Adra2b adrenoceptor alpha 2B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adra2bprovided by RGD
Official Full Name: adrenoceptor alpha 2Bprovided by RGD
Primary source: RGD:2057
See related: EnsemblRapid:ENSRNOG00000013887 AllianceGenome:RGD:2057
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables alpha2-adrenergic receptor activity. Involved in several processes, including female pregnancy; positive regulation of MAPK cascade; and regulation of smooth muscle contraction. Predicted to be located in cell surface; cytosol; and intracellular membrane-bounded organelle. Predicted to be integral component of plasma membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in diabetic neuropathy; hypertension; myocardial infarction; obesity; and type 2 diabetes mellitus. Orthologous to human ADRA2B (adrenoceptor alpha 2B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (135038481..135042527)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (114585174..114589220)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (119805941..119809987)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intraglomerular Monocyte/Macrophage Infiltration and Macrophage-Myofibroblast Transition during Diabetic Nephropathy Is Regulated by the A2B Adenosine Receptor.
Title: Intraglomerular Monocyte/Macrophage Infiltration and Macrophage-Myofibroblast Transition during Diabetic Nephropathy Is Regulated by the A(2B) Adenosine Receptor.
Adra2b signaling is impaired in the cardiomyocytes of spontaneously hypertensive rats starting from 2 months old.
Title: α2-Adrenoceptor signaling in cardiomyocytes of spontaneously hypertensive rats starts to impair already at early age.
Report specific roles of alpha2A - and alpha2B -, but not alpha2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats.
Title: Specific role of α2A - and α2B -, but not α2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats.
In aging, the alpha-2B receptor mediated feedback inhibition of epinephrine release from the adrenal medulla is preserved in control rats but compromised in hypertensive rats, resulting in increased epinephrine release.
Title: Adrenal α2-adrenergic receptors in the aging normotensive and spontaneously hypertensive rat.
Alpha2B-adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface
Title: Alpha2B-adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface.
These data demonstrate that Rab2 and Rab6 differentially influence anterograde transport and signaling of GPCRs.
Title: Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases.
alpha2-adrenoceptors are inhibitory after nerve injury, not excitatory
Title: alpha2-adrenoceptors inhibit the intracellular Ca2+ response to electrical stimulation in normal and injured sensory neurons, with increased inhibition of calcitonin gene-related peptide expressing neurons after injury.
alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation.
Title: alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143739 (e-PCR)
- UniSTS:232985

D3Mco1 (e-PCR)
- UniSTS:239422

D3Mco2 (e-PCR)
- UniSTS:239423

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables alpha2-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha2-adrenergic receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha2-adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables epinephrine binding	IBA Inferred from Biological aspect of Ancestor more info
enables epinephrine binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of uterine smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vascular associated smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alpha-2B adrenergic receptor

Names: Adrenergic alpha2B- receptor class III; Adrenergic, alpha2B-, receptor class III; adrenergic receptor, alpha 2b; adrenergic, alpha-2B-, receptor; alpha-2B adrenoceptor; alpha-2B adrenoreceptor; alpha-2BAR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.