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    Asf1b anti-silencing function 1B histone chaperone [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304648, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Asf1bprovided by RGD
    Official Full Name
    anti-silencing function 1B histone chaperoneprovided by RGD
    Primary source
    RGD:1304918
    See related
    EnsemblRapid:ENSRNOG00000005115 AllianceGenome:RGD:1304918
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable histone binding activity. Predicted to be involved in DNA replication-dependent chromatin assembly and DNA replication-independent chromatin assembly. Predicted to act upstream of or within blastocyst hatching and nucleosome assembly. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human ASF1B (anti-silencing function 1B histone chaperone). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 147.3), Spleen (RPKM 69.9) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Asf1b in Genome Data Viewer
    Location:
    19q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (41085786..41100352, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (24181024..24195604, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (25077918..25092491)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene protein kinase cAMP-activated catalytic subunit alpha Neighboring gene uncharacterized LOC120098559 Neighboring gene small integral membrane protein 46 Neighboring gene uncharacterized LOC120098560 Neighboring gene adhesion G protein-coupled receptor L1 Neighboring gene uncharacterized LOC134483330

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer. Corpet A, et al. EMBO J, 2011 Feb 2. PMID 21179005, Free PMC Article
    2. Transcription initiation factor IID-interactive histone chaperone CIA-II implicated in mammalian spermatogenesis. Umehara T, et al. J Biol Chem, 2003 Sep 12. PMID 12842904
    3. Histone chaperones in nucleosome assembly and human disease. Burgess RJ, et al. Nat Struct Mol Biol, 2013 Jan. PMID 23288364, Free PMC Article
    4. Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Tagami H, et al. Cell, 2004 Jan 9. PMID 14718166
    5. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone chaperone activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication-dependent chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within blastocyst hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone chaperone ASF1B
    Names
    ASF1 anti-silencing function 1 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107160.1 → NP_001100630.1  histone chaperone ASF1B

      See identical proteins and their annotated locations for NP_001100630.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A0A8I5ZUP3, A6IYC4, B0BN69, F7EWU6
      Related
      ENSRNOP00000006964.6, ENSRNOT00000006964.7
      Conserved Domains (1) summary
      pfam04729
      Location:1 → 154
      ASF1_hist_chap; ASF1 like histone chaperone

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      41085786..41100352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097681.2 → XP_038953609.1  histone chaperone ASF1B isoform X1

      Conserved Domains (1) summary
      pfam04729
      Location:1 → 84
      ASF1_hist_chap; ASF1 like histone chaperone
    Nucleotide Protein Strain
    Heading Accession and Version

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