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    Pgm2 phosphoglucomutase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289632, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Pgm2provided by RGD
    Official Full Name
    phosphoglucomutase 2provided by RGD
    Primary source
    RGD:1306061
    See related
    EnsemblRapid:ENSRNOG00000002185 AllianceGenome:RGD:1306061
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphoglucomutase activity and phosphopentomutase activity. Predicted to act upstream of or within glucose metabolic process. Orthologous to human PGM2 (phosphoglucomutase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 171.3), Spleen (RPKM 104.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pgm2 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (44519906..44553420, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (44166314..44199828, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (45829440..45863883, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 1 Neighboring gene uncharacterized LOC120096609 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene U2 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family. Maliekal P, et al. J Biol Chem, 2007 Nov 2. PMID 17804405
    2. A phylogenetic approach to the identification of phosphoglucomutase genes. Whitehouse DB, et al. Mol Biol Evol, 1998 Apr. PMID 9549096
    3. Evolutionary evidence for a regulator gene controlling the lactate dehydrogenase B gene in rodent erythrocytes. Shows TB, et al. Biochem Genet, 1969 Dec. PMID 5392465
    4. Phosphoglucomutase isozymes of red cells in Mus musculus: additional polymorphism at PGM-l compared by two electrophoretic systems. Miner GD, et al. Biochem Genet, 1972 Dec. PMID 4646763
    5. A null mutation at the mouse Phosphoglucomutase-1 locus and a new locus Pgm-3. Johnson FM, et al. Biochem Genet, 1981 Jun. PMID 6457600

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoglucomutase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphopentomutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphopentomutase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine ribonucleoside salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphopentomutase
    NP_001099477.2
    XP_006251059.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106007.3 → NP_001099477.2  phosphopentomutase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8J8XT82, B1H277, F7FLB2
      Related
      ENSRNOP00000002977.8, ENSRNOT00000002977.7
      Conserved Domains (1) summary
      PTZ00150
      Location:19 → 620
      PTZ00150; phosphoglucomutase-2-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      44519906..44553420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250997.5 → XP_006251059.1  phosphopentomutase isoform X1

      UniProtKB/TrEMBL
      B1H277, F7FLB2
      Conserved Domains (2) summary
      cd05799
      Location:1 → 538
      PGM2; This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and ...
      PTZ00150
      Location:1 → 558
      PTZ00150; phosphoglucomutase-2-like protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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