Slc11a2 solute carrier family 11 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc11a2provided by RGD
Official Full Name: solute carrier family 11 member 2provided by RGD
Primary source: RGD:3684
See related: EnsemblRapid:ENSRNOG00000019550 AllianceGenome:RGD:3684
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dmt1; Nramp2
Summary: Enables lead ion transmembrane transporter activity; transition metal ion binding activity; and transition metal ion transmembrane transporter activity. Involved in several processes, including cellular response to hypoxia; cellular response to tumor necrosis factor; and transition metal ion transport. Located in apical part of cell; late endosome membrane; and lysosomal membrane. Used to study Parkinsonism; hypochromic anemia; and pneumonia. Biomarker of brain ischemia; duodenal ulcer; and iron deficiency anemia. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; anemia; and hypochromic anemia. Orthologous to human SLC11A2 (solute carrier family 11 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 243.2), Thymus (RPKM 197.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (133381878..133429921, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (131503076..131540246, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (142025812..142062892, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HMGB1 Mediates Inflammation-Induced DMT1 Increase and Dopaminergic Neurodegeneration in the Early Stage of Parkinsonism.
Title: HMGB1 Mediates Inflammation-Induced DMT1 Increase and Dopaminergic Neurodegeneration in the Early Stage of Parkinsonism.
The Endolysosomal Transporter DMT1 is Required for Morphine Regulation of Neuronal Ferritin Heavy Chain.
Title: The Endolysosomal Transporter DMT1 is Required for Morphine Regulation of Neuronal Ferritin Heavy Chain.
DMT1 mediates mitochondrial Fe2+ and Mn2+ acquisition.
Title: A role for divalent metal transporter (DMT1) in mitochondrial uptake of iron and manganese.
impaired intestinal expression of Dcyt-b and DMT-1 might be associated with the reduction of an iron uptake in CKD. Taken together, impaired these intestinal iron transporters may become a novel therapeutic target for cardio-renal anemia syndrome.
Title: Altered expression of intestinal duodenal cytochrome b and divalent metal transporter 1 might be associated with cardio-renal anemia syndrome.
Mutations in the divalent metal transporter 1 (DMT1) decrease body iron status and up-regulate copper absorption
Title: Loss of divalent metal transporter 1 function promotes brain copper accumulation and increases impulsivity.
DMT1 and FPN1 are positively influenced by ferrous iron status in brain after intracerebral hemorrhage. DMT1 and FPN1 attenuate iron overload after ICH via increasing transmembrane iron export.
Title: Changes of ferrous iron and its transporters after intracerebral hemorrhage in rats.
work unveils the role of DMT1 in mediating the neuroregenerative action of iron.
Title: DMT1 iron uptake in the PNS: bridging the gap between injury and regeneration.
These results suggest that the genetic ablation of iPLA2b increased iron uptake in the brain through the activation of IRP2 and upregulation of DMT1, which may be associated with mitochondrial dysfunction.
Title: Deficiency of Calcium-Independent Phospholipase A2 Beta Induces Brain Iron Accumulation through Upregulation of Divalent Metal Transporter 1.
the effects of hepcidin expression and hepcidin peptide on brain iron contents, iron transport across the brain-blood barrier, iron uptake and release, and also the expression of TfR1, DMT1, and Fpn, were investigated.
Title: Hepcidin Suppresses Brain Iron Accumulation by Downregulating Iron Transport Proteins in Iron-Overloaded Rats.
DMT1 expression was enhanced in the bone tissue of type 2 diabetic rats, and plays an important role in the pathological process of diabetic osteoporosis.
Title: Regulation of DMT1 on Bone Microstructure in Type 2 Diabetes.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Wox41 (e-PCR)
- UniSTS:239387

RH129811 (e-PCR)
- UniSTS:213100

RH94425 (e-PCR)
- UniSTS:119673

AI011296 (e-PCR)
- UniSTS:250014

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cadmium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadmium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables cadmium ion binding	IEA Inferred from Electronic Annotation more info
enables cadmium ion binding	ISO Inferred from Sequence Orthology more info
enables cadmium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables cadmium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables cadmium ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables cadmium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
NOT enables calcium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
NOT enables chromium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables cobalt ion binding	IDA Inferred from Direct Assay more info	PubMed
enables cobalt ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables cobalt ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables cobalt ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables cobalt ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables copper ion binding	IDA Inferred from Direct Assay more info	PubMed
enables copper ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables copper ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables copper ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ferrous iron transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ferrous iron transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables ferrous iron transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ferrous iron transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ferrous iron transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables inorganic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IDA Inferred from Direct Assay more info	PubMed
enables iron ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables lead ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lead ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables lead ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables lead ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	IDA Inferred from Direct Assay more info	PubMed
enables manganese ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables manganese ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables manganese ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables manganese ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nickel cation binding	IDA Inferred from Direct Assay more info	PubMed
enables nickel cation transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nickel cation transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables nickel cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables retromer complex binding	ISO Inferred from Sequence Orthology more info
enables solute:proton symporter activity	IEA Inferred from Electronic Annotation more info
enables solute:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables transition metal ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables transition metal ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables vanadium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in cadmium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in cadmium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to iron ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cobalt ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cobalt ion transport	ISO Inferred from Sequence Orthology more info
involved_in cobalt ion transport	ISO Inferred from Sequence Orthology more info
involved_in copper ion import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in copper ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in copper ion transport	ISO Inferred from Sequence Orthology more info
involved_in dendrite morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
NOT involved_in detection of oxygen	ISO Inferred from Sequence Orthology more info
involved_in detection of oxygen	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in heme biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heme biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in iron import into cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within iron import into cell	ISO Inferred from Sequence Orthology more info
involved_in iron import into cell	ISO Inferred from Sequence Orthology more info
involved_in iron ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in iron ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info
involved_in iron ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within iron ion transport	ISO Inferred from Sequence Orthology more info
involved_in iron ion transport	ISO Inferred from Sequence Orthology more info
involved_in iron ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in lead ion transport	IEA Inferred from Electronic Annotation more info
involved_in lead ion transport	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
involved_in manganese ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in manganese ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in manganese ion transport	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level iron ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in nickel cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in nickel cation transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within porphyrin-containing compound biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within porphyrin-containing compound metabolic process	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to iron ion	IEA Inferred from Electronic Annotation more info
involved_in response to iron ion	IEP Inferred from Expression Pattern more info	PubMed
NOT involved_in response to iron ion	ISO Inferred from Sequence Orthology more info
involved_in response to iron ion	ISO Inferred from Sequence Orthology more info
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to manganese ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to manganese ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transition metal ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in vanadium ion transport	IEA Inferred from Electronic Annotation more info
involved_in vanadium ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal part of cell	IEA Inferred from Electronic Annotation more info
located_in basal part of cell	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular vesicle	IEA Inferred from Electronic Annotation more info
located_in extracellular vesicle	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of paraferritin complex	IEA Inferred from Electronic Annotation more info
part_of paraferritin complex	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in vacuole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: natural resistance-associated macrophage protein 2

Names: DMT-1; NRAMP 2; Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2); divalent cation transporter 1; divalent metal transporter 1; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399169.1 → NP_001386098.1 natural resistance-associated macrophage protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I6ABD7, A6KCJ0

Related

ENSRNOP00000091312.1, ENSRNOT00000093762.2

Conserved Domains (1) summary

TIGR01197
Location:68 → 467

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
NM_013173.2 → NP_037305.2 natural resistance-associated macrophage protein 2 isoform 1

See identical proteins and their annotated locations for NP_037305.2

Status: VALIDATED

Source sequence(s)

AF008439

UniProtKB/TrEMBL

A0A140TAD8, A6KCJ3, A6KCJ4

Related

ENSRNOP00000026531.6, ENSRNOT00000026531.8

Conserved Domains (2) summary

TIGR01197
Location:99 → 498

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

pfam01566
Location:121 → 504

Nramp; Natural resistance-associated macrophage protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

133381878..133429921 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263061.1 → XP_063119131.1 natural resistance-associated macrophage protein 2 isoform X1
XM_006242309.5 → XP_006242371.1 natural resistance-associated macrophage protein 2 isoform X2

See identical proteins and their annotated locations for XP_006242371.1

UniProtKB/Swiss-Prot

O35172, O54902

UniProtKB/TrEMBL

A6KCI9

Related

ENSRNOP00000068533.1, ENSRNOT00000089912.3

Conserved Domains (2) summary

TIGR01197
Location:99 → 498

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

pfam01566
Location:121 → 504

Nramp; Natural resistance-associated macrophage protein
XM_006242312.5 → XP_006242374.1 natural resistance-associated macrophage protein 2 isoform X3

See identical proteins and their annotated locations for XP_006242374.1

UniProtKB/Swiss-Prot

O35172, O54902

UniProtKB/TrEMBL

A0A8I6ABD7, A6KCJ0

Conserved Domains (1) summary

TIGR01197
Location:68 → 467

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters