Arl8b ARF like GTPase 8B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arl8bprovided by RGD
Official Full Name: ARF like GTPase 8Bprovided by RGD
Primary source: RGD:1562830
See related: EnsemblRapid:ENSRNOG00000055860 AllianceGenome:RGD:1562830
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable G protein activity; guanyl ribonucleotide binding activity; and tubulin binding activity. Predicted to be involved in several processes, including antigen processing and presentation following phagocytosis; cytosolic transport; and vesicle fusion. Predicted to act upstream of or within endosomal transport. Predicted to be located in several cellular components, including cytolytic granule membrane; midbody; and spindle midzone. Predicted to be active in early endosome membrane and lysosomal membrane. Orthologous to human ARL8B (ADP ribosylation factor like GTPase 8B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 407.2), Heart (RPKM 360.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q41

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (143304597..143348580)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (141748634..141792605)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (140837745..140881866)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein activity	ISO Inferred from Sequence Orthology more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterograde axonal transport	ISO Inferred from Sequence Orthology more info
involved_in antigen processing and presentation following phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in antigen processing and presentation following phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in antigen processing and presentation of polysaccharide antigen via MHC class II	ISO Inferred from Sequence Orthology more info
involved_in antigen processing and presentation of polysaccharide antigen via MHC class II	ISS Inferred from Sequence or Structural Similarity more info
involved_in autophagosome-lysosome fusion	ISO Inferred from Sequence Orthology more info
involved_in autophagosome-lysosome fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion regulated lysosome exocytosis	ISO Inferred from Sequence Orthology more info
involved_in calcium ion regulated lysosome exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in early endosome to Golgi transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endosomal transport	ISO Inferred from Sequence Orthology more info
involved_in endosome to lysosome transport of low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
involved_in endosome to lysosome transport of low-density lipoprotein particle	ISS Inferred from Sequence or Structural Similarity more info
involved_in late endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in late endosome to lysosome transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
involved_in phagosome-lysosome fusion	ISO Inferred from Sequence Orthology more info
involved_in phagosome-lysosome fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasma membrane repair	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to early endosome	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in viral exocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytolytic granule membrane	IEA Inferred from Electronic Annotation more info
located_in cytolytic granule membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in spindle midzone	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP-ribosylation factor-like protein 8B

Names: ADP-ribosylation factor like GTPase 8B; ADP-ribosylation factor-like 8B

NP_001019503.1

EC 3.6.5.2

XP_038964126.1

EC 3.6.5.2

XP_038964127.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024332.1 → NP_001019503.1 ADP-ribosylation factor-like protein 8B

See identical proteins and their annotated locations for NP_001019503.1

Status: PROVISIONAL

Source sequence(s)

BC081947

UniProtKB/Swiss-Prot

Q66HA6

UniProtKB/TrEMBL

A0A8I5ZTT2, A6IBL4

Related

ENSRNOP00000071470.3, ENSRNOT00000080663.3

Conserved Domains (1) summary

cd04159
Location:22 → 180

Arl10_like; Arf-like 9 (Arl9) and 10 (Arl10) GTPases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

143304597..143348580

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108198.2 → XP_038964126.1 ADP-ribosylation factor-like protein 8B isoform X1

Conserved Domains (1) summary

cd04159
Location:22 → 125

Arl10_like; Arf-like 9 (Arl9) and 10 (Arl10) GTPases
XM_039108199.2 → XP_038964127.1 ADP-ribosylation factor-like protein 8B isoform X2

Conserved Domains (1) summary

cd04159
Location:1 → 132

Arl10_like; Arf-like 9 (Arl9) and 10 (Arl10) GTPases