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    Nusap1 nucleolar and spindle associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311336, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Nusap1provided by RGD
    Official Full Name
    nucleolar and spindle associated protein 1provided by RGD
    Primary source
    RGD:1305764
    See related
    EnsemblRapid:ENSRNOG00000004921 AllianceGenome:RGD:1305764
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in establishment of mitotic spindle localization; mitotic chromosome condensation; and mitotic cytokinesis. Predicted to act upstream of or within mitotic sister chromatid segregation and positive regulation of mitotic nuclear division. Predicted to be located in cytoplasm and microtubule. Predicted to be active in mitotic spindle and nucleolus. Orthologous to human NUSAP1 (nucleolar and spindle associated protein 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Thymus (RPKM 251.2), Spleen (RPKM 117.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nusap1 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (127057220..127092779)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (106603273..106633428)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (111422267..111452600)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene OIP5 antisense RNA 1 Neighboring gene Opa interacting protein 5 Neighboring gene 40S ribosomal protein S20 pseudogene Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 1 Neighboring gene Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) Neighboring gene inositol-trisphosphate 3-kinase A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization. Raemaekers T, et al. J Cell Biol, 2003 Sep 15. PMID 12963707, Free PMC Article
    2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of mitotic spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within establishment of mitotic spindle localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitotic sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar and spindle-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107762.2 → NP_001101232.1  nucleolar and spindle-associated protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001101232.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HPG6, A6HPG7, D4AAK2
      Related
      ENSRNOP00000106878.1, ENSRNOT00000158938.1
      Conserved Domains (1) summary
      pfam16006
      Location:160 → 370
      NUSAP; Nucleolar and spindle-associated protein

    2. NM_001399531.1 → NP_001386460.1  nucleolar and spindle-associated protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      B1WBZ5
      Related
      ENSRNOP00000070384.2, ENSRNOT00000081934.3
      Conserved Domains (1) summary
      pfam16006
      Location:160 → 410
      NUSAP; Nucleolar and spindle-associated protein

    3. NM_001399533.1 → NP_001386462.1  nucleolar and spindle-associated protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      Related
      ENSRNOP00000045376.4, ENSRNOT00000052312.6
      Conserved Domains (1) summary
      pfam16006
      Location:160 → 409
      NUSAP; Nucleolar and spindle-associated protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      127057220..127092779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762101.3 → XP_008760323.1  nucleolar and spindle-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JXS3
      Conserved Domains (1) summary
      pfam16006
      Location:154 → 380
      NUSAP; Nucleolar and spindle-associated protein

    2. XM_008762102.3 → XP_008760324.1  nucleolar and spindle-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JXS3, A0A8I6AB59
      Related
      ENSRNOP00000089210.1, ENSRNOT00000105321.2
      Conserved Domains (1) summary
      pfam16006
      Location:154 → 379
      NUSAP; Nucleolar and spindle-associated protein

    3. XM_006234770.4 → XP_006234832.1  nucleolar and spindle-associated protein 1 isoform X3

      UniProtKB/TrEMBL
      A6HPG7
      Conserved Domains (1) summary
      pfam16006
      Location:111 → 361
      NUSAP; Nucleolar and spindle-associated protein

    4. XM_063283712.1 → XP_063139782.1  nucleolar and spindle-associated protein 1 isoform X4

    5. XM_063283713.1 → XP_063139783.1  nucleolar and spindle-associated protein 1 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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