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    Dpt dermatopontin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289178, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dptprovided by RGD
    Official Full Name
    dermatopontinprovided by RGD
    Primary source
    RGD:1307176
    See related
    EnsemblRapid:ENSRNOG00000002947 AllianceGenome:RGD:1307176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in collagen fibril organization. Predicted to act upstream of or within negative regulation of cell population proliferation. Predicted to be located in extracellular region. Orthologous to human DPT (dermatopontin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 892.0), Heart (RPKM 735.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dpt in Genome Data Viewer
    Location:
    13q23
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (79656341..79684759)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (77123224..77151646)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (83073307..83102404)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096206 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102546371 Neighboring gene uncharacterized LOC134481525 Neighboring gene uncharacterized LOC108352565 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dermatopontin promotes adhesion, spreading and migration of cardiac fibroblasts in vitro. Liu X, et al. Matrix Biol, 2013 Jan. PMID 23262218
    2. Increased expression of dermatopontin mRNA in the infarct zone of experimentally induced myocardial infarction in rats: comparison with decorin and type I collagen mRNAs. Takemoto S, et al. Basic Res Cardiol, 2002 Nov. PMID 12395208
    3. The role of dermatopontin in the stromal organization of the cornea. Cooper LJ, et al. Invest Ophthalmol Vis Sci, 2006 Aug. PMID 16877395, Free PMC Article
    4. Cloning of murine early quiescence-1 gene: the murine counterpart of dermatopontin gene can induce and be induced by cell quiescence. Tzen CY, et al. Exp Cell Res, 2004 Mar 10. PMID 14980498
    5. Targeted disruption of dermatopontin causes abnormal collagen fibrillogenesis. Takeda U, et al. J Invest Dermatol, 2002 Sep. PMID 12230512

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DPT participates in the ventricular remodeling process after MI and may act as a potential therapeutic target for ventricular remodeling.
      Title: Dermatopontin promotes adhesion, spreading and migration of cardiac fibroblasts in vitro.
    2. Coexpression of dermatopontin mRNA with decorin and type I collagen mRNAs suggests that dermatopontin plays role in ECM (fibrillar collagen matrix) reformation in myocardial infarct along with decorin and type I collagen. (dermatopontin)
      Title: Increased expression of dermatopontin mRNA in the infarct zone of experimentally induced myocardial infarction in rats: comparison with decorin and type I collagen mRNAs.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in collagen fibril organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within collagen fibril organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dermatopontin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401366.1 → NP_001388295.1  dermatopontin isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A096MJF1, B2RZ77
      Related
      ENSRNOP00000068106.1, ENSRNOT00000077070.4

    2. NM_001401367.1 → NP_001388296.1  dermatopontin isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6IDF3
      Related
      ENSRNOP00000069812.3, ENSRNOT00000079796.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      79656341..79684759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105965.2: Suppressed sequence

      Description
      NM_001105965.2: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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