataract. Orthologous to human FDFT1 (farnesyl-diphosphate farnesyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 258.9), Kidney (RPKM 209.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (41588114..41616168, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (37412143..37440198, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (46339248..46367302, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protective mechanism of fdft1 in steroid hormone synthesis pathway in SD rats with acute hypoxic injury.
Title: Protective mechanism of fdft1 in steroid hormone synthesis pathway in SD rats with acute hypoxic injury.
The hypomorphic Lss(S) and Fdft1(S) alleles are not specific to the SCR strain, but are widely prevalent in several other laboratory rat strains.
Title: Functional polymorphisms of the Lss and Fdft1 genes in laboratory rats.

Submit: New GeneRIF Correction

General gene information

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Markers

AI176781 (e-PCR)
- UniSTS:260873

RH133832 (e-PCR)
- UniSTS:217115

RH128506 (e-PCR)
- UniSTS:211814

BE105722 (e-PCR)
- UniSTS:245896

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables squalene synthase [NAD(P)H] activity	IBA Inferred from Biological aspect of Ancestor more info
enables squalene synthase [NAD(P)H] activity	IDA Inferred from Direct Assay more info	PubMed
enables squalene synthase [NAD(P)H] activity	IEA Inferred from Electronic Annotation more info
enables squalene synthase [NAD(P)H] activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cholesterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in farnesyl diphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in farnesyl diphosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in farnesyl diphosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in isoprenoid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lipid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: squalene synthase

Names: FPP:FPP farnesyltransferase; SQS; SS; farnesyl diphosphate farnesyltransferase; squalene synthetase

NP_062111.1

EC 2.5.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.