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    Med13 mediator complex subunit 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303403, updated on 28-Oct-2024

    Summary

    Official Symbol
    Med13provided by RGD
    Official Full Name
    mediator complex subunit 13provided by RGD
    Primary source
    RGD:1304829
    See related
    EnsemblRapid:ENSRNOG00000003679 AllianceGenome:RGD:1304829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Thrap1
    Summary
    Predicted to enable nuclear thyroid hormone receptor binding activity and transcription coactivator activity. Predicted to be involved in cholesterol homeostasis; regulation of DNA-templated transcription; and triglyceride homeostasis. Predicted to be located in nucleoplasm. Predicted to be part of CKM complex and mediator complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human MED13 (mediator complex subunit 13). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Thymus (RPKM 434.7), Kidney (RPKM 265.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Med13 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (71584354..71674614, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (71086978..71176535, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (73702327..73787084, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene transfer RNA valine (anticodon AAC) 22 Neighboring gene BRCA1 interacting helicase 1 Neighboring gene integrator complex subunit 2 Neighboring gene uncharacterized LOC120095332 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of CKM complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of mediator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 13
    Names
    thyroid hormone receptor associated protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415085.1NP_001402014.1  mediator of RNA polymerase II transcription subunit 13

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      F1LXU0
      Related
      ENSRNOP00000032864.6, ENSRNOT00000035280.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      71584354..71674614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086047.2XP_038941975.1  mediator of RNA polymerase II transcription subunit 13 isoform X1

      UniProtKB/TrEMBL
      A0A8I5YBV3, A6HHQ5
      Conserved Domains (2) summary
      pfam06333
      Location:16262029
      Med13_C; Mediator complex subunit 13 C-terminal
      pfam18296
      Location:12351590
      MID_MedPIWI; MID domain of medPIWI

    RNA

    1. XR_005489839.2 RNA Sequence

    2. XR_005489840.2 RNA Sequence