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    Tbx19 T-box transcription factor 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304935, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tbx19provided by RGD
    Official Full Name
    T-box transcription factor 19provided by RGD
    Primary source
    RGD:1310145
    See related
    EnsemblRapid:ENSRNOG00000002979 AllianceGenome:RGD:1310145
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within several processes, including cell fate commitment; pituitary gland development; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in adrenocorticotropic hormone deficiency; alcohol dependence; and inherited metabolic disorder. Orthologous to human TBX19 (T-box transcription factor 19). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 16.5), Lung (RPKM 8.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbx19 in Genome Data Viewer
    Location:
    13q23
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (79983935..80016219, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (77450848..77484475, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (83403263..83426305, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481586 Neighboring gene uncharacterized LOC120096303 Neighboring gene SFT2 domain containing 2 Neighboring gene TOR signaling pathway regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins. Lamolet B, et al. Cell, 2001 Mar 23. PMID 11290323
    2. Tbx19, a tissue-selective regulator of POMC gene expression. Liu J, et al. Proc Natl Acad Sci U S A, 2001 Jul 17. PMID 11447259, Free PMC Article
    3. Substance dependence low-density whole genome association study in two distinct American populations. Yu Y, et al. Hum Genet, 2008 Jun. PMID 18438686, Free PMC Article
    4. Tpit determines alternate fates during pituitary cell differentiation. Pulichino AM, et al. Genes Dev, 2003 Mar 15. PMID 12651892, Free PMC Article
    5. The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Budry L, et al. Genes Dev, 2012 Oct 15. PMID 23070814, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pituitary gland development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    T-box transcription factor TBX19
    Names
    T-box 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394230.1 → NP_001381159.1  T-box transcription factor TBX19

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6AH75, A0A8I6AWA6
      Related
      ENSRNOP00000062131.2, ENSRNOT00000063870.3
      Conserved Domains (1) summary
      cd20201
      Location:36 → 218
      T-box_TBX19-like; DNA-binding domain of T-box transcription factor 19 and related T-box proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      79983935..80016219 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090785.2 → XP_038946713.1  T-box transcription factor TBX19 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AH75, A0A8I6AWA6
      Conserved Domains (1) summary
      cd20201
      Location:36 → 218
      T-box_TBX19-like; DNA-binding domain of T-box transcription factor 19 and related T-box proteins

    2. XM_039090786.2 → XP_038946714.1  T-box transcription factor TBX19 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AH75, A0A8I6AWA6
      Conserved Domains (1) summary
      cd20201
      Location:36 → 218
      T-box_TBX19-like; DNA-binding domain of T-box transcription factor 19 and related T-box proteins

    3. XM_063272363.1 → XP_063128433.1  T-box transcription factor TBX19 isoform X2

    4. XM_063272362.1 → XP_063128432.1  T-box transcription factor TBX19 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107193.1: Suppressed sequence

      Description
      NM_001107193.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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