Ahsg alpha-2-HS-glycoprotein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ahsgprovided by RGD
Official Full Name: alpha-2-HS-glycoproteinprovided by RGD
Primary source: RGD:2075
See related: EnsemblRapid:ENSRNOG00000038370 AllianceGenome:RGD:2075
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BSP; pp63; Aa2-066
Summary: Enables receptor signaling protein tyrosine kinase inhibitor activity. Involved in several processes, including negative regulation of bone mineralization; negative regulation of insulin receptor signaling pathway; and positive regulation of bone resorption. Located in collagen-containing extracellular matrix and extracellular space. Part of protein-containing complex. Human ortholog(s) of this gene implicated in alopecia-mental retardation syndrome 1; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human AHSG (alpha 2-HS glycoprotein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 58470.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (91625975..91632583, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (78121388..78127998, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (81711269..81717594, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fetuin-A Deficiency but Not Pentraxin 3, FGF-21, or Irisin, Predisposes to More Serious COVID-19 Course.
Title: Fetuin-A Deficiency but Not Pentraxin 3, FGF-21, or Irisin, Predisposes to More Serious COVID-19 Course.
Fetuin-A exerts the stimulatory effects on inflammatory responses in HUVECs, macrophage foam cell formation, and proliferation and collagen production in HASMCs, leading to the development of atherosclerosis.
Title: Facilitatory effects of fetuin-A on atherosclerosis.
The protective effects of pioglitazone on lipotoxicity in beta cells may involve the inhibition of the activation of the Fetuin A and TLR4 signaling pathway.
Title: Fetuin A promotes lipotoxicity in β cells through the TLR4 signaling pathway and the role of pioglitazone in anti-lipotoxicity.
Plasma levels of the calcification inhibitor fetuin-A were significantly decreased in CKD animals compared to controls.
Title: Chronic kidney disease results in deficiency of ABCC6, the novel inhibitor of vascular calcification.
We conclude that elevated fetuin-A levels are associated with microalbuminuria in obese rats, and abnormal albuminuria is reversible by improving hepatic steatosis.
Title: Serum fetuin-A levels related with microalbuminuria in diet-induced obese rats.
Fetuin-A was found in cortex, white matter, subplate, hippocampus, subventricular zone, & ependymal cells which supports a global role for brain function. It decreased with age.
Title: Fetuin-a in the developing brain.
Tubular luminal fetuin-A works as a natural inhibitor against calcification in the proximal tubules under parathyroid hormone-loaded condition.
Title: Retention of fetuin-A in renal tubular lumen protects the kidney from nephrocalcinosis in rats.
This protein may prevent glucose toxicity in cardiomyocates in the presence of insulin.
Title: alpha2-Heremans Schmid glycoprotein, a putative inhibitor of tyrosine kinase, prevents glucose toxicity associated with cardiomyocyte dysfunction.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase inhibitor activity	NAS Non-traceable Author Statement more info	PubMed
enables receptor signaling protein tyrosine kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in acute-phase response	IBA Inferred from Biological aspect of Ancestor more info
involved_in acute-phase response	ISO Inferred from Sequence Orthology more info
involved_in acute-phase response	ISS Inferred from Sequence or Structural Similarity more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of bone mineralization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ossification	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein-containing complex assembly	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: alpha-2-HS-glycoprotein

Names: 59 kDa bone sialic acid-containing protein; alpha 2 HS-glycoprotein alpha 2 (fetuin); fetuin-A; glycoprotein PP63; phosphorylated N-glycoprotein pp63

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012898.6 → NP_037030.2 alpha-2-HS-glycoprotein precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

P24090, Q5BKD2

UniProtKB/TrEMBL

A6JS49, F1LM19

Related

ENSRNOP00000055223.5, ENSRNOT00000058422.6

Conserved Domains (2) summary

smart00043
Location:26 → 133

CY; Cystatin-like domain

pfam00031
Location:149 → 237

Cystatin; Cystatin domain