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    Spata6 spermatogenesis associated 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171413, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Spata6provided by RGD
    Official Full Name
    spermatogenesis associated 6provided by RGD
    Primary source
    RGD:628657
    See related
    EnsemblRapid:ENSRNOG00000007568 AllianceGenome:RGD:628657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hash
    Summary
    Predicted to enable myosin light chain binding activity. Predicted to be involved in motile cilium assembly and spermatogenesis. Predicted to be located in extracellular region and motile cilium. Predicted to be active in sperm head-tail coupling apparatus. Orthologous to human SPATA6 (spermatogenesis associated 6). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Testes (RPKM 1846.8) and Lung (RPKM 72.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spata6 in Genome Data Viewer
    Location:
    5q35
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (131821585..131905011)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (126593122..126676557)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (131719922..131803853)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ELAV like RNA binding protein 4 Neighboring gene AGBL carboxypeptidase 4 Neighboring gene BEN domain containing 5 Neighboring gene solute carrier family 5 member 9 Neighboring gene selection and upkeep of intraepithelial T cells 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization, expression pattern and chromosomal localization of the spermatogenesis associated 6 gene (Spata6). Oh C, et al. Mol Hum Reprod, 2003 Jun. PMID 12771232
    2. A novel spermatogenesis-related factor-1 gene expressed in maturing rat testis. Yamano Y, et al. Biochem Biophys Res Commun, 2001 Dec 14. PMID 11735130
    3. Spata6 is required for normal assembly of the sperm connecting piece and tight head-tail conjunction. Yuan S, et al. Proc Natl Acad Sci U S A, 2015 Feb 3. PMID 25605924, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables myosin light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin light chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin light chain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in motile cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in motile cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sperm head-tail coupling apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm head-tail coupling apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm head-tail coupling apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm head-tail coupling apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    spermatogenesis-associated protein 6
    Names
    kinesin-related protein HASH
    spermatogenesis-related factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134392.2 → NP_599219.2  spermatogenesis-associated protein 6 precursor

      See identical proteins and their annotated locations for NP_599219.2

      Status: VALIDATED

      Source sequence(s)
      BC158581, JAXUCZ010000005
      UniProtKB/Swiss-Prot
      A0JN12, Q99MU5, Q9EQU0
      UniProtKB/TrEMBL
      A6JZ10
      Related
      ENSRNOP00000010524.5, ENSRNOT00000010524.6
      Conserved Domains (1) summary
      pfam14909
      Location:11 → 149
      SPATA6; Spermatogenesis-assoc protein 6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      131821585..131905011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109229.2 → XP_038965157.1  spermatogenesis-associated protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZST2
      Conserved Domains (1) summary
      pfam14909
      Location:1 → 41
      SPATA6; Spermatogenesis-assoc protein 6

    2. XM_039109230.2 → XP_038965158.1  spermatogenesis-associated protein 6 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MU5.2 GenPept UniProtKB/Swiss-Prot:Q99MU5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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