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    Magoh mago homolog, exon junction complex subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298385, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Magohprovided by RGD
    Official Full Name
    mago homolog, exon junction complex subunitprovided by RGD
    Primary source
    RGD:1305174
    See related
    EnsemblRapid:ENSRNOG00000012778 AllianceGenome:RGD:1305174
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in RNA splicing; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome and exon-exon junction complex. Orthologous to human MAGOH (mago homolog, exon junction complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 269.7), Spleen (RPKM 188.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Magoh in Genome Data Viewer
    Location:
    5q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (127868044..127875423)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (122639268..122646650)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (127480465..127487617)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene LDL receptor related protein 8 Neighboring gene CXXC motif containing zinc binding protein Neighboring gene carnitine palmitoyltransferase 2 Neighboring gene uncharacterized LOC134486962 Neighboring gene zinc finger CCCH-type containing, antiviral 1, pseudogene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RNA splicing capability of live neuronal dendrites. Glanzer J, et al. Proc Natl Acad Sci U S A, 2005 Nov 15. PMID 16275927, Free PMC Article
    2. Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay. Singh KK, et al. RNA Biol, 2013 Aug. PMID 23917022, Free PMC Article
    3. PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs. Diem MD, et al. Nat Struct Mol Biol, 2007 Dec. PMID 18026120
    4. Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators. Michelle L, et al. Mol Cell Biol, 2012 Mar. PMID 22203037, Free PMC Article
    5. Disassembly of exon junction complexes by PYM. Gehring NH, et al. Cell, 2009 May 1. PMID 19410547

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exon-exon junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exon-exon junction complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of exon-exon junction subcomplex mago-y14 IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exon-exon junction subcomplex mago-y14 ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein mago nashi homolog
    Names
    mago homolog, exon junction complex core component
    mago-nashi homolog, proliferation-associated
    mago-nashi-like proliferation-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100536.1 → NP_001094006.1  protein mago nashi homolog

      See identical proteins and their annotated locations for NP_001094006.1

      Status: VALIDATED

      Source sequence(s)
      BQ196337, CK845348, DQ359101
      UniProtKB/Swiss-Prot
      Q27W02
      UniProtKB/TrEMBL
      A6JYS9
      Conserved Domains (1) summary
      cd11295
      Location:4 → 146
      Mago_nashi; Mago nashi proteins, integral members of the exon junction complex

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      127868044..127875423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238510.5 → XP_006238572.1  protein mago nashi homolog isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q8H0
      Related
      ENSRNOP00000017421.5, ENSRNOT00000017422.8
      Conserved Domains (1) summary
      cd11295
      Location:4 → 161
      Mago_nashi; Mago nashi proteins, integral members of the exon junction complex
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27W02.1 GenPept UniProtKB/Swiss-Prot:Q27W02

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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