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    Ankrd23 ankyrin repeat domain 23 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316330, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ankrd23provided by RGD
    Official Full Name
    ankyrin repeat domain 23provided by RGD
    Primary source
    RGD:1310398
    See related
    EnsemblRapid:ENSRNOG00000016151 AllianceGenome:RGD:1310398
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable titin binding activity and transcription cis-regulatory region binding activity. Involved in response to mechanical stimulus. Located in intercalated disc and myofibril. Biomarker of type 2 diabetes mellitus. Orthologous to human ANKRD23 (ankyrin repeat domain 23). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 4017.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ankrd23 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (46269107..46274578, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (38773234..38778705, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (43110980..43117585, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 4 Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 3 Neighboring gene ankyrin repeat domain 39 Neighboring gene semaphorin 4C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Vascular cell transcriptomic changes to exercise training differ directionally along and between skeletal muscle arteriolar trees. Laughlin MH, et al. Microcirculation, 2017 Feb. PMID 27889934
    2. Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy. Nagueh SF, et al. Circulation, 2004 Jul 13. PMID 15238456
    3. Molecular identification and characterization of a novel nuclear protein whose expression is up-regulated in insulin-resistant animals. Ikeda K, et al. J Biol Chem, 2003 Feb 7. PMID 12456686
    4. Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle. Barash IA, et al. Am J Physiol Cell Physiol, 2007 Jul. PMID 17392382
    5. The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules. Miller MK, et al. J Mol Biol, 2003 Nov 7. PMID 14583192

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables titin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to muscle stretch ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in I band ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercalated disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in myofibril IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108211.2 → NP_001101681.1  ankyrin repeat domain-containing protein 23

      See identical proteins and their annotated locations for NP_001101681.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6B0D0, A0A8I6GH25, A6IND8
      Related
      ENSRNOP00000094368.2, ENSRNOT00000113028.2
      Conserved Domains (3) summary
      sd00045
      Location:179 → 208
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:118 → 165
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:149 → 241
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      46269107..46274578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083570.2 → XP_038939498.1  ankyrin repeat domain-containing protein 23 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GH25, D3ZVB9
      Related
      ENSRNOP00000032505.5, ENSRNOT00000039437.6
      Conserved Domains (3) summary
      sd00045
      Location:171 → 200
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:110 → 157
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:141 → 233
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_039083571.2 → XP_038939499.1  ankyrin repeat domain-containing protein 23 isoform X2

      Conserved Domains (2) summary
      sd00045
      Location:151 → 182
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:126 → 182
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version

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